A5088020586- Hereditary Neurological Disorders
- Eicosanoids and Hypertension Pharmacology
- Pancreatic function and diabetes
- Signaling Pathways in Disease
- Curcumin's Biomedical Applications
- Metabolism, Diabetes, and Cancer
- Adenosine and Purinergic Signaling
- Cellular Mechanics and Interactions
- Dietary Effects on Health
- Diet and metabolism studies
- Immune cells in cancer
- Natural Antidiabetic Agents Studies
- Diabetes and associated disorders
- Alcohol Consumption and Health Effects
- Pharmacology and Obesity Treatment
- Nerve injury and regeneration
- Healthcare and Venom Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Nitric Oxide and Endothelin Effects
- Neurological diseases and metabolism
Université de Limoges
2022-2024
American University of Beirut
2019-2022
American University of Beirut Medical Center
2022
University of Pittsburgh
2021
Délégation Paris 5
2019
Inserm
2019
Université Paris Cité
2019
In an aging population, intense interest has shifted toward prolonging health span. Mounting evidence suggests that cellular reactive species are propagators of cell damage, inflammation, and senescence. Thus, such have emerged as putative provocateurs targets for senolysis, a clearer understanding their molecular origin regulation is paramount importance. inquiry into signaling triggered by proxy instigator, hyperglycemia, we show NADPH Oxidase (NOX) drives DNA damage alters nuclear...
Diabetes triggers peripheral nerve alterations at a structural and functional level, collectively referred to as diabetic neuropathy (DPN). This work highlights the role of liver X receptor (LXR) signaling pathway cross talk with reactive oxygen species (ROS)–producing enzyme NADPH oxidase-4 (Nox4) in pathogenesis DPN. Using type 1 (T1DM) mouse models together cultured Schwann cells (SCs) skin biopsies from patients 2 diabetes (T2DM), we revealed implication LXR Nox4 pathophysiology T1DM...
Curcumin has been shown to exert beneficial effects in peripheral neuropathies. Despite its known biological activities, curcumin unfavorable pharmacokinetics. Its instability linked failure clinical trials of for the treatment human pathologies. For this reason, we developed curcumin-loaded cyclodextrin/cellulose nanocrystals (NanoCur) improve The present study aims assess potency a low dose NanoCur 2 Charcot-Marie-Tooth disease type 1A (CMT1A) rodent models at different stages disease....
Peripheral neuropathy (PN) is correlated with obesity and metabolic syndrome. Intermittent fasting (IF) has been described as the cornerstone in management of obesity; however, its role prediabetic complications not well elucidated. Cytochromes P450 Monooxygenases (CYP450) are major sources Reactive Oxygen Species (ROS) that orchestrate onset development diabetic complications. One CYP-metabolites, Expoxyecosatetraenoic Acids (EETs), considered to be negative regulators ROS production. In...
The sensorimotor and histological aspects of peripheral neuropathies were already studied by our team in two rat models: the sciatic nerve crush Charcot-Marie-Tooth-1A disease. In this study, we sought to highlight compare protein signature these pathological situations. Indeed, identification profiles diseases can play an important role development pharmacological targets. fact, rats develop motor impairments that are more severe hind limbs. Therefore, for first time, expression was...
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Abstract Curcumin was shown to exert beneficial effects on nerve function in peripheral neuropathies. Despite its prominent biological activities, curcumin presents with unfavorable pharmacokinetics. For this purpose, we have developed curcumin-loaded cyclodextrin/cellulose nanocrystals (NanoCur) bypass limitation. The current study aims assess the potency of NanoCur Charcot-Marie-Tooth disease type 1A (CMT1A) rodent models and compare efficacy Theracurmin® (Thera), a commercially available...