A5001003938- Glaucoma and retinal disorders
- Neuroscience and Neural Engineering
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Vagus Nerve Stimulation Research
- EEG and Brain-Computer Interfaces
- Wireless Power Transfer Systems
- Semiconductor materials and devices
- Wireless Body Area Networks
- Molecular Communication and Nanonetworks
- Anesthesia and Neurotoxicity Research
- Head and Neck Surgical Oncology
- Craniofacial Disorders and Treatments
- Heart Rate Variability and Autonomic Control
- Ferroelectric and Negative Capacitance Devices
- Ophthalmology and Eye Disorders
- Retinal and Macular Surgery
- Advancements in Semiconductor Devices and Circuit Design
- Neurological disorders and treatments
- Photoreceptor and optogenetics research
Purdue University West Lafayette
2017-2022
Orano (United States)
2022
IBM (United States)
2011
Abstract Continuous monitoring of intraocular pressure, particularly during sleep, remains a grand challenge in glaucoma care. Here we introduce class smart soft contact lenses, enabling the continuous 24-hour even sleep. Uniquely, lenses are built upon various commercial brands without altering their intrinsic properties such as lens power, biocompatibility, softness, transparency, wettability, oxygen transmissibility, and overnight wearability. We show that can seamlessly fit across...
We present a sub-mm3, fully wireless, implantable intraocular pressure monitor microsystem (IMM) that comprises powering coil, an antenna, piezoresistive micro-electro-mechanical system sensor, and sensing IC. The provides 24-h monitoring, which is not possible with currently used tonometric measurements. IMM volume limited to 0.38 mm3 (4 × smaller than previous state-of-the-art) for the studies on laboratory rodents prior human use. A cavity resonator magnetic coupling delivers wireless...
We present a wireless, fully implantable device for electrical stimulation of peripheral nerves consisting powering coil, tuning network, Zener diode, selectable parameters, and stimulator IC, all encapsulated in biocompatible silicone. A wireless RF signal at 13.56 MHz powers the implant through on-chip rectifier. The ASIC, designed TSMC's 180 nm MS G process, occupies an area less than 1.2 mm2. IC enables externally current-controlled read-only memory with wide range 32 parameters (90-750...
Heart disease is the leading cause of death worldwide. Hypertension an important precursor and most common risk factor to heart failure. While some patients can control their high blood pressure with pharmaceuticals, many suffer from resistant hypertension, where antihypertensive medications do not achieve desired outcome. Electrical stimulation emerging therapy modulate integrating it closed-loop feedback improve control.We design fabricate two application-specific integrated circuits...
Current minimally-invasive glaucoma surgery (MIGS) devices promise to control elevated levels of intraocular pressure (IOP) while avoiding many the downsides traditional surgery. However, there remains room for improvement in performance metrics, including drainage efficacy, device longevity, and time implant, as outlined by benchmarks set forth Audacious Goals Initiative. We introduce a better shunt, which achieves similar or improved pre-clinical safety efficacy outcomes commercial MIGS...
In contrast to the generally accepted expectation that mismatch is monotonically related doping level for uniformly channels, apparently anomalous results in which short-channel low-doped devices have larger than higher doped high-threshold are shown. However, these fully explained and comprehended context of device design random dopant fluctuation, correlation effect with suggests yet another manner depleted undoped-body will offer better variation classic scaled dopant-driven transistors,...
Crouzon and Apert syndromes are rare genetic disorders characterized by craniosynostosis, a condition with premature fusion of sutures the skull bones, which is occasionally associated epilepsy. We report case patient syndrome medically refractory temporal lobe epilepsy encephaloceles that experienced near sudden unexpected death in (SUDEP) event. This illuminates both need to consider as treatable lesional etiology craniosynostosis postictal apnea may be an important mechanism...
Purpose: To investigate the safety and efficacy of IOPTx™ system – a novel wearable, electroceutical treatment to lower intraocular pressure. Methods: Patients wear customized contact lens spectacles undergo three 15-minute randomized stimulation trials at different stimulus amplitudes with 15 minutes rest in between. The parameters for include frequency 50 Hz, pulse width 100 µs, current between 90–150 µA. optometrist measures pressure (IOP) before, immediately after, after trial, performs...