A5063385140- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Intraperitoneal and Appendiceal Malignancies
- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- Hernia repair and management
- Urinary and Genital Oncology Studies
- Cancer-related molecular mechanisms research
- Pelvic floor disorders treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Pelvic and Acetabular Injuries
- Testicular diseases and treatments
- Liver Disease Diagnosis and Treatment
- Renal cell carcinoma treatment
- Liver Disease and Transplantation
- Management of metastatic bone disease
- IgG4-Related and Inflammatory Diseases
- Electron Spin Resonance Studies
- Musculoskeletal synovial abnormalities and treatments
- Gestational Trophoblastic Disease Studies
- Soft tissue tumors and treatment
University of Cambridge
2010-2024
Addenbrooke's Hospital
2010-2024
Cambridge University Hospitals NHS Foundation Trust
2011-2024
Cancer Research UK Cambridge Center
2016-2021
Bridge University
2019-2021
Cancer Research UK
2019-2020
Siemens Healthcare (Germany)
2019
McGill University Health Centre
2013
Montreal General Hospital
2011-2013
McGill University
2012-2013
Circulating tumour DNA (ctDNA) carrying tumour-specific sequence alterations may provide a minimally invasive means to dynamically assess burden and response treatment in cancer patients. Somatic TP53 mutations are defining feature of high-grade serous ovarian carcinoma (HGSOC). We tested whether these could be used as personalised markers monitor early changes predictor time progression (TTP).
To investigate magnetic resonance (MR) volumetry of endometrial tumors and its association with deep myometrial invasion, tumor grade, lymphovascular invasion to assess the value apparent diffusion coefficient (ADC) histographic analysis whole volume for prediction grade invasion.The institutional review board approved this retrospective study; patient consent was not required. Between May 2010 2012, 70 women (mean age, 64 years; range, 24-91 years) cancer underwent preoperative MR imaging,...
Endometrial cancer is the most commonly diagnosed gynecologic malignancy in United States. This pathologic condition staged with International Federation of Gynecology and Obstetrics (FIGO) system. The FIGO staging system recently underwent significant revision, which has important implications for radiologists. Key changes incorporated into 2009 include simplification stage I disease removal cervical mucosal invasion as a distinct stage. Magnetic resonance (MR) imaging essential...
Abstract High grade serous ovarian carcinoma (HGSOC) is a highly heterogeneous disease that typically presents at an advanced, metastatic state. The multi-scale complexity of HGSOC major obstacle to predicting response neoadjuvant chemotherapy (NACT) and understanding critical determinants response. Here we present framework predict the patients NACT integrating baseline clinical, blood-based, radiomic biomarkers extracted from all primary lesions. We use ensemble machine learning model...
Gynecologic malignancies account for 10%-15% of all in females. A variety oncologic options are available depending on organ origin, histologic diagnosis, and disease grade stage. usually treated with surgery, chemotherapy, or radiation therapy. Posttreatment imaging plays a crucial role the assessment treatment response tumor recurrence. Imaging female pelvis following chemotherapy therapy is particularly challenging due to alteration normal anatomy loss tissue planes. Expected changes...
To determine the accuracy of interpretation a non-contrast MRI protocol in characterizing adnexal masses.Two hundred ninety-one patients (350 masses) who underwent gynecological at our institution between 1st January 2008 and 31st December 2018 were reviewed. A random subset (102 with 121 was chosen to evaluate reproducibility repeatability readers' assessments. Readers evaluated scans retrospectively, assigned 5-point score for risk malignancy gave specific diagnosis. The reference standard...
Background Pathological response to neoadjuvant treatment for patients with high-grade serous ovarian carcinoma (HGSOC) is assessed using the chemotherapy score (CRS) omental tumor deposits. The main limitation of CRS that it requires surgical sampling after initial (NACT) treatment. Earlier and non-invasive predictors could improve patient stratification. We developed computed tomography (CT) radiomic measures predict before NACT as a gold standard. Methods Omental CT-based radiomics...
Abstract Purpose To develop a precision tissue sampling technique that uses computed tomography (CT)–based radiomic tumour habitats for ultrasound (US)-guided targeted biopsies can be integrated in the clinical workflow of patients with high-grade serous ovarian cancer (HGSOC). Methods Six suspected HGSOC scheduled US-guided biopsy before starting neoadjuvant chemotherapy were included this prospective study from September 2019 to February 2020. The segmentation was performed manually on...
T2-weighted sequences are an integral part of magnetic resonance (MR) imaging performed for the characterization adnexal lesions. A relatively small number these lesions demonstrate low signal intensity on MR images. In majority cases, a specific diagnosis can be made by interpreting lesion with respect to certain pathologic correlates, including blood products, smooth muscle, fibrous tissue, and calcification, as well high cellularity. For example, that at least dark skeletal muscle almost...
Purpose: To evaluate rectal cancer volumetry in predicting initial neoadjuvant chemotherapy response. Materials and Methods: Sixteen consecutive patients who underwent (CX) before chemoradiotherapy (CRT) surgery were enrolled this retrospective study. Tumor volume was evaluated at the first magnetic resonance imaging (MRI), after CX CRT. regression (TVR) downstaging compared with histological results according to Regression Grade (TRG) assess CRT response, respectively. Results: The mean...
The aim of this study was to assess the feasibility rapid sodium MRI (23Na-MRI) for imaging peritoneal cancer deposits in high grade serous ovarian (HGSOC) and evaluate relationship 23Na-MRI with tumour cellularity. performed at 3 T on twelve HGSOC patients using a 3D-cones acquisition technique. Tumour biopsies specimens were collected after cellularity measured from histology. Total scan time each patient approximately 11 min. At an isotropic resolution 5.6 mm, signal-to-noise ratios...