A5024715414- Quantum and electron transport phenomena
- Physics of Superconductivity and Magnetism
- Aortic aneurysm repair treatments
- Rare-earth and actinide compounds
- Peripheral Artery Disease Management
- Vascular Procedures and Complications
- Aortic Disease and Treatment Approaches
- Thermodynamic and Structural Properties of Metals and Alloys
- Microstructure and mechanical properties
- Spectral Theory in Mathematical Physics
- Magnesium Alloys: Properties and Applications
- Infectious Aortic and Vascular Conditions
- Magnetic and transport properties of perovskites and related materials
- Coronary Artery Anomalies
- Game Theory and Voting Systems
- Magnetic Properties and Applications
- Renal and Vascular Pathologies
- Magnetic properties of thin films
- Aluminum Alloys Composites Properties
- Antimicrobial Peptides and Activities
- Advanced Chemical Physics Studies
- Probiotics and Fermented Foods
- Optimization and Search Problems
- RNA Research and Splicing
- Abdominal vascular conditions and treatments
National Institute of Advanced Industrial Science and Technology
2023-2024
Tohoku University Hospital
2017-2023
Tokyo University of Agriculture
2019-2023
Tohoku University
1998-2022
The University of Tokyo
2022
Red Cross Hospital
2022
Kyoto University
1999-2020
Wakayama University
2020
Takeda (Japan)
2013
Hiroshima University
2001
Spinal muscular atrophy (SMA) is a motor neuron disease, typically resulting from loss-of-function mutations in the survival 1 (SMN1) gene. Nusinersen/SPINRAZA, splice-switching oligonucleotide that modulates SMN2 (a paralog of SMN1) splicing and consequently increases SMN protein levels, has therapeutic effect for SMA. Previously reported small-molecule modulators such as risdiplam/EVRYSDI its analog SMN-C3 modulate not only but also secondary splice targets, including forkhead box M1...
The maximum axial diameter (MAD) of a fusiform abdominal aortic aneurysm (AAA) is an indicator the risk expansion or rupture. Apart from smoking and MAD itself, few factors have been reported. In this study, we investigated for AAA.Methods Results:This retrospective cohort study included 176 patients who attended Tohoku University Hospital with infrarenal AAA. AAA rate was determined on multidetector computed tomography, correlations between clinical data were analyzed. median 2.405 mm/year....
Previous studies have suggested that some Lactobacillus S-layer proteins could modulate immune responses. Primary structures of the are variable, and their immunological differences poorly understood. In this study, we evaluated properties eight distinct from different species. We found removal cell surface reduced activities cells in THP-1 cells. Furthermore, purified induced production IL-12 p40, although varied between proteins. The p40 was notably by protein SLP(aly) amylolyticus NRIC...
We approach the helimagnetic structure of itinerant-electron magnet YMn2, in which Mn sublattice forms a geometrically frustrated corner-sharing tetrahedral lattice, by means both low-energy neutron diffraction and precise nuclear magnetic resonance (NMR) experiments, modifying state Tb substitution (the introduction lattice inhomogeneity), considering origin tetragonal distortion detected below TN. The spin reorientation induced from helical with propagation vector = [τ01] (τ 0.018) spins...
Based on the Quantum Monte Carlo (QMC) technique, we developed a method to calculate tunneling conductance of quantum dot systems for which Kondo effect becomes important. The computes directly from current correlation function, and is applicable cases in calculation not reduced computation single particle Green's function. We compare calculated with experiments, found good qualitative agreement. temperature experiments seems be low enough compared mid region two paired Coulomb oscillation...
There is usually a tradeoff between the strength and ductility in solute strengthening of metallic materials. However, magnesium an exception. A {101¯1}-{101¯2} double twin (DT) provides fracture-initiation site Mg. Hence, investigation on effects segregations facture at DT will give clue for understanding exception Mg to relation. In present work, we investigated segregation behavior Y Al interactions screw dislocation with segregated DTs by Monte Carlo (MC) molecular dynamics (MD)...
