A5078392742- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Platelet Disorders and Treatments
- Kruppel-like factors research
- Eosinophilic Disorders and Syndromes
- Acute Myeloid Leukemia Research
- Hemoglobinopathies and Related Disorders
- Abdominal Trauma and Injuries
- Chronic Lymphocytic Leukemia Research
- Renal Diseases and Glomerulopathies
- Appendicitis Diagnosis and Management
- Blood properties and coagulation
- Blood Coagulation and Thrombosis Mechanisms
- Systemic Lupus Erythematosus Research
- Multiple Myeloma Research and Treatments
- COVID-19 Clinical Research Studies
- Acute Lymphoblastic Leukemia research
- Erythrocyte Function and Pathophysiology
- Gallbladder and Bile Duct Disorders
- Venous Thromboembolism Diagnosis and Management
- Blood groups and transfusion
- Antiplatelet Therapy and Cardiovascular Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Pancreatic and Hepatic Oncology Research
- Cell Adhesion Molecules Research
University of Catania
2015-2024
Tecnologie Avanzate (Italy)
2023
Policlinico Universitario di Catania
2022-2023
University of New Haven
2022
Azienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele
2014-2021
American College of Surgeons
2018
Cluster in Biomedicine
2014
Fondazione Gimema Onlus
2008
University of Oklahoma
2005
Ferrarotto Hospital
1994-2001
Hydroxyurea (Hydroxycarbamide; HU) is commonly used for the long-term treatment of patients with Philadelphia-chromosome negative chronic myeloproliferative neoplasms (MPNs). It considered a first-choice agent these disorders as underlined by European Leukemia Net Consensus Conference [1], although it formally approved this indication in some countries only. The drug reportedly well tolerated large majority subjects, systemic and/or localized toxicities have been reported. criteria...
Abstract We retrospectively studied 181 patients with polycythaemia vera ( n =67), essential thrombocythaemia =67) or primary myelofibrosis =47), who presented a first episode of splanchnic vein thrombosis (SVT). Budd–Chiari syndrome (BCS) and portal were diagnosed in 31 (17.1%) 109 (60.3%) patients, respectively; isolated the mesenteric splenic veins was detected 18 23 cases, respectively. After this index event, followed for 735 patient years (pt-years) experienced recurrences...
BackgroundWhether phlebotomy alone can adequately maintain target hematocrit in patients with low-risk polycythemia vera (PV) remains elusive.MethodsIn a phase 2 open-label randomized trial, we compared ropeginterferon alfa-2b (ropeg; 100 μg every weeks) only regarding maintenance of median level (≤45%) over 12 months the absence progressive disease (primary end point). In follow-up, crossover to alternative treatment group was allowed if primary point not met.ResultsIn total, 127 were...
Autoimmune hemolytic anemia (AHA) is a frequent complication of chronic lymphocytic leukemia (CLL). Although the pathogenesis AHA still unknown, an imbalance normal residual T cells believed to play central role. Since fludarabine reported affect primarily lymphocytes, we conducted retrospective study evaluate incidence and outcome in 112 CLL patients treated with alone. Eight had before therapy; only one achieved remission both after In other seven patients, observed no effect or even...
Coronavirus 2 (CoV-2) infection or coronavirus disease 2019 (COVID-19) is frequently associated with microvascular thrombosis.The microthrombosis in COVID-19 the result of interplay between inflammation and endotheliopathy. Elevated interleukin-6 (IL-6) characterizes resulting endotheliopathy coagulopathy marked by elevated D-dimer (DD). Aim this study to identify describe coagulation changes 100 moderate patients having lung involvement determine association severity prognosis....
This study compared two schedules of low-dose gemtuzumab ozogamicin (GO) as induction monotherapy for untreated acute myeloid leukaemia in older patients unfit intensive chemotherapy, to identify the more promising regimen further study. Patients were randomized receive either best supportive care or a course GO according one schedules: 3 mg/m(2) on days 1, and 5 (arm A), 6 day 1 8 B). Primary endpoint was rate disease non-progression (DnP), defined proportion achieving response maintaining...
