A5049878377- Chemical Synthesis and Analysis
- Neuropeptides and Animal Physiology
- Pharmacological Receptor Mechanisms and Effects
- Click Chemistry and Applications
- Receptor Mechanisms and Signaling
- Carbohydrate Chemistry and Synthesis
- Fluorine in Organic Chemistry
- Peptidase Inhibition and Analysis
- Asymmetric Synthesis and Catalysis
- Microbial Natural Products and Biosynthesis
- Synthetic Organic Chemistry Methods
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Synthesis and Reactivity of Heterocycles
- Synthesis and Reactions of Organic Compounds
- Computational Drug Discovery Methods
- Synthesis and Biological Evaluation
- Chemical synthesis and alkaloids
- Cannabis and Cannabinoid Research
- Synthesis and Catalytic Reactions
- X-ray Diffraction in Crystallography
- Monoclonal and Polyclonal Antibodies Research
- Crystallization and Solubility Studies
- Steroid Chemistry and Biochemistry
- Chemical Synthesis and Reactions
- Synthesis of β-Lactam Compounds
Washington University in St. Louis
2020-2025
Cubist Pharmaceuticals (United States)
2006-2016
RTI International
2014
Triangle
2014
École Supérieure de Biotechnologie de Strasbourg
2012
Université de Strasbourg
2012
Inserm
2012
Ligand Pharmaceuticals (United States)
2009-2010
National Institutes of Health
2008-2010
National Human Genome Research Institute
2008-2010
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPractical synthesis of oligosaccharides. Partial avermectin B1aK. C. Nicolaou, R. E. Dolle, and D. P. PapahatjisCite this: J. Am. Chem. Soc. 1984, 106, 15, 4189–4192Publication Date (Print):July 1, 1984Publication History Published online1 May 2002Published inissue 1 July 1984https://pubs.acs.org/doi/10.1021/ja00327a021https://doi.org/10.1021/ja00327a021research-articleACS PublicationsRequest reuse permissionsArticle...
Inflammasomes induce maturation of the inflammatory cytokines IL-1β and IL-18, whose activity is associated with pathophysiology a wide range infectious diseases. As validated therapeutic targets for treatment acute chronic diseases, there has been intense interest in developing small-molecule inhibitors to target inflammasome reduce disease-associated burden.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTP1 Aspartate-Based Peptide .alpha.-((2,6-Dichlorobenzoyl)oxy)methyl Ketones as Potent Time-Dependent Inhibitors of Interleukin-1.beta.-Converting EnzymeRoland E. Dolle, Denton Hoyer, C. V. Prasad, Stanley J. Schmidt, Carla T. Helaszek, Robert Miller, and Mark A. AtorCite this: Med. Chem. 1994, 37, 5, 563–564Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March...
K. C. Nicolaou, A. Chucholowski, R. E. Dolle and J. L. Randall, Chem. Soc., Commun., 1984, 1155 DOI: 10.1039/C39840001155
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of elfamycins: aurodox and efrotomycin. 1. Strategy construction key intermediatesR. E. Dolle K. C. NicolaouCite this: J. Am. Chem. Soc. 1985, 107, 6, 1691–1694Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://doi.org/10.1021/ja00292a038Request reuse permissionsArticle Views1259Altmetric-Citations132LEARN ABOUT THESE METRICSArticle Views are the...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of ionophore antibiotic X-14547AK. C. Nicolaou, D. P. Papahatjis, A. Claremon, R. L. Magolda, and E. DolleCite this: J. Org. Chem. 1985, 50, 9, 1440–1456Publication Date (Print):May 1, 1985Publication History Published online1 May 2002Published inissue 1 1985https://pubs.acs.org/doi/10.1021/jo00209a017https://doi.org/10.1021/jo00209a017research-articleACS PublicationsRequest reuse permissionsArticle...
10-Hydroxy-10,9-boroxarophenanthrenes were obtained as unexpected major products upon BBr(3)-mediated O-demethylation of 2-methoxybiaryls. The formation likely proceeds via intramolecular electrophilic aromatic cyclization a reactive dibromoaryloxyborane intermediate. Essentially quantitative yields 10-hydroxy-10,9-boroxarophenanthrenes also from 2-hydroxybiaryl and BCl(3)/AlCl(3) with use modified literature procedure. As synthetic intermediates, efficiently converted to 3,4-benzocoumarins...
ADVERTISEMENT RETURN TO ISSUEReviewNEXTComprehensive Survey of Combinatorial Library Synthesis: 2004Roland E. DolleView Author Information Department Chemistry, Adolor Corporation, 700 Pennsylvania Drive, Exton, 19341 Cite this: J. Comb. Chem. 2005, 7, 6, 739–798Publication Date (Web):September 17, 2005Publication History Received29 June 2005Published online17 September inissue 1 November 2005https://pubs.acs.org/doi/10.1021/cc050082thttps://doi.org/10.1021/cc050082treview-articleACS...
R. E. Dolle, S. J. Schmidt and L. I. Kruse, Chem. Soc., Commun., 1987, 904 DOI: 10.1039/C39870000904
ADVERTISEMENT RETURN TO ISSUEPREVArticleDesign of potent non-peptide competitive antagonists the human bradykinin B2 receptorJoseph M. Salvino, Peter R. Seoane, Brent D. Douty, Mohamad A. Awad, Roland E. Dolle, Wayne T. Houck, David Faunce, and G. SawutzCite this: J. Med. Chem. 1993, 36, 17, 2583–2584Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://doi.org/10.1021/jm00069a021RIGHTS & PERMISSIONSArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA general and stereocontrolled total synthesis of leukotriene B4 analogsK. C. Nicolaou, R. E. Zipkin, Dolle, B. D. HarrisCite this: J. Am. Chem. Soc. 1984, 106, 12, 3548–3551Publication Date (Print):June 1, 1984Publication History Published online1 May 2002Published inissue 1 June 1984https://pubs.acs.org/doi/10.1021/ja00324a024https://doi.org/10.1021/ja00324a024research-articleACS PublicationsRequest reuse permissionsArticle...
Selective δ opioid receptor agonists are promising potential therapeutic agents for the treatment of various types pain conditions. A spirocyclic derivative was identified as a hit through screening. Subsequent lead optimization compound 20 (ADL5859) potent, selective, and orally bioavailable agonist. Compound selected clinical candidate pain.
K. C. Nicolaou, R. E. Dolle, A. Chucholowski and J. L. Randall, Chem. Soc., Commun., 1984, 1153 DOI: 10.1039/C39840001153
Selective, nonpeptidic δ opioid receptor agonists have been the subject of great interest as potential novel analgesic agents. The discoveries BW373U86 (1) and SNC80 (2) contributed to rapid expansion research in this field. However, poor drug-like properties low therapeutic indices prevented clinical evaluation these Doses 1 2 similar those required for activity produce convulsions rodents nonhuman primates. Recently, we described a series potent, selective, orally bioavailable delta...