A5078073567- Cardiovascular Function and Risk Factors
- Retinal Diseases and Treatments
- Diet and metabolism studies
- Connexins and lens biology
- Retinal and Optic Conditions
- Effects and risks of endocrine disrupting chemicals
- Primate Behavior and Ecology
- Retinal Development and Disorders
- Saffron Plant Research Studies
- Antioxidant Activity and Oxidative Stress
- Toxic Organic Pollutants Impact
- Immunodeficiency and Autoimmune Disorders
- Bee Products Chemical Analysis
- Cardiac Imaging and Diagnostics
- Advanced Glycation End Products research
- Veterinary Pharmacology and Anesthesia
- Advancements in Transdermal Drug Delivery
- Plant Gene Expression Analysis
- Prenatal Substance Exposure Effects
- Genomics, phytochemicals, and oxidative stress
- Atherosclerosis and Cardiovascular Diseases
- Phosphodiesterase function and regulation
- Stress Responses and Cortisol
- Cardiovascular and exercise physiology
- Ferroptosis and cancer prognosis
Gifu Pharmaceutical University
2018-2025
Shin Nippon Biomedical Laboratories (Japan)
2005-2025
Shin Nippon Biomedical Laboratories (United States)
2010-2022
Daiichi-Sankyo (Japan)
2019
Osaka Prefecture University
1995
Abstract BACKGROUND: Ustekinumab is a human monoclonal antibody that binds to the p40 subunit of interleukin (IL) 12 and IL‐23 inhibits their pharmacological activity. To evaluate potential effects ustekinumab treatment during pregnancy, developmental studies were conducted in cynomolgus macaques. METHODS: was tested two embryo/fetal development (EFD) combined EFD/pre postnatal (PPND) study. In EFD studies, pregnant macaques (12/group) dosed with saline or (9 mg/kg IV, 22.5 SC, 45 IV SC...
Cynomolgus monkeys ( Macaca fascicularis ) are vital in biomedical research, particularly for drug development and studying neurological diseases. However, accurately identifying individuals group housing environments remains a significant challenge. This paper presents near real-time facial recognition system tailored cynomolgus monkeys, utilizing fine-tuned Detectron2 model face detection, followed by eigenface-based classification with Support Vector Machine (SVM) radial basis function...
Abstract Background Blue light exposure is known to induce reactive oxygen species (ROS) production and increased endoplasmic reticulum stress, leading apoptosis of photoreceptors. Maqui berry ( Aristotelia chilensis ) a fruit enriched in anthocyanins, for beneficial biological activities such as antioxidation. In this study, we investigated the effects extract (MBE) its constituents on subcellular damage induced by blue irradiation mouse retina-derived 661W cells. Methods We evaluated MBE...
Abstract The cornea is directly exposed to cigarette smoke, and smoking a risk factor for several corneal diseases including dry eye syndrome. Currently, heated tobacco products (HTPs) are widely used as substitutes around the world. In present study, we investigated molecular mechanism(s) leading cellular injury induced by smoke extract (CSE) or HTPs. Exposure CSE perturbed formation of tight junctions, an increase in cell volume, decrease transepithelial electrical resistance (TER) human...
Ocular angiogenesis, including retinopathy of prematurity, diabetic retinopathy, and exudative age-related macular degeneration, are closely related to oxidative stress. Many reports have shown that the cellular protective mechanism against stress inflammatory response has nuclear factor-erythroid 2-related factor-2 (Nrf2) activity. The aim this study was investigate effectiveness Nrf2 activation in treating ocular diseases with abnormal vessels.The effects activators, bardoxolone methyl...
The corneal epithelium is located at the outermost layer of ocular surface and continuously exposed to environmental factors, such as ultraviolet (UV) radiation from sunlight. UV irradiation causes excessive production reactive oxygen species (ROS) in cells, which results oxidative damage membrane-bound organelles mitochondria, eventually leading cell death. Crocetin, a natural carotenoid found plants, has various biological properties including antioxidant activity. In this study, we...
The purpose of this study was to investigate the feasibility evaluating cardiac function by real time three-dimensional (RT3D) echocardiography in isoflurane-anesthetized male cynomolgus monkeys. Additionally differences between inhibitory effects beta-blockers and a Ca channel blocker on left ventricular (LV) were examined.End-diastolic volume (EDV), end-systolic (ESV) ejection fraction (EF) control (without any drug effect) not significantly changed repetitive measurement at 30-day...
Objective: This study was conducted to evaluate the effects of anti-vascular endothelial growth factor (VEGF) antibody (bevacizumab) on vascular leakage and fibrosis in a monkey choroidal neovascularization (CNV) model. The relationship between fibrotic tissue subretinal hyper-reflective material (SHRM), optical coherence tomography (OCT) images, also investigated. Methods: Experimental CNV induced male cynomolgus monkeys by laser photocoagulation. Intravitreal injection bevacizumab at 0.5...
The corneal epithelium is continuously exposed to oxygen, light, and environmental substances. Excessive exposure those stresses thought be a risk factor for eye diseases. Photokeratitis damage the resulting in painful condition caused by unprotected UV rays, usually from sunlight, often found people who spend long time outdoors. In modern life, human eyes are artificial light light-emitting diode (LED) displays of computers smartphones, it has been shown that short-wavelength (blue) LED can...
Objective: A retinal vein occlusion (RVO) is a relatively common vascular disorder, especially in the elderly. Many experiments have been performed on patients with an RVO but performing any type of and longitudinal humans difficult, if not impossible, ethical grounds. Therefore, we created model by laser irradiation cynomolgus monkeys after intravenous injection rose bengal. We evaluated pathological changes retina, effects ranibizumab, anti-vascular endothelial growth factor (VEGF)...
1. In the cynomolgus macaque, UDP-glucuronosyltransferases (UGTs) 1As have similar molecular and enzymatic characteristics to those of their human orthologs. However, genetic polymorphisms in major UGT1A1/6/9 not been investigated.2. We re-sequenced UGT1A1, UGT1A6, UGT1A9 186 macaques (bred Cambodia, China, or Indonesia) 54 rhesus found 15, 13, 26 non-synonymous variants, respectively.3. Of these respectively, 10, 9, 12 were unique macaques; 4, 1, 2 2, 5 both macaques. The frequency UGT1A1...
Effects of repeated s.c. treatments with 50 mumol (approx. 31 mg)/kg/day neomycin for 10 or 15 days were examined in mice. There no significant differences between saline and treatment groups the motor coordination assessed by rota-rod test traction test. On tension recordings, an vitro addition d-tubocurarine inhibited twitch tensions evoked nerve stimulations both cases treatment. Neomycin shifted concentration-response curve to left, dependently on its injection days. These results...
Tobacco smoke contains many toxic chemicals, such as highly unstable free radicals, reactive oxygen species, and carbonyl compounds acrolein. Crocetin, a natural carotenoid found in plants, has various biological properties, including antioxidant activity. In this study, we investigated the effect of crocetin on muscular injury induced by cigarette extract (CSE) acrolein using murine myoblast C2C12 cells an in-vitro model. Exposure to CSE or decreased cell viability increased death....
Many glaucoma treatments focus on lowering intraocular pressure (IOP), with novel drugs continuing to be developed. One widely used model involves raising IOP by applying a laser the trabecular iris angle (TIA) of cynomolgus monkeys damage meshwork. This model, however, presents challenges such as varying values, potential meshwork damage, and risk animal distress. study investigated whether animals naturally high (>25 mmHg) could effectively evaluate IOP-lowering drugs, thereby possibly...