A5045470107- Single-cell and spatial transcriptomics
- Phytochemistry and Biological Activities
- Protein Degradation and Inhibitors
- Gene Regulatory Network Analysis
- Gene expression and cancer classification
- Plant Toxicity and Pharmacological Properties
- Phytoplasmas and Hemiptera pathogens
- Heat shock proteins research
- Chromatography in Natural Products
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Plant Molecular Biology Research
- Biochemical Analysis and Sensing Techniques
- Protein Tyrosine Phosphatases
- Microbial Natural Products and Biosynthesis
- Ubiquitin and proteasome pathways
- Cocoa and Sweet Potato Agronomy
- Insect symbiosis and bacterial influences
- Histone Deacetylase Inhibitors Research
- Allelopathy and phytotoxic interactions
- Plant biochemistry and biosynthesis
- Leaf Properties and Growth Measurement
- Botanical Research and Chemistry
- PI3K/AKT/mTOR signaling in cancer
- Natural product bioactivities and synthesis
Shanxi University
2024
Shanghai Jiao Tong University
2021-2022
Shanghai Medical College of Fudan University
2012-2016
Fudan University
2015
South China Botanical Garden
2004-2009
Ministry of Education of the People's Republic of China
2009
Chinese Academy of Sciences
2004
The protein-tyrosine phosphatase (PTP) Shp2 has been implicated in many immunoreceptor signaling pathways, but its role FcεRI signaling, which leads to the activation of mast cells and blood basophils, is still largely undefined. Using knockdown RBL-2H3 (RBL) cells, we here reported that required for RBL induced by FcεRI. FcεRΙ-evoked degranulation, calcium mobilization, synthesis cytokine transcripts (IL-1β, IL-10, monocyte chemoattractant protein 1 (MCP-1)) were reduced cells. Signaling...
DNA methylation is a highly conserved epigenetic modification involved in many biological processes, including growth and development, stress response, secondary metabolism. demethylase (DNA-deMTase) genes have been identified some plant species; however, there are no reports on the identification analysis of DNA-deMTase Foxtail millet (Setaria italica L.). In this study, seven DNA-deMTases were S. italica. These divided into four subfamilies (DML5, DML4, DML3, ROS1) by phylogenetic gene...
Abstract magnified image A new guaiane sesquiterpene, (1 β ,6 α ,10 )‐guai‐4(15)‐ene‐6,7,10‐triol ( 1 ), and a lignan, (+)‐lariciresinol 9′‐stearate 2 were isolated from the aerial parts of leguminosae plant, Tephrosia vogelii , together with three known compounds, teclenone B, ,7 R *)‐opposit‐4(15)‐ene‐1,7‐diol, pinoresinol. Their structures elucidated on basis spectral data.
Twenty-two β-resorcylic acid lactones (RALs) were evaluated for cytotoxicity against human breast cancer cells to find their structure–activity relationship (SAR). Monocillin II, a trans-enone RAL without epoxy and conjugated dienone, was found have higher activity in inhibiting tumor cell growth both vitro experiment vivo nude xenografted mice model than its analogue radicicol, an anticancer lead compound. We demonstrated the first time that monocillin II could arrest cycle G1 phase, which...
In the summer of 2008, phyllody and enlarged petioles resembling symptoms phytoplasma infection were observed on clover (Trifolium repens) plants in lawns campus Northwest A&F University. Typical phytoplasma-like bacteria phloem cells when ultra-thin sections from leaf midrib tissues examined with transmission electron microscopy. Nested PCR assays used to verify association disease. Total DNA was extracted midribs 20 symptomatic six symptomless using modified CTAB method (1). Using...
Many computational methods have been developed to infer causality among genes using cross-sectional gene expression data, such as single-cell RNA sequencing (scRNA-seq) data. However, due the limitations of scRNA-seq technologies, time-lagged causal relationships may be missed by existing methods. In this work, we propose a method, called inference with information (CITL), from data assessing conditional independence between changing and current levels genes. CITL estimates "RNA velocity"....
Abstract Many computational methods have been developed for inferring causality among genes using cross-sectional gene expression data, such as single-cell RNA sequencing (scRNA-seq) data. However, due to the limitations of scRNA-seq technologies, time-lagged causal relationships may be missed by existing methods. In this work, we propose a method, called inference with information (CITL), infer from data assessing conditional independence between changing and current levels genes. CITL...