A5025859050- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Diet and metabolism studies
- Epigenetics and DNA Methylation
- Redox biology and oxidative stress
- Glutathione Transferases and Polymorphisms
- Virus-based gene therapy research
- Histone Deacetylase Inhibitors Research
- Cancer Research and Treatments
- Characterization and Applications of Magnetic Nanoparticles
- Nanoparticle-Based Drug Delivery
- Mitochondrial Function and Pathology
University of Duisburg-Essen
2023-2024
Weatherford College
2023
Essen University Hospital
2022-2023
Max Planck Institut für Zellbiologie
2023
Lomonosov Moscow State University
2018-2019
Abstract Metabolic rewiring is the result of increasing demands and proliferation cancer cells, leading to changes in biological activities responses treatment cells. The mitochondrial citrate transport protein SLC25A1 involved metabolic reprogramming offering a strategy induce bottlenecks relevant radiosensitization through accumulation oncometabolite D-2-hydroxyglutarate (D-2HG) upon inhibition (SLC25A1i). Previous studies have revealed comparative effects SLC25A1i or cell-permeable D-2HG...
Magnetic resonance imaging (MRI) is a powerful technique for tumor diagnostics. Iron oxide nanoparticles (IONPs) are safe and biocompatible tools that can be used further enhancing MR contrasting. Although numerous IONPs have been proposed as MRI contrast agents, low delivery rates to site limit its application. accumulation in malignancies depends on both characteristics properties. In the current paper, three differently shaped Pluronic F-127-modified (nanocubes, nanoclusters, nanorods)...
Aberrant activation of the phosphatidyl-inositol-3-kinase/protein kinase B (AKT) pathway has clinical relevance to radiation resistance, but underlying mechanisms are incompletely understood. Protection against reactive oxygen species (ROS) plays an emerging role in regulation cell survival upon irradiation. AKT-dependent signaling participates cellular antioxidant defense. Here, we were interested explore a yet unknown aberrant AKT regulating defense response IR and associated resistance....
Abstract Metabolic rewiring is the result of growing demands and proliferation cancer cells, leading to alterations biological activities reactions treatments cells. The mitochondrial citrate transport protein SLC25A1 involved in metabolic reprogramming offering a strategy induce bottlenecks with relevance for radiosensitization by accumulation oncometabolite D-2-hydroxyglutarate (D-2HG) upon inhibition (SLC25A1i). Previous studies have uncovered comparative effects SLC25A1i or cell...