A5065861449- Mass Spectrometry Techniques and Applications
- Nanocluster Synthesis and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Chemical Physics Studies
- Advanced Nanomaterials in Catalysis
- Spectroscopy and Quantum Chemical Studies
- Analytical Chemistry and Chromatography
- Ion-surface interactions and analysis
- Advanced Proteomics Techniques and Applications
- Molecular Junctions and Nanostructures
- Quantum Dots Synthesis And Properties
- Protein Structure and Dynamics
- Photochemistry and Electron Transfer Studies
- Atomic and Molecular Physics
- Analytical chemistry methods development
- Microfluidic and Capillary Electrophoresis Applications
- Photoreceptor and optogenetics research
- Nonlinear Optical Materials Studies
- Alzheimer's disease research and treatments
- Fullerene Chemistry and Applications
- DNA and Nucleic Acid Chemistry
- Laser-Ablation Synthesis of Nanoparticles
- Electrohydrodynamics and Fluid Dynamics
- Lanthanide and Transition Metal Complexes
- Nanoparticle-Based Drug Delivery
Université Claude Bernard Lyon 1
2016-2025
Centre National de la Recherche Scientifique
2016-2025
Institut Lumière Matière
2016-2025
Laboratoire des Biomolécules
2019-2023
Mahatma Gandhi University
2023
Forum Réfugiés - Cosi
2014-2021
Lyon College
2019-2021
Bipar
2015-2019
Institut des Sciences Analytiques
2016
Université de Lyon
2010-2014
We present the first direct measurement of electric polarizability isolated C60 molecules by molecular beam deflection technique. have obtained a value 76.5±8.0 Å3 which is consistent with most recent calculations and slightly lower than measured in fullerite crystals.
Small angle X-ray scattering (SAXS), electrospray ionization charge detection mass spectrometry (CD-MS), dynamic light (DLS), and transmission electron microscopy (TEM) are used to characterize poly(glycerol monomethacrylate)55-poly(2-hydroxypropyl methacrylate)x (G55-Hx) vesicles prepared by polymerization-induced self-assembly (PISA) using a reversible addition-fragmentation chain transfer (RAFT) aqueous dispersion polymerization formulation. A G55 agent is utilized prepare series of...
Ultrasmall but multifunctional: Rigid imaging particles that are smaller than 5 nm in size can be obtained a top-down process starting from core–shell structure (core=gadolinium oxide; shell=polysiloxane). They represent the first multifunctional silica-based sufficiently small to escape hepatic clearance and enable animal by four complementary techniques. Detailed facts of importance specialist readers published as "Supporting Information". Such documents peer-reviewed, not copy-edited or...
The present paper describes the successful one-pot synthesis of self-stabilized particles composed amphiphilic block copolymers based on poly(methacrylic acid) (PMAA) obtained by polymerization-induced self-assembly. First, controlled radical polymerization MAA is performed in water using RAFT process taking advantage our recent results showing [ChaducMacromolecules 2012, 45, 1241−1247]. so-formed hydrophilic macroRAFT agents are then chain-extended situ with a hydrophobic monomer to form...
We previously reported the synthesis of gadolinium-based nanoparticles (NPs) denoted AGuIX (activation and guiding irradiation by X-ray) NPs demonstrated their potential as an MRI contrast agent efficacy radiosensitizing particles during X-ray cancer treatment. Here we focus on elimination kinetics from subcellular to whole-organ scale using original complementary methods such laser-induced breakdown spectroscopy (LIBS), intravital two-photon microscopy, inductively coupled plasma optical...
Abstract New, ultrasmall nanoparticles with sizes below 5 nm have been obtained. These small rigid platforms (SRP) are composed of a polysiloxane matrix DOTAGA (1,4,7,10‐tetraazacyclododecane‐1‐glutaric anhydride‐4,7,10‐triacetic acid)–Gd 3+ chelates on their surface. They synthesised by an original top‐down process: 1) formation gadolinium oxide Gd 2 O 3 core, 2) encapsulation in shell grafted ligands, 3) dissolution the core due to chelation ligands and 4) fragmentation. fully...
Optical spectroscopy has contributed enormously to our knowledge of the structure and dynamics atoms molecules is now emerging as a cornerstone gas phase methods available for investigating biomolecular ions. This article focuses on UV visible peptide protein ions stored in ion traps, with emphasis placed recent results obtained polyanions, by electron photodetachment experiments. We show that among large number possible de-excitation pathways, relaxation polyanions mainly achieved emission...
We developed a new method for synthesizing atomically monodisperse Au<sub>15</sub> nanoclusters stabilized with glutathione molecules, and investigated their nonlinear optical (NLO) properties after two-photon absorption.
For the first time, electrospray ionization efficiency (IE) scales in positive and negative mode are united into a single system enabling direct comparison of IE values across modes. This is made possible by use reference compound that ionizes to similar extent both Thus, choosing optimal (i.e., most sensitive) conditions for given set analytes enabled. Ionization efficiencies 33 compounds ionizing modes demonstrate that, contrary general practice, allows better sensitivity 46% such whereas...
