A5058449981- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Cancer, Lipids, and Metabolism
- Renal and related cancers
- Radiomics and Machine Learning in Medical Imaging
- Ubiquitin and proteasome pathways
- Advanced X-ray and CT Imaging
- Immune cells in cancer
- Glutathione Transferases and Polymorphisms
- Urinary and Genital Oncology Studies
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Phagocytosis and Immune Regulation
- Cancer-related Molecular Pathways
- Renal Diseases and Glomerulopathies
- Genomics and Chromatin Dynamics
- Histone Deacetylase Inhibitors Research
- Microtubule and mitosis dynamics
Shanghai Jiao Tong University
2021-2024
Shanghai First People's Hospital
2021-2024
Lactic acid was previously considered a waste product of glycolysis, and has now become key metabolite for cancer development, maintenance metastasis. So far, numerous studies have confirmed that tumor lactic levels are associated with increased metastasis, recurrence poor prognosis. However, the prognostic value metabolism transporter related genes in patients clear cell renal carcinoma not been explored. We selected twenty-one LASSO cox regression analysis E-MTAB-1980 cohort, finally...
Abstract Exploring useful prognostic markers and developing a robust model for patients with prostate cancer are crucial clinical practice. We applied deep learning algorithm to construct proposed the learning-based ferroptosis score (DLFscore) prediction of prognosis potential chemotherapy sensitivity in cancer. Based on this model, there was statistically significant difference disease-free survival probability between high low DLFscore The Cancer Genome Atlas (TCGA) cohort (P <...
Abstract Due to the complicated histopathological characteristics of clear-cell renal-cell carcinoma (ccRCC), non-invasive prognosis before operative treatment is crucial in selecting appropriate treatment. A total 126 345 computerized tomography (CT) images from four independent patient cohorts were included for analysis this study. We propose a V Bottleneck multi-resolution and focus-organ network (VB-MrFo-Net) using cascade framework deep learning analysis. The VB-MrFo-Net achieved better...
Advanced renal cell carcinoma (RCC) poses a threat to patient survival. Epigenetic remodelling is the pathogenesis of cancer. Histone demethylase 4B (KDM4B) overexpressed in many cancers through various pathways. However, role KDM4B clear has not yet been elucidated. The differential expression was first verified by analysing public databases. fresh tissues and pathology slides further analysed western blotting immunohistochemical staining. overexpression knockdown lines were also...
Abstract Background Currently, there is no research available on the prognosis, potential effect and therapeutic value of USP31 in clear cell renal carcinoma (ccRCC). To address this gap, present study aimed to shed light its roles possible mechanisms ccRCC. Methods R software was utilized conduct bioinformatics analyses with data derived from The Cancer Genome Atlas (i.e. KIRC) Gene Expression Omnibus datasets. expression ccRCC validated by a PCR. independent prognostic ability evaluated...
Recent studies have reported that MLST8 is upregulated in many malignant tumors. Nevertheless, the underlying molecular mechanism still unclear. The aim of this work was to investigate how contributes development and progression clear cell renal carcinoma (ccRCC). an oncogenic protein TCGA database ccRCC clinical specimens. We also ascertain interacts with FBXW7, which universally regarded as E3 ubiquitin ligase. can be degraded ubiquitinated by tumor suppressor FBXW7. FBXW7 recognizes a...
Immunotherapy is considered to be one of the most promising curative modalities for cancer, and effectiveness immunotherapy depends on abundance immune cells in tumor microenvironment (TME). tends more effective "hot tumors" characterized by a high abundant cells. Our previous studies found that secretagogin (SCGN) showed intranuclear aggregation early stages clear cell renal carcinoma (ccRCC) development. However, with progression distant metastasis ccRCC, expression SCGN gradually absent....
Cuproptosis is a newly discovered type of cell death. The role and potential mechanism Cuproptosis-related genes (CRGs) in the prognosis cancer patients are not fully understood. In this study, we included two cohorts clear renal carcinoma patients, TCGA E-MTAB-1980. cohort used as training set to construct CRG signature using LASSO-cox regression analysis, E-MTAB-1980 for verification. A total eight (FDX1, LIAS, LIPT1, DLAT, PDHA1, MTF1, GLS, CDKN2A) were screened prognostic model cohort....
Abstract Background : Molecular biomarkers combined with histopathological examination are of critical importance in the diagnosis and treatment clear cell renal carcinoma (ccRCC). The occurrence development ccRCC is closely related to abnormal E3 ubiquitin enzyme. Although recent studies have revealed that Ring Finger Protein 180 (RNF180)，known as an ubiquitination enzyme, could regulate proliferation, differentiation different cancers, precise role RNF180 cancer remains be elucidated....
Abstract Background: Lactic acid was previously considered a waste product of glycolysis, and has now become key metabolite for cancer development, maintenance metastasis. So far, numerous studies have confirmed that tumor lactic levels are associated with increased metastasis, recurrence poor prognosis. However, the prognostic value metabolism transporter related genes in patients clear cell renal carcinoma not been explored. Results: We selected twenty-one LASSO cox regression analysis...