To investigate the characteristics and clinical course of cerebral vein thrombosis (CVT) in patients with myeloproliferative neoplasms (MPN) we compared 48 MPN CVT (group MPN‐CVT) to 87 other venous MPN‐VT) 178 no MPN‐NoT) matched by sex, age at diagnosis (±5 years) type MPN. The study population was identified among 5,500 MPN, from January 1982 June 2013. Thrombophilia abnormalities were significantly more prevalent MPN‐CVT MPN‐VT than MPN‐NoT group ( P = 0.015), as well JAK2 V617F mutation...
Abstract We analyzed 597 patients with myeloproliferative neoplasms (MPN) who presented transient ischemic attacks (TIA, n = 270) or stroke (IS, 327). Treatment included aspirin, oral anticoagulants, and cytoreductive drugs. The composite incidence of recurrent TIA IS, acute myocardial infarction (AMI), cardiovascular (CV) death was 4.21 19.2%, respectively at one five years after the index event, an estimate unexpectedly lower than reported in general population. Patients tended to...
Introduction: Portal vein thrombosis (PVT) could be a life-threatening complication after splenectomy if not diagnosed promptly and treated properly. Risk factors of PVT are completely clarified. Spleen size underlying hematologic diseases main potential risk for this complication. Laparoscopic surgery might increase the developing PVT, as it reduces blood flow in portal system due to pneumoperitoneum but, on other hand, seems associated with less postoperative modifications coagulation...
Only a few studies have addressed long-term results comparing laparoscopic and open splenectomy in idiopathic thrombocytopenic purpura (ITP). We analyzed the 1-year age, sex, length of preoperative steroid therapy, diagnosis-to-splenectomy interval, platelet count relation to postoperative response after splenectomy.Data collected from two groups, treated by splenectomy, respectively, 20 patients each were retrospectively reviewed. Positive splenectomies, evaluated according International...
Background and Objectives:The aim of this study was to evaluate the results laparoscopic surgery performed for coexisting spleen gallbladder surgical diseases.Methods:Between May 2004 October 2012, 12 patients underwent concomitant splenectomy cholecystectomy. Indications included idiopathic thrombocytopenic purpura in 5 patients, hereditary spherocytosis 4 thalassemia intermedia 3 patients.Results:The mean operative time 100 minutes (range, 80–160 minutes), blood loss ranged from 0 150 mL...
We performed a retrospective study on patients with idiopathic thrombocytopenic purpura (ITP) to evaluate the response splenectomy in relation preoperative platelet count.Two groups of operated laparoscopic or open for ITP, count ≤30,000/μL (study group: 22 patients) and >30,000/μL (control 18 patients), respectively, were compared. The two homogeneous age, sex, length steroid therapy, time interval between diagnosis surgery (Student t test P > .1). results evaluated at one year after...
Peripheral blood T-lymphocyte subsets, evaluated by means of a series monoclonal antibodies, were assessed in 14 patients affected thalassaemia intermedia, 7 them previously splenectomized. A significant reduction T+4 cells ('helper' T cells) was found almost all patients, whereas T+8 ('suppressor/cytotoxic') showed marked increase only splenectomized subjects. Together with these quantitative T-subset abnormalities, which seemed to be partly either splenectomy or high serum iron levels, an...
Polycythemia vera (PV) causes thrombosis. Erythrocytosis and cell adhesiveness are responsible for JAK2V617F inflammation autoimmunity; however, whether or not autoimmunity thrombosis has yet to be proven. In 60 PV patients, we analyzed JAK2V671F its allele burden, autoimmune Th17 cells, interleukin-17 (IL-17), anti-endothelial antibodies (AECAs), endothelial leukocyte adhesion molecule-1 (ELAM-1), intercellular (ICAM-1), von Willebrand factor antigen (VWF: Ag). Fifty blood donors were used...
Intestinal hematoma is usually observed after an abdominal trauma or in patients treated with anticoagulant therapy. Conversely, idiopathic bowel very rare, being colon involvement sporadic few reports the Literature.The Authors report a case of spontaneous large hematoma. A 48-year-old man was admitted for thoraco-abdominal pain and signs acute abdomen fever. After ruling out heart diseases, CT scan revealed marked thickening ascending wall, obstructing lumen. Leukocytosis observed. In...