A5033613825- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Multiple Myeloma Research and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Kruppel-like factors research
- Viral-associated cancers and disorders
- Hemoglobinopathies and Related Disorders
- Peptidase Inhibition and Analysis
- Eosinophilic Disorders and Syndromes
- T-cell and Retrovirus Studies
- Hematological disorders and diagnostics
- Histone Deacetylase Inhibitors Research
- Hematopoietic Stem Cell Transplantation
- Blood properties and coagulation
- Neuroblastoma Research and Treatments
- Lung Cancer Treatments and Mutations
- Hepatitis B Virus Studies
- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- Erythrocyte Function and Pathophysiology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Centro di Riferimento Oncologico
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2024
Italian Foundation of Myelodysplastic Syndromes
2024
National Cancer Institute
2015-2017
University of Naples Federico II
2003-2013
Federico II University Hospital
2002-2011
Ceinge Biotecnologie Avanzate (Italy)
2004-2008
In this work, the effects of thalassemia, a blood disease quite diffuse in Mediterranean sea region, have been investigated at single cell level using Raman Tweezers system.By resonant excitation hemoglobin bands, we examined oxygenation capability β -thalassemic erythrocytes.A reduction fundamental erythrocyte function has found.The measurements performed on significant number red cells; relative statistical analysis is presented.Moreover, response to photo-induced oxidative stress diseased...
Abstract The standard treatment for young patients with untreated PTCLs is based on anthracycline containing-regimens followed by high-dose-chemotherapy and stem-cell-transplantation (HDT + SCT), but only 40% of them can be cured. Romidepsin, a histone-deacetylase inhibitor, showed promising activity in relapsed PTCLs; first line, Romidepsin was added CHOP. We designed study combining romidepsin CHOEP as induction before HDT auto-SCT (PTCL-NOS, AITL/THF, ALK-ALCL), aged 18–65 years. A phase...
Pregnancy is a high-risk event in women with essential thrombocythemia (ET). This observational study evaluated pregnancy outcome ET patients focusing on the potential impact of aspirin (ASA) or interferon alpha (IFN) treatment during pregnancy. We retrospectively analyzed 122 pregnancies 92 consecutively observed last 10 years 17 centers Italian registry (RIT). The live birth rate was 75.4% (92/122 pregnancies). risk spontaneous abortion 2.5-fold higher than control population (P < 0.01)....
We conducted a phase II study to assess activity and safety profile of bendamustine rituximab in elderly patients with untreated diffuse large B-cell lymphoma (DLBCL) who were prospectively defined as frail using simplified version the Comprehensive Geriatric Assessment (CGA). Patients had be over 70 years age, histologically confirmed DLBCL. Frail those younger than 80 at CGA or older an unfit profile. Treatment consisted 4-6 courses [90 mg/m2 days (d)1-2] (375 d1) administered every 28...
ABSTRACT Previous reports have indicated that during the era of combination antiretroviral therapy, major causes morbidity and mortality in people living with HIV (PLWH) were not solely linked to HIV‐related opportunistic infections but also cancers difficult manage due immunodeficiency. We investigated whether PLWH who underwent autologous hematopoietic stem cell transplantation (ASCT) for lymphomas experienced significant over past thirty years following infection. conducted a...
The sensitivity of lymph node excisional biopsy requires validation. Power Doppler ultrasound (US) helps predict the malignant status lymphadenopathies. We used power US to select for most suspected malignancy.One hundred fifty-two patients having lymphadenopathies with clinical suspicion lymphoma were divided into two well-matched groups and randomly assigned undergo either standard or US-directed biopsy.Histology showed a malignancy in 64% group (lymphoma, 49 patients; carcinoma, patients)...
We recently published a study aiming to verify the frequency of amyloid deposits in bone marrow patients with multiple myeloma (MM) who did not present any signs or symptoms systemic amyloidosis, applying Congo red technique on smears obtained by aspiration from posterior iliac spine. The results suggested that nearly 40% affected MM may have their marrow. Subsequently, this finding has been confirmed another performed histological specimens similar clinical setting. To explain discrepancy,...
The motor features of people with cerebellar ataxia suggest that locomotion is substantially impaired due to incoordination the head, trunk, and limbs. purpose this study was investigate how well a wearable soft passive exoskeleton worked for coordination in these patients. We used an optoelectronic system examine gait nine ataxic three different conditions: without two variants exoskeleton, one less other more flexible. investigated kinematics using trunk ranges motion, displacement center...
Myelodysplastic syndrome patients are subjects of advanced age, vulnerable and frail, whose outcome is heavily influenced by pre-existing comorbidities worsening the hematologic condition. Infections a rather common cause death (around 30%), especially, but not only, for IPSS-R higher risk patients.1-3 In MDS there significant impairment lymphopoiesis, resulting in lymphopenia (ALC < 1.0 × 109/l) around 38% poor prognosis.4 Data on innate adoptive immune systems (either disease related or...
Multiple myeloma (MM) is an aggressive malignancy that shapes, during its progression, a pro-tumor microenvironment characterized by altered protein secretion and the gene expression of mesenchymal stem cells (MSCs). In turn, MSCs from MM patients can exert high activity play strong immunosuppressive role. Here, we show, for first time, greater cell mobility paralleled activation FilaminA (FLNA) in MM-derived MSCs, when compared to healthy donor (HD)-derived MSCs. Moreover, suggest possible...
<title>Abstract</title> Lenalidomide (LEN) can induce RBC transfusion independence (RBC-TI) in 60–70% of del(5q) myelodysplastic syndrome (MDS) patients. Current recommendation is to continue LEN responding patients until failure or progression, with likelihood toxicity and a high cost for healthcare systems. This HARMONY Alliance study investigated the outcome MDS who discontinued RBC-TI. We enrolled 118 an IPSS-R low-intermediate risk. Seventy (59%) intolerance, 38 (32%) per their...
Multiple myeloma (MM) patients complain of pain and stiffness limiting motility. To determine if can benefit from vertebroplasty, we assessed muscle activation co-activation before after surgery. Five with MM five healthy controls performed sitting-to-standing lifting tasks. Patients the task one month Surface electromyography (sEMG) was recorded bilaterally over erector spinae longissimus rectus abdominis superior muscles to evaluate trunk their mean, maximum, full width at half maximum...