A5015351640- Acute Ischemic Stroke Management
- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Atrial Fibrillation Management and Outcomes
- Melanoma and MAPK Pathways
- Venous Thromboembolism Diagnosis and Management
- Renal Diseases and Glomerulopathies
- Geological and Geochemical Analysis
- Cerebrovascular and Carotid Artery Diseases
- Pancreatic and Hepatic Oncology Research
- Renal cell carcinoma treatment
- Cardiac tumors and thrombi
- PI3K/AKT/mTOR signaling in cancer
- Geochemistry and Geologic Mapping
- CAR-T cell therapy research
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Blood disorders and treatments
- Fibroblast Growth Factor Research
- Renal and related cancers
- Intracerebral and Subarachnoid Hemorrhage Research
- Chemical Synthesis and Analysis
- Peripheral Artery Disease Management
- Geological and Tectonic Studies in Latin America
- Monoclonal and Polyclonal Antibodies Research
Lehigh Valley Hospital-Pocono
2020-2024
Lehigh Valley Health Network
2020-2024
Health Net
2022
SUNY Upstate Medical University
2017-2018
Guthrie Robert Packer Hospital
2017-2018
MacNeal Hospital
2018
Commonwealth Medical College
2017
In recent years, the role of immune checkpoint inhibitors (ICI) in cancer treatment has rapidly expanded. randomized clinical trials, these agents have demonstrated efficacy extending survival and increasing response rates. Immune-related adverse effects (irAEs) involving various organs been frequently narrated. Herein, we present a case report thrombotic thrombocytopenic purpura (TTP) as rare side effect nivolumab, plus ipilimumab, metastatic renal cell carcinoma (RCC). A review literature...
Melanoma is characterized by oncogenic mutations in pathways regulating cell growth, proliferation, and metabolism. Greater than 80% of primary melanoma cases harbor aberrant activation the mitogen-activated protein kinase kinase/extracellular-signal-regulated (MEK/ERK) pathway, with BRAF, most notably BRAF V600E, being common. Significant progress has been made BRAF-mutant using MEK inhibitors; however, non-V600 remain a challenge limited treatment options. We report case an individual...
Acquired von Willebrand syndrome (AVWS) is an increasingly recognized entity with numerous potential underlying etiologies. Most commonly implicated are lymphoproliferative, myeloproliferative, cardiovascular, and autoimmune disorders. Unlike inherited disease (vWD), AVWS tends to present at older age without a family history of vWD. Treatment directed the etiology if one uncovered, as well treatment prevention bleeding. Here, we rare case secondary Waldenström macroglobulinemia which went...
Background Thrombophilia workup is typically inappropriate in the inpatient setting as testing may be skewed by anticoagulation, acute thrombosis, or illness. Objective To determine adherence of thrombophilia with institutional guidelines. Patients and methods A retrospective study to evaluate practices adult patients who were admitted Lehigh Valley Hospital at Cedar Crest either venous thromboembolism ischemic stroke 2019. Testing included inherited acquired thrombophilia. Patient charts...
We present a case of left upper extremity paresis secondary to acute brachial artery occlusion in an elderly female with active non-ST segment elevation myocardial ischemia (NSTEMI) the setting paroxysmal atrial fibrillation. The patient was initially suspected have cerebrovascular attack (CVA); however, computed tomography (CT) head negative for stroke. diagnosis confirmed by tomographic angiography (CTA) extremity, confirming occlusion. In evaluating concern stroke atypical presentation,...
The treatment of metastatic renal cell carcinoma (RCC) has been radically changed by the advent tyrosine kinase inhibitors (TKIs). However, few reports have described their role in cardiac metastases. We present a case left ventricular metastasis from RCC that was managed with pazopanib therapy.A 74-year-old male stage I underwent right nephrectomy 2004 and lung resection 2009. He well till March 2016, when he presented chest pain. Cardiac catheterization revealed highly vascular mass apex....
Background: Acute chest syndrome (ACS), a well-known medical emergency in sickle cell disease (SCD) presents as pain and dyspnea.SCD patients with pulmonary embolism (PE) present similarly, but PE is not the first diagnosis that physicians consider this patient population.PE occurs approximately 17% of SCD patients, while there an increased risk trait.Standard tools approaching PE, such Wells score, are limited use due to absence other venous thromboembolism (VTE) factors.This results low...
Metastatic melanoma refractory to checkpoint inhibitors is a challenging clinical scenario. We present the case of patient who was standard care but able achieve durable complete remission with combination stereotactic body radiation therapy (SBRT), talimogene laherparepvec (TVEC), and ipilimumab.