A5031010317- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Genomics and Chromatin Dynamics
- Galectins and Cancer Biology
- Microtubule and mitosis dynamics
- 3D Printing in Biomedical Research
- DNA Repair Mechanisms
- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- Immune cells in cancer
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- Chromosomal and Genetic Variations
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
Rockefeller University
2020-2023
University of California, Berkeley
2013-2018
TU Dresden
2010
Cell shape and motility are primarily controlled by cellular mechanics. The attachment of the plasma membrane to underlying actomyosin cortex has been proposed be important for processes involving deformation. However, little is known about actual function membrane-to-cortex (MCA) in cell protrusion formation migration, particular context developing embryo. Here, we use a multidisciplinary approach study MCA zebrafish mesoderm endoderm (mesendoderm) germ layer progenitor cells, which migrate...
Significance Targeting myeloid cells represents a promising strategy to augment antitumor immunity and overcome resistance existing T cell-targeting therapies. However checkpoints that can be effectively used as immunotherapy targets are still lacking. Here, we demonstrate the therapeutic potential of targeting Siglec-7 Siglec-9 enhance in vivo. Using an immunocompetent mouse model humanized for Siglec-7/9, show these receptors inhibit endogenous immune response tissue-specific manner. These...
Significance Here we report that targeting the pattern recognition receptor MARCO on macrophages within tumor alters their polarization and in turn activate natural killer (NK) cells to kill tumor. We describe mechanism of action, including NK are induced use receptor-mediated killing cancer cells. Furthermore, find this type treatment works combination with T cell-targeted checkpoint therapies. then transfer finding humans similar subpopulations human also block Finally, these a new...
Abstract Despite the curative potential of checkpoint blockade immunotherapy, most patients remain unresponsive to existing treatments. Glyco-immune checkpoints – interactions cell-surface glycans with lectin, or glycan-binding, immunoreceptors have emerged as prominent mechanisms immune evasion and therapeutic resistance in cancer. Here, we describe antibody-lectin chimeras (AbLecs), a modular platform for glyco-immune blockade. AbLecs are bispecific antibody-like molecules comprising...
Mitotic spindle disassembly after chromosome separation is as important assembly, yet the molecular mechanisms for are unclear. In this study, we investigated how chromosomal passenger complex (CPC), which contains Aurora B kinase Ipl1, swiftly concentrates at midzone in late anaphase, and researched role of dramatic relocalization during disassembly. We showed that kinesins Kip1 Kip3 essential CPC relocalization. cells lacking Kip3, severely delayed until contraction cytokinetic ring....
<h3>Background</h3> Despite the curative potential of checkpoint blockade immunotherapy, a majority patients remain unresponsive to existing treatments. Glyco-immune checkpoints – interactions cell-surface glycans with lectin, or glycan binding, immunoreceptors have emerged as prominent mechanisms immune evasion and therapeutic resistance in cancer. <h3>Methods</h3> Here, we describe antibody-lectin chimeras (AbLecs), modular platform for glyco-immune blockade. AbLecs are bispecific...
<h3>Background</h3> Cancer immunotherapies, including checkpoint blockade antibodies, represent a breakthrough in cancer treatment with long-term remission observed select patients. Unfortunately, many tumors remain unresponsive to existing creating an urgent need therapeutically target additional immune checkpoints that drive progression. Glyco-immune – which cell-surface biopolymers decorated sugars, or glycans, engage glycan-binding receptors on cells have emerged as modulatory pathways...