A5015591069- Thermodynamic and Exergetic Analyses of Power and Cooling Systems
- Refrigeration and Air Conditioning Technologies
- Advanced Thermodynamic Systems and Engines
- Cancer Treatment and Pharmacology
- Advanced Thermodynamics and Statistical Mechanics
- Microbial Natural Products and Biosynthesis
- Natural product bioactivities and synthesis
- Sesquiterpenes and Asteraceae Studies
- Phytochemistry and Biological Activities
- Synthetic Organic Chemistry Methods
- Plant Toxicity and Pharmacological Properties
- Natural Compound Pharmacology Studies
- Phase Equilibria and Thermodynamics
- Carbon Dioxide Capture Technologies
- Phytochemical compounds biological activities
- Spacecraft and Cryogenic Technologies
- Bioactive Compounds and Antitumor Agents
- DNA Repair Mechanisms
- Heat transfer and supercritical fluids
- Phytochemistry and Bioactivity Studies
- Plant-derived Lignans Synthesis and Bioactivity
- Phytochemistry and Bioactive Compounds
- Effects of Radiation Exposure
- Adsorption and Cooling Systems
- Ultrasound and Hyperthermia Applications
Tianjin University
2018-2024
Hebei Medical University
2001-2019
Molecular Oncology (United States)
2007
Hebei Chemical and Pharmaceutical College
2005
Memorial Sloan Kettering Cancer Center
1996-2001
Rockefeller University
1997
Henan Cancer Hospital
1989
We recently have shown that mice deficient for the 86-kDa component (Ku80) of DNA-dependent protein kinase exhibit growth retardation and a profound deficiency in V(D)J (variable, diversity, joining) recombination. These defects may be related to abnormalities DNA metabolism arise from inability Ku80 mutant cells process double-strand breaks. To further characterize role break repair, we generated embryonic stem pre-B examined their response ionizing radiation. −/− are more sensitive than...
A phytochemical investigation of Chromolaena odorata resulted in the isolation five new compounds, 5aα,6,9,9aβ,10-pentahydro-10β-hydroxy-7-methylanthra[1,2-d][1,3]dioxol-5-one (1), 1,2-methylenedioxy-6-methylanthraquinone (2), 3-hydroxy-1,2,4-trimethoxy-6-methylanthraquinone (3), 3-hydroxy-1,2-dimethoxy-6-methylanthraquinone (4), and 7-methoxy-7-epi-medioresinol (5), together with 12 known odoratin (6), 3β-acetyloleanolic acid (7), ursolic (8), ombuin (9),...
Abstract The supercritical CO 2 (sCO ) power cycle could improve efficiencies for a wide range of thermal plants. sCO turbine generator plays an important role in the by directly converting energy into mechanical work and electric power. operation encounters challenges, including high temperature, pressure, rotational speed, other engineering problems, such as leakage. Experimental studies turbines are insufficient because significant difficulties manufacturing system construction. Unlike...
Forsythia suspensa (Thunb.) Vahl leaves have been consumed in China as a health-promoting functional tea for centuries. Three new polyhydroxytriterpenoid glycosides named suspensanosides A–C (1–3), seven known polyhydroxytriterpenoids (4–10), and 12 phenolics (11–22) were identified from F. leaves. Compounds 1–10, 15–17, 22 not found the genus previously, whereas compound 14 was first reported to be isolated of suspensa. All isolates tested their antiproliferative activities on BGC-823 MCF-7...
Previously, we proposed a dual control mechanism for the regulation of heat shock response in mammalian cells: positive mediated by transcription factor HSF1 and negative constitutive element-binding (CHBF). To study physiological role CHBF response, purified to apparent homogeneity showed it be identical Ku autoantigen, heterodimer consisting 70-kDa (Ku-70) 86-kDa (Ku-80) polypeptides. further functional significance Ku/CHBF cellular shock, established rodent cell lines that stably...
Abstract Ku70 is one component of a protein complex, the Ku70/Ku80 heterodimer, which binds to DNA double-strand breaks and activates DNA-dependent kinase (DNA-PK), leading damage repair. Our previous work has confirmed that important for repair in deficiency compromises ability cells breaks, increases radiosensitivity cells, enhances radiation-induced apoptosis. Because radioresistance some human cancers, particularly glioblastoma, we examined use radio-gene therapy paradigm sensitize...