A5038381762- Carbohydrate Chemistry and Synthesis
- Synthetic Organic Chemistry Methods
- Microbial Natural Products and Biosynthesis
- Cholinesterase and Neurodegenerative Diseases
- Enzyme Production and Characterization
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Biological Evaluation
- Synthesis and properties of polymers
- Inflammatory mediators and NSAID effects
- Organoselenium and organotellurium chemistry
- Estrogen and related hormone effects
- Monoclonal and Polyclonal Antibodies Research
- Advanced biosensing and bioanalysis techniques
- Natural Antidiabetic Agents Studies
- Lipid metabolism and biosynthesis
- Effects and risks of endocrine disrupting chemicals
- Marine Sponges and Natural Products
- Membrane-based Ion Separation Techniques
- Advanced Drug Delivery Systems
- Microstructure and mechanical properties
- Nanocomposite Films for Food Packaging
- Traditional and Medicinal Uses of Annonaceae
- Legume Nitrogen Fixing Symbiosis
- Bioactive Compounds and Antitumor Agents
- Click Chemistry and Applications
Jianghan University
2015-2023
University of Chinese Academy of Sciences
2012-2017
Chinese Academy of Sciences
2012-2017
Research Center for Eco-Environmental Sciences
2012-2017
Ministry of Education of the People's Republic of China
2015-2016
Lanzhou Petrochemical Polytechnic
2011
Fuzanin D, a pyridine-containing natural product, which exhibits cytotoxic activity against DLD-1 cells, is synthesized in concise manner using <sc>l</sc>-arabinose or ethyl <sc>l</sc>-lactate as chiral pool substrates nine steps (14.4% overall yield) and six (30.8% yield), respectively. The key involve Wittig olefination olefin cross-metathesis.
A bicomponent anion exchange membrane (AEM) in the form of poly(vinylbenzyl chloride) (PVBC) cross-linked by polybenzimidazole (PBI) and quaternized N-methylpiperidine (NMPD) is provided. On one hand, cross-linking between benzimidazole moiety PBI chloromethyl group PVBC increases compatibility two components without macroscopic phase separation. other difference hydrophilic NMPD-functionalized hydrophobic leads to microphase separation results construction continuous ion transport channels...
Abstract Divergent syntheses of two 14‐membered resorcylic acid lactones (RALs), cochliomycin B ( 6 ) and zeaenol 22 ), have been accomplished. The key feature in our strategy was the facile construction three contiguous stereogenic centers title molecules by using natural L ‐arabinose as chiral template. reactions included Takai olefination, Suzuki cross coupling, transesterification, a late‐stage ring‐closing metathesis (RCM).
The efficient and concise synthesis of (-)-orthodiffenes A C has been accomplished for the first time in eight steps from readily available chiral synthons, D-mannose D-ethyl lactate. Our work confirmed complete structure orthodiffenes C, including their absolute stereochemistry. key our total involved cis-fused tetrahydrofuran cyclization, one-pot deprotection-lactonization, intramolecular benzoyl migration according to a biosynthetic hypothesis orthodiffenes.
Sphingolipids and their derivatives, such as glycosphingolipids sphingomyelins, are ubiquitous in the biomembrane of eukaryotic cells, they play pivotal roles cell proliferation, recognition, adhesion, signal transduction. Sphingosine is predominantly important lipid moiety while phytosphingosine a major long-chain for glycosphingolipids. Due to significance these two bioactive lipids, tremendous efforts have been made synthesize sphingosine or phytosphingosine, with chiral pool approaches,...
Chitosan is the second-most abundant natural polysaccharide. It has unique characteristics, such as biodegradability, biocompatibility, and non-toxicity. Due to existence of its free amine group hydroxyl groups on backbone chain, chitosan can undergo further chemical modifications generate Derivatives (CDs) that permit additional biomedical functionality. CDs be fabricated into various forms, including Nanoparticles (NPs), micelles, hydrogels, nanocomposites nano-chelates. For these reasons,...
Penarolide sulfate A2, a 31-membered macrolide encompassing proline residue and three groups, was firstly synthesized in 16 linear steps with 4.8% overall yield. Three consecutive stereogenic centers penarolide A2 were efficiently derived from natural chiral template L-arabinose. The crucial assembly reactions included Brown asymmetric allylation, olefin cross-metathesis, alkyne-epoxide coupling, macrolactamization. anti-yeast α-glucosidase activities of its fully desulfated derivative...
The total synthesis of putative penasulfate A was effectively achieved by a convergent strategy with longest linear sequence 14 steps and overall yield 8.6%. highlights our involved an E-selective olefin cross-metathesis, Suzuki cross-coupling, copper(I)-catalyzed coupling reaction.
The performance of Ag-8.5Au-3.5Pd alloy wire after cold deformation and annealing were analyzed by SEM (scanning electron microscope), strength tester resistivity tester. processing process change characteristics studied. results show that grains gradually form a fibrous structure along with the increase in deformation. increases rate, but trend becomes flat once rate is higher than 92.78%; decreases temperature, reaching minimum (2.395 × 10−8 Ω·m) when temperature 500 °C; temperature. When...
Abstract: α-Glucosidase inhibitors (AGIs) showcase versatile biochemical activities with respect to antidiabetic, anticancerous, antiobese and antiviral effects. They have drawn a great deal of attention from the scientific community. While α-glucosidase are mostly discovered plants microorganisms, recent advance in natural αglucosidase over past five years has been reviewed this article, 139 distinct microorganisms were classified into ten groups based on their chemical structures,...
Abstract As an important branch of halogenated bisphenol compounds, the monosubstituted‐ether compounds have received a lot attention in environmental health science because their toxicity and variability. In this study, synthetic method for byproduct libraries was developed. By using versatile efficient method, tetrachlorobisphenol A, tetrabromobisphenol S monosubstituted alkyl‐ether were accessed 39–82 % yield. Subsequently, cytotoxicity 27 screened three different cell lines (HepG2, mouse...
Abstract The stereoselective synthesis of the title compound (I) from L‐arabinose is reported.