A5046183852- Monoclonal and Polyclonal Antibodies Research
- Radiopharmaceutical Chemistry and Applications
- Immunotherapy and Immune Responses
- Malaria Research and Control
- CAR-T cell therapy research
- Impact of Technology on Adolescents
- Immune Cell Function and Interaction
- Bone health and treatments
- T-cell and B-cell Immunology
- Bone Metabolism and Diseases
- Stress Responses and Cortisol
- Social Media and Politics
- Memory and Neural Mechanisms
- Biomedical Text Mining and Ontologies
- Electronic Health Records Systems
- Prostate Cancer Treatment and Research
- Computational Drug Discovery Methods
- Education and Military Integration
- Mass Spectrometry Techniques and Applications
- Digital Communication and Language
- Customer Service Quality and Loyalty
- Cancer Immunotherapy and Biomarkers
- Technology Adoption and User Behaviour
- Organic Chemistry Cycloaddition Reactions
- Chemical Synthesis and Analysis
Australasian College of Dermatologists
2020-2024
Aptevo Therapeutics (United states)
2017-2023
Central Michigan University
2009-2023
University College Hospital
1987-2021
University College London
1987-2021
University of Birmingham
2020
College of San Mateo
2020
New York Proton Center
2017-2018
University of Pittsburgh
1971-2018
Case Western Reserve University
2018
Although recent studies suggest that interferons can increase the number of IgG Fc receptor (FcR gamma) sites on mouse macrophages, direct assessment similar effects human mononuclear phagocytes is lacking. We therefore measured specific binding 125I- and fluorescein-labeled IgG1 to monocytes leukemic cell lines after culture in vitro with highly purified interferons. report natural recombinant gamma-interferon causes a dramatic (nearly 10-fold) FcR gamma normal HL-60 U-937. Alpha...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIn Vitro Antimalarial Activity of Chalcones and Their DerivativesRongshi Li, George L. Kenyon, Fred E. Cohen, Xiaowu Chen, Baoqing Gong, Jose N. Dominguez, Eugene Davidson, Gary Kurzban, Robert Miller, Edwin O. Nuzum, Philip J. Rosenthal, James H. McKerrowCite this: Med. Chem. 1995, 38, 26, 5031–5037Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December...
Senders viewed 25 emotionally loaded color slides. Their facial expressions were observed via a hidden television camera by observers who made judgments about the nature of each slide and sender's reaction to it. A total 64 undergraduates arranged in eight pairings females sending male observers, females, males males, females. Statistically significant communication was demonstrated, with being more accurate senders than males. More tended show smaller skin conductance heart rale response...
Journal Article Differential ability of Th1 and Th2 T cells to express Fas ligand undergo activation-induced cell death Get access Fred Ramsdell, Ramsdell Department Immunobiology, Immunex Research Development CorporationSeattle, WA, USA Correspondence to: F. Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael S. Seaman, Seaman Robert E. Miller, Miller Kathleen Picha, Picha Mary K. Kennedy, Kennedy David H. Lynch International Immunology, Volume 6, Issue...
SUMMARYAn understanding of sexuality and life cycle has been conspicuously lacking for members the genus Agaricus despite prime importance bisporus to edible mushroom industry. Recent work on fertility patterns among monosporous isolates rare 4-spored basidia suggests secondary homothallism a bipolar pattern as characteristic this species. A full elucidation its relation cycle, however, depends upon use genetic techniques. Nutritionally deficient mutations have accordingly obtained in...
Abstract BACKGROUND Metastases to bone are a frequent complication of human prostate cancer and result in the development osteoblastic lesions that include an underlying osteoclastic component. Previous studies rodent models breast have established receptor activator NF‐κB ligand (RANKL) inhibition decreases lesion tumor growth bone. RANK is essential for osteoclast differentiation, activation, survival via its expression on osteoclasts their precursors. has also been observed some cell...
Abstract Mice genetically deficient in IL-7R(alpha) are highly lymphopenic the peripheral lymphoid organs. The functional competence of T cells that have developed absence an IL-7R signal was investigated. Three important observations were made using several vitro activation regimens. First, stimulation from -/- mice at limiting dilution with immobilized Abs to CD3, CD4 or CD8, and CD18 revealed a six- sevenfold reduction frequency clonogenic compared +/+ mice. also significantly less...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTP1 Aspartate-Based Peptide .alpha.-((2,6-Dichlorobenzoyl)oxy)methyl Ketones as Potent Time-Dependent Inhibitors of Interleukin-1.beta.-Converting EnzymeRoland E. Dolle, Denton Hoyer, C. V. Prasad, Stanley J. Schmidt, Carla T. Helaszek, Robert Miller, and Mark A. AtorCite this: Med. Chem. 1994, 37, 5, 563–564Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March...
Abstract Mice homozygous for either the lpr or gld genes develop phenotypically identical autoimmune disorders. The gene responsible pathology in lpr/lpr mice encodes Fas antigen, a protein associated with induction of programmed cell death. To determine if defect represents mutation ligand Fas, we have assessed ability lymphoid cells from gld/gld to lyse target Fas‐dependent manner. Using an antagonistic antibody demonstrate that activated T normal and are capable inducing Fas‐mediated...
4-1BB (CD137) is a member of the TNFR superfamily (TNFRSF9). T cell expression restricted to activated cells, and cross-linking has been shown deliver costimulatory signal. Here we have that treatment tumor-bearing mice with agonistic 4-1BB-specific Abs can lead cell-mediated tumor rejection. In vivo mAb depletion experiments demonstrated this rejection requires CD8(+) cells but not CD4(+) or NK cells. Both IFN-gamma- CD40-mediated signals were also required, because no benefit was observed...
Tests made of the sensory-perceptual, cognitive, and psychomotor abilities untreated young patients with essential hypertension have revealed a pattern suggesting slight functional impairment central nervous system. Reduced performance was most marked for those tasks requiring speed coordination, particularly when behaviors observed were self-initiated. Lowered scores more evident among female hypertensives; no differences in by race noted. The deficits measured these sensitive tests do not...
Antimicrobial stewardship programs aim to reduce inappropriate hospital antimicrobial use. At the Johns Hopkins Children's Medical and Surgical Center (Baltimore, MD), we implemented a World Wide Web-based restriction program address problems with existing program.A user survey identified opportunities for improvement of an resulted in subsequent design, implementation, evaluation at 175-bed, tertiary care pediatric teaching hospital. The provided automated clinical decision support,...
Treatment of metastatic, castration-resistant prostate cancer (mCRPC) remains a highly unmet medical need and current therapies ultimately result in disease progression. Immunotherapy is rapidly growing approach for treatment but has shown limited success to date the mCRPC. We have developed novel humanized bispecific antibody, MOR209/ES414, built on ADAPTIR (modular protein technology) platform, redirect T-cell cytotoxicity toward cells by specifically targeting T through CD3ε expressing...