A5101517854- Cancer Treatment and Pharmacology
- Microbial Natural Products and Biosynthesis
- Synthetic Organic Chemistry Methods
- Natural product bioactivities and synthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Sesquiterpenes and Asteraceae Studies
- Phytochemistry and Biological Activities
- Phytochemical compounds biological activities
- Plant Toxicity and Pharmacological Properties
- Traditional and Medicinal Uses of Annonaceae
- Essential Oils and Antimicrobial Activity
- Chemical synthesis and alkaloids
- Mesoporous Materials and Catalysis
- Plant biochemistry and biosynthesis
- Marine Sponges and Natural Products
- Bioactive Compounds and Antitumor Agents
- Pineapple and bromelain studies
- Plant-derived Lignans Synthesis and Bioactivity
- Bioactive Natural Diterpenoids Research
- 14-3-3 protein interactions
- Plant and animal studies
- Cocoa and Sweet Potato Agronomy
- Plant-based Medicinal Research
- Phytochemical Studies and Bioactivities
- Fungal Biology and Applications
Langfang Normal University
2025
Nanjing Boiler and Pressure Vessel Inspection Institute
2024
Hebei Medical University
2013-2022
Shenyang Agricultural University
2018-2022
Jiangxi University of Traditional Chinese Medicine
2022
Shijiazhuang University
2021
Queen's University
2003-2015
Hebei Chemical and Pharmaceutical College
2005-2015
Okayama University
2015
Handan College
2015
Abstract The Chloranthaceae is a small family with only four genera ( Ascarina, Chloranthus, Hedyosmum, Sarcandra ), of which nearly 70 species are distributed around the world. Chemical constituents in plants, especially sesquiterpenes, have attracted great deal attention recent 5 years. Many characteristic this may be responsible for anti-microbial, anti-tumor and other activities. In order to provide information future research, structures biological activities known from plants been...
Echinopines A (1) and B (2), novel sesquiterpenoids with an unprecedented rearranged skeleton named echinopane, were isolated from the roots of Echinops spinosus. The structures elucidated by extensive spectroscopic analysis. relative configuration 1 was assigned a combination NOESY correlations simulation plausible biosynthetic pathway for echinopane discussed.
Daphniphyllum alkaloids are a growing group of secondary metabolites great structural diversity, with complex polycyclic skeletons from plants. A large number new novel frameworks have been isolated species in the past decade. These unusual characteristics will attract attention scientists fields organic synthesis, bioactivity evaluation and biosynthetic studies. This review lists all as well their biosynthesis, synthesis reported by end first half 2008. Keywords: Daphniphyllum, alkaloids,...
Expression of metastatic suppressor maspin is lost in advanced prostate cancer. Clinically relevant mutations androgen receptor (AR) convert antiandrogens into AR agonists, promoting tumor growth. We discovered tanshinone IIA (TS-IIA) a potent antagonist mutated ARs and induces expression through AR. TS-IIA suppressed induced apoptosis LNCaP cells. Syntheses derivatives (1–9) revealed that the 4,4-dimethyl group at ring A important for TS-IIA's antiandrogenic induction activities.
A phytochemical investigation of Chromolaena odorata resulted in the isolation five new compounds, 5aα,6,9,9aβ,10-pentahydro-10β-hydroxy-7-methylanthra[1,2-d][1,3]dioxol-5-one (1), 1,2-methylenedioxy-6-methylanthraquinone (2), 3-hydroxy-1,2,4-trimethoxy-6-methylanthraquinone (3), 3-hydroxy-1,2-dimethoxy-6-methylanthraquinone (4), and 7-methoxy-7-epi-medioresinol (5), together with 12 known odoratin (6), 3β-acetyloleanolic acid (7), ursolic (8), ombuin (9),...
Abstract The genus Saussurea (Asteraceae) contains about 400 species distributed around Asia and Europe used in the traditional medicines of many cultures. main compounds isolated from are terpenoids, particular, sesquiterpenoids dominant. This review lists 404 chemical constituents as well their biological activity (111 references).
Long-term monoculture cropping and overfertilization degrade soil fertility, which reduces crop growth promotes the development of soil-borne diseases. However, it remains unclear what temporal effects above factors are on tomato yield microbial community structure. Thus, a greenhouse experiment with different amounts fertilization [2,196 kg ha −1 (control) 6,588 (overfertilization) inorganic fertilizers (NPK)] was carried out soils used previously for 1, 2, 12 years under tomato. A 12-year...
Achillinin A (2β,3β-epoxy-1α,4β,10α-trihydroxyguai-11(13)-en-12,6α-olide, 1), a new guaianolide isolated from the flower of Achillea millefolium, exhibited potential antiproliferative activity to A549, RERF-LC-kj and QG-90 cells with 50% inhibitory concentration (IC(50)) values 5.8, 10 0.31 µM, respectively.
3 Eight sesquiterpene lactones were isolated from the roots of Inula helenium and fl owers I. japonica. Among them, isoalantolactone () santamarine ( 6 ) exhibited significant growth inhibitory activities against gynecologic cancer cell lines, while others weakly inhibited lines (IC50 ≤ 100 μM). In addition, significantly tumour S180 tumour-bearing mice. Compounds not toxic to human embryonic lung fibroblast cells in vitro. These results demonstrated that antitumour are closely related...
Abstract The genus Ajuga , a member of the Lamiaceae family, is comprised more than 300 species annual and perennial herbaceous flowering plants mainly distributed throughout temperate regions Asia, Europe, Australia, North America Africa. These are used as folk medicines effective for rheumatic fevers, dysentery, malaria, hypertension, diabetes gastrointestinal disorders, well anthelmintic, astringent, febrifuge diuretic, antifungal anti-inflammatory agents. A variety constituents has been...