A5035675112- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Neurogenetic and Muscular Disorders Research
- Retinal Imaging and Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Amyotrophic Lateral Sclerosis Research
- Alzheimer's disease research and treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Antioxidant Activity and Oxidative Stress
- Connexins and lens biology
- Angiogenesis and VEGF in Cancer
- Retinal and Optic Conditions
- Heme Oxygenase-1 and Carbon Monoxide
- Parkinson's Disease Mechanisms and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Saffron Plant Research Studies
- Genetic Neurodegenerative Diseases
- Retinoids in leukemia and cellular processes
- Intracranial Aneurysms: Treatment and Complications
Gifu Pharmaceutical University
2015-2024
Fukuoka University
2020-2022
Showa University
2018-2021
Tokyo University of Agriculture
2018
Showa University Dental Hospital
2018
Showa University Hospital
2018
Ehime University
2017
Novartis (Japan)
2013
Tokyo University of Marine Science and Technology
2011-2012
Osaka Medical and Pharmaceutical University
2011
Abstract After intracranial hemorrhage (ICH), iron is released from the hematoma and induces secondary brain injury. However, detail effect of on blood-brain barrier (BBB) function still unknown. We investigated whether hemoglobin (Hb), ferrous ammonium sulfate (FAS) or hemin which contains have detrimental both human microvascular endothelial cells pericytes by cellular analysis in vitro . developed an (Fe 2+ )-detectable probe, Si-RhoNox-1, to investigate intracellular Fe accumulation...
To determine the mechanism causing degeneration of retinal pigment epithelium (RPE) and photoreceptors in mice after an intravenous injection sodium iodate (NaIO3).The time-dependent changes NaIO3-induced were determined by analyzing morphology optical coherence tomographic (OCT) images, histological sections retina, physiology retina electroretinography (ERG), blood flow laser speckle flowgraphy. In addition, expression genes associated with age-related macular humans was assessed...
The study evaluated the protective effects of purple rice ( Oryza sativa L.) bran extract (PRE) and its constituents, cyanidin peonidin, against angiogenesis induced by vascular endothelial growth factor (VEGF). VEGF PRE were examined in vitro tube formation assays following 14‐day co‐culture human umbilical vein cells (HUVECs) fibroblasts. antiangiogenic mechanism was VEGF‐induced proliferation migration HUVECs and/or retinal microvascular (HRMECs) phosphorylation extracellular...
The present study investigated the vitrification-induced deterioration of mitochondrial functions that may reduce developmental ability post-warming bovine embryos. In addition, effect supplementation culture medium with resveratrol on and embryonic development was examined. Two days after in vitro fertilization, embryos 8–12 cells (referred to hereafter as 8-cell embryos) were vitrified warmed, followed by incubation for 5 a containing either vehicle or 0.5 μM resveratrol. Vitrification...
Non-exudative age-related macular degeneration (AMD) is an irreversibly progressive retinal degenerative disease characterized by dysfunction and loss of pigment epithelium (RPE). It has been suggested that impaired phagocytosis the RPE involved in progression non-exudative AMD, but mechanism not fully clear. In this study, we investigated effect lipid droplet accumulation on function. Compared to young mice, expression droplet-associated proteins increased RPE-choroidal complex, was...
Spinal muscular atrophy (SMA) is a motor neuron disease, typically resulting from loss-of-function mutations in the survival 1 (SMN1) gene. Nusinersen/SPINRAZA, splice-switching oligonucleotide that modulates SMN2 (a paralog of SMN1) splicing and consequently increases SMN protein levels, has therapeutic effect for SMA. Previously reported small-molecule modulators such as risdiplam/EVRYSDI its analog SMN-C3 modulate not only but also secondary splice targets, including forkhead box M1...
Abstract Background Blue light exposure is known to induce reactive oxygen species (ROS) production and increased endoplasmic reticulum stress, leading apoptosis of photoreceptors. Maqui berry ( Aristotelia chilensis ) a fruit enriched in anthocyanins, for beneficial biological activities such as antioxidation. In this study, we investigated the effects extract (MBE) its constituents on subcellular damage induced by blue irradiation mouse retina-derived 661W cells. Methods We evaluated MBE...
This study aimed to characterize the functional and morphologic changes in a murine model of ocular ischemic disease caused by vascular occlusion.Retinal ischemia was induced unilateral ligation pterygopalatine artery (PPA) external carotid (ECA) anesthetized mice. Changes blood flow retinal circulation were evaluated three different methods: laser speckle imaging, fundus fluorescein isothiocyanate angiography. Five days after reperfusion following 3- or 5-hour ischemia, an electroretinogram...
The mouse model of oxygen-induced retinopathy (OIR) has been widely used for studies prematurity (ROP). This disorder, characterized by abnormal vascularization the retina, tends to occur in low birth weight neonates after exposure high supplemental oxygen. Currently, incidence ROP is increasing because increased survival these infants due medical progress. However, little known about changes chronic phase ROP. Therefore, this study, we examined morphological and functional retina using a...
Endoplasmic reticulum (ER) stress occurs as a result of accumulation unfolded or misfolded proteins in the ER and is involved mechanisms various diseases, such cancer neurodegeneration. The goal present study was to clarify relationship between pathological neovascularization retina. Proliferation migration human retinal microvascular endothelial cells (HRMEC) were assessed presence inducers, tunicamycin thapsigargin. expression chaperone immunoglobulin heavy-chain binding protein (BiP),...
Inflammatory response has a critical role in neuronal damage after retinal ischemia-reperfusion (I/R) injury, and is regulated tightly by the toll-like receptor (TLR) 4. This study aimed to determine whether TLR4 involved with injury an ocular ischemic syndrome mice model clarify downstream pathway of TLR4.To cause ischemia, we ligated unilateral external carotid artery pterygopalatine for 5 hours. Five days reperfusion, histologic analysis was performed. To examine TLR4, analyzed changes...
Non-exudative age-related macular degeneration (AMD) is mainly caused by the accumulation of lipofuscin and drusen on retinal pigment epithelium (RPE). Both oxidative stress autophagic dysfunction accelerate deposition at RPE. One key regulators in response against NF-E2-Related Factor 2 (Nrf2)-kelch like ECH associated protein 1 (Keap1) axis, which also closely with autophagy pathway. Nrf2 activation upregulates expression levels certain anti-oxidative enzymes [e.g. Heme oxygenase-1...
Several antitumour drugs have been isolated from natural products and many clinical trials are underway to evaluate their potential. There numerous reports about the effects of astaxanthin against several tumours but no studies into its glioblastoma. Astaxanthin is a red pigment found in crustaceans fish also synthesized Haematococcus pluvialis; adonixanthin an intermediate product astaxanthin. It known that both possess radical scavenging activity can confer protective effect on damages. In...
Abstract The cornea is directly exposed to cigarette smoke, and smoking a risk factor for several corneal diseases including dry eye syndrome. Currently, heated tobacco products (HTPs) are widely used as substitutes around the world. In present study, we investigated molecular mechanism(s) leading cellular injury induced by smoke extract (CSE) or HTPs. Exposure CSE perturbed formation of tight junctions, an increase in cell volume, decrease transepithelial electrical resistance (TER) human...