A5028054823- Cancer-related Molecular Pathways
- NF-κB Signaling Pathways
- Cell death mechanisms and regulation
- Cancer-related gene regulation
- Kruppel-like factors research
- Hedgehog Signaling Pathway Studies
- Bladder and Urothelial Cancer Treatments
- Melanoma and MAPK Pathways
- Acute Kidney Injury Research
- Hippo pathway signaling and YAP/TAZ
- RNA modifications and cancer
- Virus-based gene therapy research
- Hair Growth and Disorders
- Advanced Breast Cancer Therapies
- PI3K/AKT/mTOR signaling in cancer
- Cancer Genomics and Diagnostics
- Drug-Induced Hepatotoxicity and Protection
- Phagocytosis and Immune Regulation
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- DNA Repair Mechanisms
- Cancer and Skin Lesions
- Lung Cancer Research Studies
- CRISPR and Genetic Engineering
- Cell Adhesion Molecules Research
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas
2015-2025
Centro de Investigación Biomédica en Red de Cáncer
2017-2024
Research Institute Hospital 12 de Octubre
2015-2024
Universidad Complutense de Madrid
1997-2024
Molecular Oncology (United States)
2009-2024
Instituto de Salud Carlos III
2022
Biomedical Research Institute
2020
Unidades Centrales Científico-Técnicas
2018
Hospital Universitario 12 De Octubre
2016
University of Iceland
2012
ABSTRACT. Paracetamol (also known as acetaminophen) causes acute and chronic renal failure. While the mechanisms leading to hepatic injury have been extensively studied, molecular of paracetamol-induced nephrotoxicity are poorly defined. induced cell death with features apoptosis in murine proximal tubular epithelial cells. paracetamol increased expression receptor Fas on surface, pathway was not involved The mitochondrial activated during apoptosis; there no dissipation potential or release...
<b>Objective:</b> To investigate the effects of cladribine on MRI disease activity measures in RRMS patients treated for 2 additional years beyond initial 2-year regimen (CLARITY). <b>Background:</b> In CLARITY, significantly reduced relapse rates, disease-activity and slowed disability progression. After a treatment gap (median 40 weeks), vs. placebo were investigated CLARITY-Extension (EXT); outcomes are described here. <b>Methods:</b> CLARITY randomized to years' with or (3.5 5.25mg/kg...
Apoptotic cell death contributes to diabetic nephropathy (DN), but its role is not well understood. The tubulointerstitium from DN biopsy specimens was microdissected, and expression profiles of genes related apoptosis were analyzed. A total 112 (25%) 455 death–related found be significantly differentially regulated. Among those that showed the greatest changes in regulation two receptors, <i>OPG</i> (the gene encoding osteoprotegerin) <i>Fas</i>, ligand <i>TRAIL.</i> Glomerular proximal...
Apoptosis contributes to the development of diabetic nephropathy (DN), but mechanisms that lead diabetes-induced cell death are not fully understood. Here, we combined a functional genomics screen for cDNAs induce apoptosis in vitro with transcriptional profiling renal biopsies from patients DN. Twelve 138 full-length induced human embryonic kidney cells matched upregulated mRNA transcripts tissue Confirmatory screens identified induction BASP1 tubular cross sections DN tissue. In vitro,...
Missense mutations in TP53 gene promote metastasis human tumours. However, little is known about the complete loss of function p53 tumour metastasis. Here we show that squamous cell carcinomas generated by specific ablation Trp53 mouse epidermis are highly metastatic. Biochemical and genome-wide mRNA miRNA analyses demonstrated metastases associated with early induction epithelial-mesenchymal transition (EMT) deregulated expression primary Increased miR-21 was observed undifferentiated,...
Abstract. Fas ligand (FasL) is a cell membrane cytokine that can promote apoptosis through activation of receptors. receptor induces glomerular in vivo and participates tubular death during acute renal failure. However, there little information on the expression FasL kidney. This study reports mRNA protein are present normal mouse rat In situ hybridization immunohistochemistry showed proximal epithelium main site addition, increased total kidney de novo by cells were observed two different...
Aberrant activation of the phosphoinositide-3-kinase (PI3K)/PTEN/Akt pathway, leading to increased proliferation and decreased apoptosis, has been implicated in several human pathologies including cancer. Our previous data have shown that Akt-mediated signaling is an essential mediator mouse skin carcinogenesis system during both tumor promotion progression stages. In addition, overexpression Akt also able transform keratinocytes through transcriptional posttranscriptional processes. Here,...
Abstract Purpose: Bladder cancer is a clinical and social problem due to its high incidence recurrence rates. It frequently appears in elderly patients showing other medical comorbidities that hamper the use of standard chemotherapy. We evaluated activity CDK4/6 inhibitor as new therapy for unfit cisplatin (CDDP). Experimental Design: cell lines were tested vitro sensitivity inhibition. A novel metastatic bladder mouse model was developed used test vivo activity. Results: Cell sensitive...
High-grade neuroendocrine lung malignancies (large-cell cell carcinoma, LCNEC, and small-cell SCLC) are among the most deadly cancer conditions with no optimal clinical management. The biological relationships between SCLC LCNEC still largely unknown a current matter of debate as growing molecular data reveal high heterogeneity potential therapeutic consequences. Here we describe murine models high-grade carcinomas generated by loss 4 tumor suppressors. In an Rbl1 -null background, deletion...
Abstract Squamous cell carcinomas (SCC) represent the most aggressive type of nonmelanoma skin cancer. Although little is known about causal alterations SCCs, in organ-transplanted patients E7 and E6 oncogenes human papillomavirus, targeting p53- pRb-dependent pathways, have been widely involved. Here, we report functional consequences simultaneous elimination Trp53 retinoblastoma (Rb) genes epidermis using Cre-loxP system. Loss p53, but not pRb, produces spontaneous tumor development,...
Observations in thyroid patients and experimental animals show that the skin is an important target for hormones. We previously showed deletion mice of hormone nuclear receptors TRα1 TRβ (the main hormone–binding isoforms) results impaired epidermal proliferation, hair growth, wound healing. Stem cells located at bulges follicles are responsible cycling contribute to regeneration new epidermis after wounding. Therefore a reduction number or function bulge stem could be this phenotype. Bulge...
Abstract Lung cancer, the leading cause of cancer mortality, exhibits diverse histologic subtypes and genetic complexities. Numerous preclinical mouse models have been developed to study lung but data from these are disparate, siloed, difficult compare in a centralized fashion. In this study, we established Cancer Autochthonous Model Gene Expression Database (LCAMGDB), an extensive repository 1,354 samples 77 transcriptomic datasets covering 974 genetically engineered (GEMM), 368...
Head and neck squamous cell carcinoma (HNSCC) is a common human neoplasia with poor prognosis survival that frequently displays Akt overactivation. Here we show mice displaying constitutive activity (myrAkt) in combination Trp53 loss stratified epithelia develop oral cavity tumors phenocopy HNSCC. The myrAkt lesions, making it possible model of dysplasia. malignant conversion these which hampered due to the induction premature senescence, achieved by subsequent ablation gene same cells vivo....
HMG-CoA reductase inhibitors reduce cardiovascular mortality, although the mechanisms of action have not been completely elucidated. The presence T cells and apoptotic in atherosclerotic plaques is well established, reduction cellular content being a marker their vulnerability. One main cell death activation Fas-Fas ligand (FasL) system.We studied whether can regulate FasL expression cytotoxicity human (Jurkat cells). Activation Jurkat with phorbol esters ionomycin increased expression, an...