Objectives: The optimal surgical management for primary infected abdominal aortic aneurysm (IAAA) is controversial. Here, we report the early and long-term results of treatments with resection IAAA in situ graft reconstruction pedicled omental coverage that was performed at out hospital. Methods: Between 2010 2017, 27 consecutive patients (26 males, 1 female, median age 69 years) were surgically treated IAAA, covered a flap. Perioperative outcomes reviewed retrospectively by medical records....
The roles of mechanical size and chemical bonding effect segregated elements in grain boundaries (GBs) on the interactions between GBs dislocations are still not well understood. Because a twist GB tends to have higher energy than tilt owing its random structure, effects solute dislocation-GB generally different from those GB. In addition, dislocation emission hcp metals is more complex that fcc because intense plastic anisotropy metals. this study, basal 〈a〉 edge were studied non-segregated...
Ligilactobacillus agilis is a motile lactic acid bacterium found in the gastrointestinal tracts of animals. The findings our previous study suggest that motility L. BKN88 enables gut colonization murine models. However, chemotactic abilities lactobacilli remain unknown. This aimed to identify gut-derived chemoeffectors and their corresponding chemoreceptors BKN88. Chemotaxis assays with non-chemotactic (ΔcheA) strains revealed low pH, organic acids, bile salts served as repellents. was more...
The single-particle and the magnetic excitation spectra at finite temperatures, transport coefficients are calculated for impurity Anderson Hamiltonian by using numerical renormalization group method. results 2-fold 4-fold degenerate models compared. show similar temperature dependence when have same occupation number ratio to degeneracy number. But coefficients, similarity is limited very low temperatures. of model agree with experimental dilute Ce ion in LaB 6 .
We investigate the non-Fermi-liquid (NFL) behavior of impurity Anderson model (IAM) with non-Kramers doublet ground state f 2 configuration under tetragonal crystalline electric field (CEF). The low energy spectrum is explained by a combination NFL and local-Fermi-liquid parts which are independent each other. part has same form to that two-channel-Kondo (TCKM). have parameter range IAM shows - ln T divergence magnetic susceptibility together positive magneto resistance. point out...
We developed a Monte Carlo method to study the magnetic and transport properties of low density carrier ferromagnetic (FM) semiconductors. The calculation is carried out for two- three-dimensional Ising spin system interacting with electrons through s-d exchange coupling. When temperature increases from T =0, spontaneous magnetization local spins decreases appreciably in range, steeply at Curie ( C ). initial decrease caused by almost complete escape flipped sites, accumulation FM region....
Objective: Renal artery aneurysm (RAA) is an uncommon disease, the natural course of which still not well known. The objective this study to define factors that affect growth rate RAAs. Materials and Methods: We retrospectively reviewed 32 aneurysms in 26 patients at our institute between January 2010 March 2016. Basal demographics, comorbidities, reason for diagnosis, details interventions were recorded. chronological changes diameter RAA using multiplanar reconstructions computed...
Xenopus laevis tadpoles possess high regenerative ability and can regenerate functional tails after amputation. An early event in regeneration is the induction of undifferentiated cells that form regenerated tail. We previously reported interleukin-11 (il11) upregulated immediately tail amputation to induce different cell lineages, indicating a key role il11 initiating regeneration. As Il11 secretory factor, receptor-expressing are thought mediate its function. X. has gene annotated as...
Segregation at a triple junction of grain boundaries has not been explained much because the structure is very complicated. The present paper describes Monte Carlo simulations by which Y segregation was investigated {101¯1}–{101¯2} double twin in Mg. atoms segregated extension sites {101¯1} and {101¯2} boundaries. However, they were necessarily more twin, although free volumes larger on average than those other Thus, behavior cannot be only volume. anisotropic factor atomic Voronoi...
Objective: To examine the medium- to long-term outcomes of acute limb ischemia (ALI), which are unclear at present. Methods: We analyzed 93 consecutive limbs in 77 patients with ALI between January 2005 and December 2015 treated our vascular center. categorized cases into four groups according etiology (embolism, thrombosis, graft dissection groups) assess survival, salvage, freedom from re-intervention rates. Results: The mean age onset was 72±15 years. median follow-up length 2.90...