A5057586035- Radiopharmaceutical Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Epigenetics and DNA Methylation
- Medical Imaging Techniques and Applications
- Cancer Research and Treatments
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Labor Law and Work Dynamics
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Peptidase Inhibition and Analysis
- Bladder and Urothelial Cancer Treatments
- Neuroendocrine Tumor Research Advances
- RNA modifications and cancer
- Human Rights and Immigration
- Tryptophan and brain disorders
- Colorectal Cancer Surgical Treatments
- Trace Elements in Health
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Colorectal Cancer Screening and Detection
- Neurotransmitter Receptor Influence on Behavior
- Comparative International Legal Studies
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas
2016-2025
Hospital Universitario Miguel Servet
2023
Hospital Clínico San Carlos
2023
Unidades Centrales Científico-Técnicas
2001-2022
Centre for Research and Technology Hellas
2020-2021
Universidad Complutense de Madrid
2007-2016
Hospital Vega Baja
2009-2015
Foundation for Transport and Energy Research and Development
2014
Centro de Investigación y Desarrollo
2014
Research Institute Hospital 12 de Octubre
2014
We demonstrate the pharmacologic potential of purified cell-penetrating Omomyc mini-protein to directly inhibit MYC function in vitro and vivo.
Abstract Odontogenic tumours are a heterogeneous group of lesions that develop in the oral cavity region and characterized by formation tumoural structures differentiate as teeth. Due to diversity their histopathological characteristics clinical behaviour, classification these is still under debate. Alterations morphogenesis pathways such Hedgehog, MAPK WNT/β-catenin implicated odontogenic lesions, but molecular bases many unknown. In this study, we used genetically modified mice study role...
Bladder cancer is a highly prevalent human disease in which retinoblastoma (Rb) pathway inactivation and epigenetic alterations are common events. However, the connection between these two processes still poorly understood. Here, we show that vivo of all Rb family genes mouse urothelium sufficient to initiate bladder development. The characterization tumors revealed multiple molecular features cancer, including activation E2F transcription factor subsequent Ezh2 expression several signaling...
There is a need to develop new and innovative polymer carriers be used as drug delivery systems and/or imaging agents owing the fact that there no universal polymeric system can in treatment of all diseases. Additionally, limitations with existing systems, such lack biodegradability biocompatibility, inevitably lead side effects poor patient compliance. New therapeutics based on amino acids are excellent candidates for delivery, they do not suffer from these limitations. This article reports...
Maternal exposure to infections during gestation has been shown predispose individuals neuropsychiatric disorders. Additionally, clinical data suggest that cannabis use may trigger the onset of schizophrenia in vulnerable individuals. However, direction causality remains unclear. To elucidate this issue, we utilized a rat model maternal immune activation combined with increasing doses Δ9-tetrahydrocannabinol adolescence both male and female rats. We investigated several behaviors adulthood...
High-grade neuroendocrine lung malignancies (large-cell cell carcinoma, LCNEC, and small-cell SCLC) are among the most deadly cancer conditions with no optimal clinical management. The biological relationships between SCLC LCNEC still largely unknown a current matter of debate as growing molecular data reveal high heterogeneity potential therapeutic consequences. Here we describe murine models high-grade carcinomas generated by loss 4 tumor suppressors. In an Rbl1 -null background, deletion...
The distribution of glucose and fatty-acid transporters in the heart is crucial for energy consecution myocardial function. In this sense, glucagon-like peptide-1 (GLP-1) enhancer, sitagliptin, improves homeostasis but it could also trigger direct cardioprotective actions, including regulation substrate utilization. Type-II diabetic GK (Goto-Kakizaki), sitagliptin-treated (10 mg/kg/day) wistar rats (n = 10, each) underwent echocardiographic evaluation, positron emission tomography scanning...
Background A critical challenge in the management of Glioblastoma Multiforme (GBM) tumors is accurate diagnosis and assessment tumor progression a noninvasive manner. We have identified Membrane-type 1 matrix metalloproteinase (MT1-MMP) as an attractive biomarker for GBM imaging since this protein actively involved growth progression, correlates with grade closely associated poor prognosis patients. Here, we report development immunoPET tracer effective detection MT1-MMP models. Methods An...
MYC's role in promoting tumorigenesis is beyond doubt, but its function the metastatic process still controversial. Omomyc a MYC dominant negative that has shown potent antitumor activity multiple cancer cell lines and mouse models, regardless of their tissue origin or driver mutations, by impacting on several hallmarks cancer. However, therapeutic efficacy against metastasis not been elucidated yet. Here we demonstrate for first time inhibition transgenic efficacious all breast molecular...
