A5003101143- Cancer Cells and Metastasis
- Cell Adhesion Molecules Research
- Immunodeficiency and Autoimmune Disorders
- Advanced Breast Cancer Therapies
- Oral and Maxillofacial Pathology
- Pluripotent Stem Cells Research
- Animal Genetics and Reproduction
- CRISPR and Genetic Engineering
- Pancreatic and Hepatic Oncology Research
- Bone Tumor Diagnosis and Treatments
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- dental development and anomalies
- Cancer Mechanisms and Therapy
- Virus-based gene therapy research
- Melanoma and MAPK Pathways
- T-cell and B-cell Immunology
- Fibroblast Growth Factor Research
- Blood disorders and treatments
- Cancer-related Molecular Pathways
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas
2016-2022
Research Institute Hospital 12 de Octubre
2019-2022
Centre for Biomedical Network Research on Rare Diseases
2016-2020
Hospital Universitario Fundación Jiménez Díaz
2016-2020
Universidad Autónoma de Madrid
2016-2020
Centro de Investigación Biomédica en Red
2020
Universidad de Alcalá
2019
Abstract Odontogenic tumours are a heterogeneous group of lesions that develop in the oral cavity region and characterized by formation tumoural structures differentiate as teeth. Due to diversity their histopathological characteristics clinical behaviour, classification these is still under debate. Alterations morphogenesis pathways such Hedgehog, MAPK WNT/β-catenin implicated odontogenic lesions, but molecular bases many unknown. In this study, we used genetically modified mice study role...
Leukocyte adhesion deficiency type I (LAD-I) is a primary immunodeficiency caused by mutations in the ITGB2 gene and characterized recurrent life-threatening bacterial infections. These lead to defective or absent expression of β2 integrins on leukocyte surface, compromising extravasation at sites infection. Three different lentiviral vectors (LVs) conferring ubiquitous preferential CD18 myeloid cells were constructed tested human mouse LAD-I cells. All three hCD18-LVs restored CD11a...
Knockout mice for human disease-causing genes provide valuable models in which new therapeutic approaches can be tested. Electroporation of genome editing tools into zygotes,
CD18 is the common beta subunit of β2 integrins, which are expressed on hematopoietic cells. integrins essential for cell adhesion and leukocyte trafficking. Here we have analyzed expression in different subsets human stem progenitor cells (HSPCs) from cord blood (CB), bone marrow (BM), mobilized peripheral (mPB) samples. CD34+ were classified into CD18high CD18low/neg, each these populations was HSPC markers, as well their clonogenity, quiescence state, repopulating ability immunodeficient...
ERAS is a relatively uncharacterized gene of the Ras superfamily. It expressed in ES cells and first stages embryonic development; later on, it silenced majority cell types tissues. Although there are several reports showing expression tumoral lines human tumor samples, unknown if deregulated enough to drive development. In this report, we have generated transgenic mice expressing myoepithelial basal mammary gland stratified epithelia. spite low level expression, these showed phenotypic...