A5101586723- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Orthopaedic implants and arthroplasty
- Renal and related cancers
- Insect and Pesticide Research
- Total Knee Arthroplasty Outcomes
- Colorectal and Anal Carcinomas
- Peptidase Inhibition and Analysis
- Lung Cancer Treatments and Mutations
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Diagnosis and Treatment
- Insect and Arachnid Ecology and Behavior
- Neuroendocrine Tumor Research Advances
- Genetic factors in colorectal cancer
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Diagnosis and Treatment
University of Parma
2015-2024
Ospedale di Parma
2009-2023
Ospedale Maggiore
2021
Ospedale Cannizzaro
2008-2017
Azienda Sanitaria Locale Alessandria
2017
Ospedale SS. Annunziata
2015-2016
Maria Cecilia Hospital
2015
Università Campus Bio-Medico
2007-2012
University of Catania
2009
University of Modena and Reggio Emilia
2008
Trastuzumab has recently shown efficacy in the treatment of HER2-positive advanced gastric adenocarcinoma. Although antibody-based therapies target metastatic disease, HER2 status is usually evaluated primary tumour because sites are rarely biopsied. The aim this study was to compare and paired assessed by fluorescence situ hybridisation (FISH) immunohistochemistry (IHC) 72 secondary lesions adenocarcinoma corresponding tumours. Concordance FISH results, evaluable 68 matched sites, 98.5%....
Abstract The standard treatment for young patients with untreated PTCLs is based on anthracycline containing-regimens followed by high-dose-chemotherapy and stem-cell-transplantation (HDT + SCT), but only 40% of them can be cured. Romidepsin, a histone-deacetylase inhibitor, showed promising activity in relapsed PTCLs; first line, Romidepsin was added CHOP. We designed study combining romidepsin CHOEP as induction before HDT auto-SCT (PTCL-NOS, AITL/THF, ALK-ALCL), aged 18–65 years. A phase...
Purpose The direct anterior approach (DAA) for total hip arthroplasty (THA) is claimed to be as effective but less invasive than the conventional posterior (PA). However, higher risk of femoral fracture and soft tissue damage cannot underestimated. present authors believe that difficult exposure surgeon's knowledge possible complications related preparation may result in a rate undersized stems when compared PA, even short component employed minimise these risks. Methods A retrospective...
Aim: Considering the unmet need for counseling of cancer patients treated with immune checkpoint inhibitors (CKI) about influenza vaccination, an explorative study was planned to assess flu vaccine efficacy in this population. Methods: INVIDIa a retrospective, multicenter study, enrolling consecutive advanced outpatients receiving CKI during season 2016–2017. Results: Of 300 patients, 79 received vaccine. The incidence syndrome 24.1% among vaccinated, versus 11.8% controls; odds ratio: 2.4;...
Aim: This prospective study aimed to envisage the putative prognostic significance of clinical and hematologic parameters in advanced non-small-cell lung cancer patients treated with nivolumab. Materials & methods: Correlations several disease control survival outcomes were provided. Results: A total 54 included. An ECOG performance status 0–1, lack liver bone metastases a timeframe from last systemic treatment ≥4 months correlated better control. The same was observed for baseline low...
Abstract Background Type 2 diabetes mellitus (T2DM) is associated with increased risk of colon cancer (CC), whereas metformin use seems to be protective. However, the impact on death or disease recurrence after radical surgery for CC remains uncertain. Materials and Methods This a substudy conducted in patients high-risk stage II III randomized TOSCA trial, which compared 3 versus 6 months fluoropyrimidine-oxaliplatin adjuvant chemotherapy. Objective study was investigate exposure during...
Background Until now, no robust data supported the efficacy, safety and recommendation for influenza vaccination in patients with cancer receiving immune checkpoint inhibitors (ICIs). Methods The prospective multicenter observational INfluenza Vaccine Indication During therapy Immune (INVIDIa-2) study investigated clinical effectiveness of advanced ICIs, enrolled 82 Italian centers from October 2019 to January 2020. primary endpoint was time-adjusted incidence influenza-like illness (ILI)...
Human nutrition is a broad, interdisciplinary cultural and scientific field, involving wide range of chemical, molecular, genetic, biochemical, physiological, psychological, cognitive-behavioral, statistical-epidemiological, clinical, technological, educational, economic, political social aspects. The high levels over- under-nutrition represent an important risk factor for mortality burden disease worldwide. It the opinion Federation Italian Nutrition Societies (FeSIN) that these two sides...
Pancreatic ductal adenocarcinoma is one of the most lethal solid malignancies, characterized by its aggressiveness and metastatic potential, with a 5-year survival rate only 13%. Progress in management disease has been modest. A robust connection between nervous system tumor progression exists, prominent neural alterations having observed during pancreatic cancer's progression, including hypertrophy, density, remodeling. The microenvironment includes s set cells structures that constantly...
The value of HER-2/neu status as a predictor response to anthracycline-based chemotherapy is still matter debate. We evaluated the contribution gene amplification and other biologic markers in predicting different doses neoadjuvant chemotherapy.Clinical pathologic records 115 primary breast cancer patients were reviewed. Forty-eight 67 received high (doxorubicin > or =20 mg/m2/wk; epirubicin =30 mg/m2/wk) moderate-low anthracycline dose intensity regimens, respectively. Pathologic diagnosis,...
Abstract The purpose of the present study was to validate new GRade, Age, Nodes and Tumor (GRANT) score for renal cell carcinoma (RCC) prognostication within a large population patients. Within Surveillance, Epidemiology, End Results database, we identified patients with either clear-cell or papillary RCC, who underwent nephrectomy between 2001 2015. Harrell’s C-Index, calibration plot decision curve analysis were used GRANT model using five-risk group stratification (0 vs. 1 2 3 4 risk...
Metastatic intrahepatic cholangiocarcinoma still has a dismal prognosis. The aim of our study was to investigate the prognostic role bone metastases in patients affected by cholangiocarcinoma.A total 186 metastatic were retrospectively reviewed. Clinicopathologic and survival data collected reviewed, particular overall survival, progression-free after first-line treatment time from end therapy cancer death.Around 11% developed metastases. This subgroup showed no differences chemotherapy but...
Pulmonary metastasectomy is considered a standard procedure in the treatment of metastatic colorectal cancer (CRC). Different prognostic factors including multiple nodules, presence extra-pulmonary metastases and BRAF mutation status have been associated with poor survival. The aim this study was to evaluate which influenced survival CRC patients undergoing pulmonary by studying primary tumors metastases.All treated for who presented 10-year period were (group A). A control group did not...
Aim: The knowledge of the immune context renal cell carcinoma (RCC) is useful to predict benefit from immunotherapy. We retrospectively characterized RCC patients underwent primary nephrectomy and pulmonary metastasectomy. Materials & methods: Intratumoral infiltrating lymphocytes peritumoral lymphocytes, lymphocyte subpopulations (CD4+, CD8+), PD-1, PD-L1 were explored in paired samples (T) respective metastases (M). Results: variables demonstrated intralesional intratumoral heterogeneity....