A5086253408- Mast cells and histamine
- Characterization and Applications of Magnetic Nanoparticles
- Virology and Viral Diseases
- Chemical Synthesis and Analysis
- Receptor Mechanisms and Signaling
- Fluid Dynamics and Vibration Analysis
- Hepatitis B Virus Studies
- Plant Virus Research Studies
- Vector-Borne Animal Diseases
- Vascular Tumors and Angiosarcomas
- Histiocytic Disorders and Treatments
- Vascular Malformations and Hemangiomas
- Viral Infections and Outbreaks Research
- Lattice Boltzmann Simulation Studies
- Viral gastroenteritis research and epidemiology
Shunyi Hospital of Beijing Traditional Chinese Medicine Hospital
2024
Tianjin University
2024
Zhejiang University
2022
Abstract The histamine receptors belong to the G protein-coupled receptor (GPCR) superfamily, and play important roles in regulation of other neurotransmitters central nervous system, as potential targets for treatment neurologic psychiatric disorders. Here we report crystal structure human H 3 R bound an antagonist PF-03654746 at 2.6 Å resolution. Combined with computational functional assays, our reveals binding modes allosteric cholesterol. Molecular dynamic simulations molecular docking...
Abstract The Hendra and Nipah viruses (HNVs) are highly pathogenic pathogens without approved interventions for human use. In addition, the interaction pattern between attachment (G) fusion (F) glycoproteins required virus entry remains unclear. Here, we isolate a panel of Macaca-derived G-specific antibodies that cross-neutralize HNVs via multiple mechanisms. most potent antibody, 1E5, confers adequate protection against challenge in female hamsters. Crystallography demonstrates 1E5 has...
Orthoebolavirus is a genus of hazardous pathogens that has caused over 30 outbreaks. However, currently approved therapies are limited in scope, as they only effective against the Ebola virus and lack cross-protection other orthoebolaviruses. Here, we demonstrate previously isolated human-derived antibody, 2G1, can recognize glycoprotein (GP) every orthoebolavirus species. The cryo-electron microscopy structure 2G1 Fab complex with GPΔMucin trimer reveals binds quaternary pocket formed by...
Background: Juvenile xanthogranuloma is a rare condition, and femoral involvement even rarer. We report case of juvenile affecting the femur. To best our knowledge, this first reported in China. Case Presentation: A 19-year-old boy began experiencing swelling various parts his body at age 1 year, followed by pain left hip. Preoperative pathology imaging indicated femur, leading to surgical intervention. Postoperatively, patient experienced significant relief from hip discomfort. Conclusion:...
Flow separation can lead to increased resistance and vibration generation, which is a difficult problem that cannot be ignored in engineering. In this paper, we propose method of controlling flow by adsorbing ferrofluid onto the surface magnetized cylinder, taking common around cylinder as an example. Parametric effects film, including its viscosity thickness, on behavior were investigated terms vortex shedding process, velocity distribution, dominant frequency, pressure motion inside film....