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of that lacks effective diagnostic and therapeutic options. Membrane type 1 matrix metalloproteinase (MT1-MMP) an attractive biomarker for improving patient selection. This study aimed to develop theranostic tool using tumour-selective anti-MT1-MMP antibody (LEM2/15) radiolabelled with
Purpose The goal of this study was to compare the tumor uptake kinetics and diagnostic value three 68Ga-DOTA-labeled somatostatin analogues (68Ga-DOTATOC, 68Ga-DOTANOC, 68Ga-DOTATATE) using PET/CT in a murine model with subcutaneous meningioma xenografts. Methods experiment performed 16 male NUDE NU/NU mice bearing xenografts human cell line (CH-157MN). 68Ga-DOTATOC, 68Ga-DOTATATE were produced FASTLab automated platform. Imaging on an Argus small-animal scanner. SUVmax liver muscle,...
Abstract Purpose: The induction of 4-1BB signaling by agonistic antibodies can drive the activation and proliferation effector T cells thereby enhance a T-cell–mediated antitumor response. Systemic administration anti-4-1BB–agonistic IgGs, although effective preclinically, has not advanced in clinical development due to their severe hepatotoxicity. Experimental Design: Here, we generated humanized EGFR-specific 4-1BB-agonistic trimerbody, which replaces IgG Fc region with human collagen...
Abstract Substance use disorders are more prevalent in schizophrenia, but the causal links between both conditions remain unclear. Maternal immune activation (MIA) is associated with schizophrenia which may be triggered by stressful experiences during adolescence. Therefore, we used a double-hit rat model, combining MIA and peripubertal stress (PUS), to study cocaine addiction underlying neurobehavioural alterations. We injected lipopolysaccharide or saline on gestational days 15 16...
Abstract Radionuclide generator systems can routinely provide radionuclides on demand such as 68 Ga produced by a Ge/ without the availability of an on-site accelerator or research reactor. Thus, in this work nano-SnO 2 was used to develop new which evaluated over period 17 months and 305 elution cycles. The yield 91.1 ± 1.8% first 7 mL (1 M HCl eluent) when then it decreased with time use 73.8 1.9%. Around 80% elutable activity obtained 1 Ge content eluate did not exceed × 10 –4 %...
Purpose. The Gram-positive Staphylococcus aureus bacterium is one of the leading causes infection in humans. lack specific noninvasive techniques for diagnosis staphylococcal together with severity its associated complications support need new and selective diagnostic tools. This work presents successful synthesis an immunotracer that targets α-toxin released by S. aureus. Methods. [89Zr]Zr-DFO-ToxAb was synthesized based on radiolabeling anti-α-toxin antibody zirconium-89. physicochemical...
LEAD-452 is a humanized bispecific EGFR-targeted 4-1BB-agonistic trimerbody with unique trimeric configuration compared to other 4-1BB-specific antibodies that are currently in development. Indeed, enhanced tumor-specific costimulation and very remarkable safety efficacy profiles have been observed mouse models. Here, we conducted for the first time preclinical pharmacokinetic toxicity study non-human primates (NHP) (Macaca fascicularis). exhibits comparable binding affinity human macaque...
We assessed the effectiveness of perioperative MAGIC-style chemotherapy in our series focused on tumor regression grade and survival rate.We conducted a retrospective study 53 patients following regimen epirubicin, cisplatin, fluorouracil or capecitabine (ECF/X). Forty-four (83 %) neoplasias were located stomach 9 (17 at esophagogastric junction. Perioperative completion, resection, TNM staging, (Becker's classification) analyzed.Forty-five (85 completed 3 preoperative cycles. R0 resection...
Monoclonal antibodies (mAbs) are currently used as therapeutic agents in different types of cancer. However, mAbs and antibody fragments developed so far show suboptimal properties terms circulation time tumor penetration/retention. Here, we report the radiolabeling, pharmacokinetic evaluation, determination targeting capacity previously validated anti-CEA MFE23-scFv-based N-terminal trimerbody (MFE23N-trimerbody), results compared to those obtained for monomeric MFE23-scFv. Dissection...
Abstract It is well settled that the amyloidogenic properties of plasma protein transporter transthyretin (TTR) can be modulated by compounds stabilize its native tetrameric conformation. TTR also present in cerebrospinal fluid where it bind to Aβ-peptides and prevent Aβ aggregation. We have previously shown treatment Alzheimer’s Disease (AD) model mice with iododiflunisal (IDIF), a tetramer stabilizing compound, prevents AD pathologies. This evidence positioned IDIF as new lead drug for AD....