A5063883661- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Advanced Breast Cancer Therapies
- Antibiotic Resistance in Bacteria
- Bacteriophages and microbial interactions
- Infections and bacterial resistance
- Multiple and Secondary Primary Cancers
- Bacterial Genetics and Biotechnology
- Monoclonal and Polyclonal Antibodies Research
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Pediatric Hepatobiliary Diseases and Treatments
- Urinary and Genital Oncology Studies
- FOXO transcription factor regulation
- Inflammatory Biomarkers in Disease Prognosis
- RNA and protein synthesis mechanisms
- Bacterial biofilms and quorum sensing
- Breast Cancer Treatment Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Cancer therapeutics and mechanisms
- Reproductive Biology and Fertility
- Immune Cell Function and Interaction
- Blood disorders and treatments
- Ovarian function and disorders
- Lung Cancer Research Studies
Centro de Investigación Biomédica en Red de Cáncer
2018-2022
Research Institute Hospital 12 de Octubre
2018-2022
Centro Nacional de Biotecnología
2013-2020
Molecular Oncology (United States)
2019
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas
2018-2019
Unidades Centrales Científico-Técnicas
2018
Consejo Superior de Investigaciones Científicas
2013-2015
National University of Mar del Plata
2011
Universidad La República
2011
Consejo Nacional de Investigaciones Científicas y Técnicas
2011
Intrinsically resistant bacteria have emerged as a relevant health problem in the last years. Those bacterial species, several of them with an environmental origin, present naturally low-level susceptibility to drugs. It has been proposed that intrinsic resistance is mainly consequence impermeability cellular envelopes, activity multidrug efflux pumps or lack appropriate targets for given family However, recently published articles indicate characteristic phenotype antibiotics species...
RNA preparations containing 70-80% mouse kappa-chain mRNA have been prepared. The remainder consists of many species, each which represents a small fraction the total RNA. preparation hybridizes with liver DNA bi-phasic kinetics, indicating that it two fractions -"unique" and "reiterated." Competition hybridization experiments show homology among unique from different mRNAs is same as amino acid sequences corresponding kappa-chains. Hence, in addition to C-region (constant-region) sequences,...
Abstract Purpose: Bladder cancer is a clinical and social problem due to its high incidence recurrence rates. It frequently appears in elderly patients showing other medical comorbidities that hamper the use of standard chemotherapy. We evaluated activity CDK4/6 inhibitor as new therapy for unfit cisplatin (CDDP). Experimental Design: cell lines were tested vitro sensitivity inhibition. A novel metastatic bladder mouse model was developed used test vivo activity. Results: Cell sensitive...
High-grade neuroendocrine lung malignancies (large-cell cell carcinoma, LCNEC, and small-cell SCLC) are among the most deadly cancer conditions with no optimal clinical management. The biological relationships between SCLC LCNEC still largely unknown a current matter of debate as growing molecular data reveal high heterogeneity potential therapeutic consequences. Here we describe murine models high-grade carcinomas generated by loss 4 tumor suppressors. In an Rbl1 -null background, deletion...
Platinum-based neoadjuvant chemotherapy followed by interval debulking surgery is an accepted treatment for patients with stage III or IV epithelial ovarian cancer who are not suitable primary surgery. The identification of adjuvant treatments in these unmet need. Here, we explore potential genomic characteristics (mutational and immune-associated expression profiles) a series undergoing chemotherapy. Tumor samples from biopsy were analyzed mutational landscape immune profiling, together...
Fosfomycin is a bactericidal antibiotic, analogous to phosphoenolpyruvate, that exerts its activity by inhibiting the of MurA. This enzyme catalyzes first step peptidoglycan biosynthesis, transfer enolpyruvate from phosphoenolpyruvate uridine-diphosphate-N-acetylglucosamine. increasingly being used, mainly for treating infections caused Gram-negative multidrug-resistant bacteria. The mechanisms mutational resistance fosfomycin in Stenotrophomonas maltophilia, an opportunistic pathogen...
The spatial distribution of signals downstream from receptor tyrosine kinases (RTKs) or G-protein coupled receptors (GPCR) regulates fundamental cellular processes that control cell migration and growth. Both pathways rely significantly on actin cytoskeleton reorganization mediated by nucleation-promoting factors such as the WASP-(Wiskott-Aldrich Syndrome Protein) family. WIP (WASP Interacting is essential for formation a class polarised microdomain, namely dorsal ruffles, RTK PDGF...
Quinolone resistance is usually due to mutations in the genes encoding bacterial topoisomerases. However different reports have shown that neither clinical quinolone resistant isolates nor vitro obtained S. maltophilia mutants present such genes. The mechanisms so far described consist on efflux pumps' overexpression. Our objective get information novel of resistance. For this purpose, a transposon-insertion mutant library was D457.. One presenting reduced susceptibility nalidixic acid...
Gene expression is determined by critical processes such as RNA synthesis and degradation. Ribonucleases participate in the coordinated differential decay of messenger RNAs. We describe a suitable method normalization calculation mRNAs half-life values quantified RNA-Seq. mRNA half-lives more than 2000 genes Stenotrophomonas maltophilia D457 an isogenic RNase G deficient mutant. Median were 2,74 3 min wild-type rng-deficient strain, respectively. The absence resulted overall enhancement...
Background and Aims: Metastatic urothelial carcinoma (mUC) remains an incurable disease with limited treatment options after platinum-based chemotherapy immune checkpoint blockade (ICB). Vinflunine has shown a modest increase in overall survival therapeutic option for chemo- immunotherapy refractory tumours. However, biomarkers that could identify responding patients to vinflunine possible alternative therapies failure are still missing. In this study, we aimed potential genomic of response...
Congenital hypopituitarism is a rare disease, of variable clinic. The neonatal hypoglycemia one the habitual forms presentation; cholestasis symptom this disease. This case 2-months-old infant hospitalized for cholestatic jaundice. He added repeated episodes severe hypoglycemia. We investigated metabolic and endocrine causes. etiology was clarified by obtaining critical sample that demonstrated counterregulatory hormone deficiency. diagnosis congenital completed with confirmation thyroid...
Abstract Fosfomycin is a bactericidal antibiotic, analogous to phosphoenolpyruvate (PEP) that exerts its activity by inhibiting the of MurA. This enzyme catalyzes first step peptidoglycan biosynthesis, transfer enolpyruvate from PEP uridine-diphosphate-N-acetylglucosamine. increasingly used in last years, mainly for treating infections caused Gram-negative multidrug resistant bacteria as Stenotrophomonas maltophilia , an opportunistic pathogen characterized low susceptibility antibiotics...
Abstract Introduction. The incorporation of cyclin-dependent kinase inhibitors 4 and 6 (CDK4/6 inhibitors) with endocrine therapy in patients hormone receptor-positive/HER2-negative (HR+/HER2-) advanced breast cancer has demonstrated its efficacy improving progression-free survival (PFS), overall response rate (ORR) and, more recently, (OS). However, eventually progress due to resistance treatment. To date, no clinical or molecular markers defining the HR+/HER2- patient population that...