A5073528933- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Glutathione Transferases and Polymorphisms
- Cancer-related Molecular Pathways
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Pharmacological Effects and Toxicity Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Peroxisome Proliferator-Activated Receptors
- Heavy Metal Exposure and Toxicity
- Renal and related cancers
- Heavy metals in environment
- Drug Transport and Resistance Mechanisms
- Endometriosis Research and Treatment
- Vitamin D Research Studies
- Cancer Research and Treatments
- HIV-related health complications and treatments
- Renin-Angiotensin System Studies
- Cholesterol and Lipid Metabolism
- Hormonal Regulation and Hypertension
Dhaka Medical College and Hospital
2020-2022
University of Dhaka
2014-2021
To investigate the association between three most common single nucleotide polymorphisms of N-acetyltransferase 2 gene together with cigarette smoking and risk developing bladder cancer its aggressiveness.A case-control study on 102 patients 140 control subjects was conducted. The genomic DNA extracted from peripheral white blood cells alleles were differentiated by polymerase chain reaction-based restriction fragment length polymorphism methods.Bladder estimated as odds ratio 95% confidence...
TP53 is considered to be the most frequently mutated gene in every forms of human cancer. The objective this study was evaluate association codon 72 and 248 polymorphisms with susceptibility severity bladder cancer Bangladeshi population. A case-control on 102 patients 140 control subjects conducted. genotype analysis done by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) method. Pro/Pro genotypes at position were high risk (odds ratio (OR) = 3.02; 95 %...
Background: Hepatocellular carcinoma (HCC) is one of the fatal cancer types worldwide, and a variety genetic factors are considered to be associated with this incidence. MDM2 gene plays pivotal role in various pathways, which essential combat tumor formation. The study aimed find out associations (T309G, rs2279744) polymorphism development HCC Bangladeshi population. Methods: A case-control on 100 patients 110 control subjects was conducted. genotyping (T309G) done using PCR-RFLP methods....
3C-like protease also called the main is an essential enzyme for completion of life cycle Middle East Respiratory Syndrome Coronavirus. In our study we predicted compounds which are capable inhibiting protease, and thus inhibit lifecycle Coronavirus using in silico methods.Lead like drug molecules was identified by structure-based virtual screening ligand-based method. Further, were validated through absorption, distribution, metabolism excretion filtering.Based on binding energy, ADME...
Abstract Rationale The global public health is in serious crisis due to emergence of SARS-CoV-2 virus. Studies are ongoing reveal the genomic variants virus circulating various parts world. However, data generated from low- and middle-income countries scarce resource limitation. This study was focused perform whole genome sequencing 151 isolates COVID-19 positive Bangladeshi patients. goal this identify among Bangladesh, determine molecular epidemiology develop a relationship between host...
Worldwide, pre‐eclampsia (PE) ranks as a major obstetric problem leading to substantial maternal and perinatal morbidity mortality, especially in developing countries. Clinically it appears syndrome, including hypertension proteinuria after second half of pregnancy. PE affected by genetic trait, is associated with oxidative stress due imbalance between the production reactive oxygen species ability antioxidant process. The glutathione S‐transferases (GST) are group enzymes which involved...
The study aimed to assess the association of ACE insertion/deletion (I/D) polymorphisms with susceptibility for preeclampsia in Bangladesh. It was a case-control involving 220 subjects (100 preeclamptic and 120 normal pregnant women). genotyping done using conventional PCR method. Overall, frequency II genotypes significantly (p<.05) higher women than women. mother DD genotype at 3.43-fold risk (OR = 3.43; p<.01) developing while ID lower 1.32; p>.05). On other hand, patients having either...
Background: Contamination of soil and agricultural products by heavy metals resulting from rapid industrial development has caused major concern. Dietary exposure to been associated with toxic adverse health effects. The main threats human are Pb, Cd Hg. aim this study was monitor the presence metals, minerals trace elements in cereals consumed Dhaka city residents. Methods: One hundred sixty cereal samples were collected for eight (08) composited analyzed determination sixteen elements....
The goal of this study was to identify the genomic variants and determine molecular epidemiology SARS-CoV-2 virus during early pandemic stage in Bangladesh. Viral RNA extracted, converted cDNA, amplified using Ion AmpliSeq™ Research Panel. 413 unique mutants from 151 viral isolates were identified. 80% cases belongs 8 mutants: 241C toT, 1163A 3037C 14408C 23403A toG, 28881G toA, 28,882 G 28883G toC. Observed dominance GR clade that have strong presence Europe, suggesting European channel a...
This study determined five coding-complete genome sequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains isolated from oropharyngeal swab specimens Bangladeshi patients who were diagnosed with disease 2019 (COVID-19) and had no travel history.
Similar to other studies around the world, goal of this study was identify genomic variants and determine molecular epidemiology SARS-CoV-2 virus during early pandemic stage in Bangladesh. Viral RNA extracted, converted cDNA, amplified using Ion AmpliSeq TM Research Panel. 413 unique from 151 viral isolates were identified. 80 % cases belongs 8 variants: 241C toT, 1163A 3037C 14408C 23403A toG, 28881G toA, 28882 G 28883G toC. Observed dominance GR clade that have strong presence Europe,...