The extinction profiles as well the hyper Rayleigh scattering signal of a highly monodisperse 22 nm diameter gold colloidal sol in presence pyridine have been measured. A strong enhancement HRS is observed small amounts pyridine. relationship between spectra, distribution aggregated particles, and second harmonic response has investigated by evaluating factor electromagnetic field colloids they slowly aggregate. It also shown that at larger concentrations, levels off owing to formation large...
We hereby explore the effects of irradiating DNA polyanions stored in a quadrupole ion trap mass spectrometer with an optical parametric oscillator laser between 250 and 285 nm. studied 6-20-mer single strands 12-base pair double strands. In all cases, irradiation causes electron detachment from multiply charged anions. Electron photodetachment efficiency directly depends on number guanines strand, maximum is observed 260 275 Subsequent collision-induced dissociation (CID) radical anions...
DNA multiply charged anions stored in a quadrupole ion trap undergo one-photon electron ejection (oxidation) when subjected to laser irradiation at 260 nm (4.77 eV). Electron photodetachment is likely fast process, given that able compete with internal conversion or radiative relaxation the ground state. The [6-mer]3- ions studied here show marked sequence dependence of yield. Remarkably, yield (dG6 > dA6 dC6 dT6) inversely correlated base ionization potentials (G < A C T). Sequences guanine...
We used ion mobility spectrometry to explore conformational adaptability of intrinsically disordered proteins bound their targets in complex mixtures. investigated the interactions between a human salivary proline-rich protein IB5 and model wine tea tannin: epigallocatechin gallate (EgCG). Collisional cross sections naked complexed with N = 1–15 tannins were recorded. The data demonstrate that undergoes an unfolded folded structural transition upon binding EgCG.
We report a simple synthesis of silver:glutathione (Ag:SG) clusters using cyclic reduction under oxidative conditions. Two syntheses are described which lead to solutions containing well-defined Ag31(SG)19 and Ag15(SG)11 that have been characterized by mass spectrometry. The optical properties cluster investigated experimentally. In particular, the solution shows bright photostable emission. For clusters, comparison experimental findings with DFT TDDFT calculations allowed us reveal...
We demonstrate that the tuning of light emission from red to blue in dihydrolipoic acid (DHLA) capped Ag29 nanoclusters can be trigged with one and two photon excitations. The cluster stoichiometry was determined mass spectrometry found Ag29(DHLA)12. In a detailed optical investigation, we show these silver exhibit strong photoluminescence visible naked eye characterized by quantum yield nearly ∼2% upon one-photon excitation. nonlinear (NLO) study properties clusters, two-photon excited...
Abstract Metalloenzymes preorganize the reaction environment to steer substrate(s) along required coordinate. Here, we show that phosphine ligands selectively facilitate protonation of binuclear silver hydride cations, [LAg 2 (H)] + by optimizing geometry active site. This is a key step in selective, catalysed extrusion carbon dioxide from formic acid, HO CH, with important applications (for example, hydrogen storage). Gas-phase ion-molecule reactions, collision-induced dissociation (CID),...
Electrospray (ESI) ionization efficiencies (IE) of a set 10 compounds differing by chemical nature, extent in solution (basicity), and hydrophobicity (tetrapropylammonium tetraethylammonium ion, triethylamine, 1-naphthylamine, N,N-dimethylaniline, diphenylphthalate, dimethylphtahalate, piperidine, pyrrolidine, pyridine) have been measured seven mobile phases (three acetonitrile percentages 20%, 50%, 80%, three different pH-adjusting additives, 0.1% formic acid, 1 mM ammonia, pH 5.0 buffer...
Ligated silver and gold nanoclusters belonging to a non-scalable size regime with molecular-like discrete electronic states represent an emerging class of extremely interesting optical materials.
Random lasers are a particular class of optical devices where the feedback is provided by scattering media. In this review, we discuss recent progress and prospects random using advanced materials.
We have coupled a quadrupole ion trap with frequency doubled optical parametric oscillator laser. The photodissociation spectrum of the protonated tryptophan from 215 to 320 nm is reported. yields fragmentation on each mass channel as function laser wavelength were obtained. also report experiments involving multiple stages induced dissociation and discuss possible structures for products.
The relative performances of different implementations the Wang-Landau method are assessed on two classes systems with continuous degrees freedom, namely, polypeptides and atomic Lennard-Jones clusters. Parallel tempering Monte Carlo simulations serve as a reference, we pay particular attention to variations multiplicative factor f during course simulation. For studied, is found be comparable accuracy parallel tempering, but has significant difficulties in reproducing low-temperature...
Ions from compounds of megadalton (MDa) molecular weight were produced in an electrospray ionization source solutions poly(ethylene oxide) (PEO) samples with average weights ranging 1,000,000 to 7,000,000 Da. Charge detection mass spectrometry (CDMS) has been used determine the MDa PEOs. Simultaneous measurement charge and velocity individual ions allows determination ion, after calibration instrument independent samples. In addition spectra, CDMS generates charge-versus-mass plots, which...