A5001854188- Hepatitis C virus research
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Hemophilia Treatment and Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Platelet Disorders and Treatments
- Hematological disorders and diagnostics
- Hemoglobinopathies and Related Disorders
- T-cell and B-cell Immunology
- Digital Imaging for Blood Diseases
- Iron Metabolism and Disorders
- Research in Social Sciences
- Polyomavirus and related diseases
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Systemic Lupus Erythematosus Research
- Cancer Genomics and Diagnostics
- Hepatitis Viruses Studies and Epidemiology
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Clostridium difficile and Clostridium perfringens research
Helsinki University Hospital
2016-2025
Helsinki Art Museum
2019
Finnish Red Cross
1994-2015
University of Helsinki
2013
University of Rostock
2010
The Kavli Trust
1994
PURPOSE Clinical relapse is the major threat for patients with myelodysplastic syndrome (MDS) undergoing hematopoietic stem-cell transplantation (HSCT). Early detection of measurable residual disease (MRD) would enable preemptive treatment and potentially reduced risk. METHODS Patients MDS planned HSCT were enrolled in a prospective, observational study evaluating association between MRD clinical outcome. We collected bone marrow (BM) peripheral blood samples until relapse, death, or end 24...
Abstract The prevalence and functional impact of somatic mutations in nonleukemic T cells is not well characterized, although clonal T-cell expansions are common. In immune-mediated aplastic anemia (AA), cytotoxic shown to participate disease pathogenesis. We investigated the mutation profiles AA by a custom panel 2533 genes. sequenced CD4+ CD8+ 24 patients compared results 20 healthy controls whole-exome sequencing 37 with AA. Somatic variants were common both but enriched patients’ cells,...
In myelodysplastic syndrome (MDS) and myeloproliferative neoplasm (MPN), bone marrow (BM) histopathology is assessed to identify dysplastic cellular morphology, cellularity, blast excess. Yet, other morphologic findings may elude the human eye. We used convolutional neural networks extract features from 236 MDS, 87 MDS/MPN, 11 control BM biopsies. These predicted genetic cytogenetic aberrations, prognosis, age, gender in multivariate regression models. Highest prediction accuracy was found...
Hydroxyl radical formation catalysed by non-transferrin-bound iron (NTBI) might contribute to transplantation-related complications. The occurrence of NTBI in 10 adult allogeneic stem cell transplantation (SCT) patients was followed for 20 d. transferrin saturation reached 99% on d -4 and remained > 80% thereafter. NTBI, measured as bleomycin-detectable iron, detected 6-18 all with a peak -4. High levels were associated the appearance threshold at saturation. Prevention potential deleterious...
In myelodysplastic syndromes (MDS), cytogenetic characteristics of the malignant bone marrow cells influence clinical course. The aim this study was to evaluate whether cytogenetics is useful predict outcome and response in patients with del(5q) under azacitidine (AZA) ± lenalidomide (LEN) therapy. We therefore performed comprehensive analyses MDS treated within randomized phase II trial NMDSG10B. Seventy-two were enrolled 46 (64%) had sufficient at inclusion evaluation. Karyotyping...
Immune aplastic anemia (AA) is a life-threatening bone marrow failure disorder driven by an autoimmune T cell attack against hematopoietic stem and progenitor cells (HSPCs). However, the exact autoantigen targets role of other immune in pathogenesis AA are unknown. Here, we analyzed cohort 218 patients with using single-cell RNA receptor (TCR) αβ sequencing, TCRβ flow cytometry, plasma cytokine profiling. We identified natural killer (NK) CD8 + terminally differentiated effector (T EMRA )...
We investigated the effect of free, non-transferrin-bound iron occurring in haematological stem cell transplant patients on growth Staphylococcus epidermidis serum vitro, and prevention bacterial by exogenous apotransferrin. S. did not grow normal at inoculated densities up to 10(3) cfu ml(-1) but slow could be detected higher initial inocula. Addition free abolished growth-inhibitory serum, whereas addition apotransferrin again restored it. Appearance loss inhibition coincided patient...
Free iron induced hydroxyl radical formation is one possible mechanism for tissue injury during cytotoxic therapy. We studied the appearance of free, non-transferrin-bound (NTBI) at baseline and 20-d period after onset chemotherapy in patients with haematological malignancy undergoing intensive or conditioning autologous stem cell transplantation (aSCT). NTBI was detected on average 15.6 d treated only, 6.1 aSCT. The recovery bone marrow function coincided disappearance NTBI. type regimen...
Abstract We closely observed 86 transfusions to multitransfused hematologic patients with leukocyte‐depleted platelet concentrates (PCs) prepared from buffy coats (BC PCs), filtered either prior storage (BC1) or after 3–4 days' (BC3). The were first given, randomly, BC1 BC3, and thereafter used as their own controls by giving them the two BC types alternately. results compared an earlier study on standard platelet‐rich plasma (PRP) PCs (46 23 patients) PRP (23 12 patients). There was no...
Summary. Myeloablative treatment results in iron accumulation and the appearance of non‐transferrin‐bound (NTBI) circulation, which may contribute to treatment‐related organ damage susceptibility infections. The aim this study was investigate efficacy human apotransferrin binding NTBI patients receiving an allogeneic stem cell transplant after myeloablative conditioning. A single intravenous 100 mg/kg dose given six adult on d 3 transplantation. Initially, all had serum transferrin...
Myeloablative conditioning prior to allogeneic stem cell transplantation causes a rapid increase in transferrin saturation and potentially toxic non-transferrin-bound iron (NTBI) plasma. We have studied the ability of repeatedly administered apotransferrin maintain this transferrin-bound form. Twenty adult patients undergoing myeloablative were enrolled receive with one three dosage regimens. Ten consecutive same preconditioning as controls. At highest dose level, full appearance NTBI...
Various gastrointestinal infiltrations have been described in patients with chronic lymphocytic leukaemia (CLL). Here, we report a 69-year-old man CLL and anaemia whom the macroscopic finding of colonoscopy was normal, but histological specimens revealed leukemia ileum colon. If patient has any symptoms suggesting possible GI manifestation haematologic disease or not explained by bone marrow infiltration hemolysis, diagnostic evaluation should include endoscopies adequate biopsies.
Abstract Background Bone marrow aspiration and/or biopsy ( BMAB ) is often an unpleasant and painful procedure in spite of local anaesthetic infiltration. This randomized placebo‐controlled trial compared the pain relieving effect sublingual fentanyl placebo during . Methods One hundred sixty patients were to receive either 200 μg, 100 μg (patients ≥ 70 years old, weight ≤ 50 kg or poor health) before The grade anxiety infiltration, aspiration, immediately after assessed using N umeral R...
Because of the suboptimal efficacy, cost, and adverse effects interferon in chronic hepatitis C (HCV), predictors have been sought to detect patients with a good treatment response. Also, markers for determining poor response early course therapy, such as lack viral clearance, proposed.Ninety-seven were enrolled receive leukocyte alpha-interferon according stepped-care management protocol. The final virological was evaluated 74 after 6-month post-treatment follow-up. relationship between...