A5070172874- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Sleep and related disorders
- Memory and Neural Mechanisms
- Olfactory and Sensory Function Studies
- Physiological and biochemical adaptations
- Eicosanoids and Hypertension Pharmacology
- Autism Spectrum Disorder Research
- Receptor Mechanisms and Signaling
- Fatty Acid Research and Health
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Insect and Arachnid Ecology and Behavior
Otto-von-Guericke University Magdeburg
2020-2023
Leibniz Institute for Neurobiology
2017-2018
Charité - Universitätsmedizin Berlin
2017
TH Bingen University of Applied Sciences
2017
Essen University Hospital
2017
Martin-Luther-Krankenhaus
2017
University of Münster
2017
Universität Hamburg
2017
University Medical Center Hamburg-Eppendorf
2017
The brain adaptively integrates present sensory input, past experience, and options for future action. insect mushroom body exemplifies how a central structure brings about such integration. Here we use combination of systematic single-cell labeling, connectomics, transgenic silencing, activation experiments to study the at resolution, focusing on behavioral architecture its input output neurons (MBINs MBONs), intrinsic APL neuron. Our results reveal identity morphology almost all these 44...
Cognitive flexibility is an important executive function and refers to the ability adapt behaviors in response changes environment. Of note, many brain disorders are associated with impairments cognitive flexibility. Several classical neurotransmitter systems including dopamine, acetylcholine noradrenaline shown be for flexibility, however, there not much known about role of neuropeptides. The neuropeptide orexin, which brain-widely released by neurons lateral hypothalamus, a major player...
Brain-derived neurotrophic factor (BDNF) is implicated in a number of processes that are crucial for healthy functioning the brain. Schizophrenia associated with low BDNF levels brain and blood, however, not much known about BDNF's role different symptoms schizophrenia. Here, we used BDNF-haploinsufficient (BDNF+/-) mice to investigate mouse behavioral endophenotypes Furthermore, assessed if an enriched environment can prevent observed changes. In this study, male mature adult wild-type...
ABSTRACT Avoiding associatively learned predictors of danger is crucial for survival. Aversive memories can, however, become counter-adaptive when they are overly generalized to harmless cues and contexts. In a fruit fly odor–electric shock associative memory paradigm, we found that avoidance lost its specificity the trained odor became general novel odors within day training. We discuss possible neural circuit mechanisms this effect highlight parallelism over-generalization fear behavior...
Sex difference has been reported in several behavioural endophenotypes of neuropsychiatric disorder both rodents and humans. However, sex cognitive symptoms associated with disorders not studied detail. In this study, we induced impairment using the NMDA receptor antagonist, dizocilpine (MK-801), male female C57BL/6J mice performed a visual discrimination task an automated touchscreen system. We found that performance decreased increased doses MK-801 sexes. showed stronger deficit than...
Orexin neuropeptides are well known for their role in sleep/wake cycle, feeding behavior and motivation-related behaviors. However, cognition is not clearly understood. We recently published that orexin deficiency impairs intra-dimensional set shifting female homozygous orexin-deficient mice but improves the first reversal phase male attentional task (ASST), a well-established rodent test cognitive flexibility. In present study, we tested if intracerebroventricular injections of selective 1...