A5069566791- Herpesvirus Infections and Treatments
- Toxin Mechanisms and Immunotoxins
- Research on Leishmaniasis Studies
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cytomegalovirus and herpesvirus research
Institute of Virology of the Slovak Academy of Sciences
2021
Abstract Herpes simplex virus 1 (HSV-1) infection and stress responses disrupt transcription termination by RNA Polymerase II (Pol II). In HSV-1 but not upon salt or heat stress, this is accompanied a dramatic increase in chromatin accessibility downstream of genes. Here, we show that the immediate-early protein ICP22 both necessary sufficient to induce open regions (dOCRs) disrupted termination. This was matched marked ICP22-dependent loss histones affected genes consistent with impaired...
Abstract Herpesviruses have mastered host cell modulation and immune evasion to augment productive infection, life-long latency reactivation thereof 1,2. A long appreciated, yet elusively defined relationship exists between the lytic-latent switch viral non-coding RNAs 3,4. Here, we identify miRNA-mediated inhibition of miRNA processing as a novel cellular mechanism that human herpesvirus 6A (HHV-6A) exploits disrupt mitochondrial architecture, evade intrinsic defense drive latent-lytic...