A5053062159- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Phagocytosis and Immune Regulation
- Pancreatic and Hepatic Oncology Research
- Advanced Biosensing Techniques and Applications
- Cancer Genomics and Diagnostics
- Cellular transport and secretion
- Ubiquitin and proteasome pathways
- Cancer Cells and Metastasis
- Biosimilars and Bioanalytical Methods
- Cell Adhesion Molecules Research
- Renal cell carcinoma treatment
- Advanced Breast Cancer Therapies
- Connective tissue disorders research
- Hepatitis C virus research
- FOXO transcription factor regulation
- Tannin, Tannase and Anticancer Activities
- Apelin-related biomedical research
- Hepatocellular Carcinoma Treatment and Prognosis
- Social Media in Health Education
- Renal and related cancers
- Cancer Mechanisms and Therapy
- Probiotics and Fermented Foods
- Single-cell and spatial transcriptomics
- Cardiac Fibrosis and Remodeling
AstraZeneca (United States)
2025
The University of Texas MD Anderson Cancer Center
2015-2023
Eisai (United States)
2021
Lexicon Pharmaceuticals (United States)
2019
Wake Forest University
2016
UCLA Jonsson Comprehensive Cancer Center
2012-2014
University of California, Los Angeles
2013-2014
University of Colorado Denver
2013
University of Colorado Cancer Center
2013
Institute of Molecular Biology
2013
Epithelial to mesenchymal transition (EMT) is associated with a wide range of changes in cancer cells, including stemness, chemo- and radio-resistance, metastasis. The mechanistic role upstream mediators EMT has not yet been well characterized. Recently, we showed that non-small cell lung cancers (NSCLC) have undergone overexpress AXL, receptor tyrosine kinase. AXL also overexpressed subset triple-negative breast (TNBC) head neck squamous carcinomas (HNSCC), its overexpression more...
Pathogenic microorganisms and toxins have evolved a variety of mechanisms to gain access the host-cell cytosol thereby exert virulent effects upon host. One common mechanism cellular entry requires trafficking an acidified endosome, which promotes translocation across host membrane. To identify small-molecule inhibitors that block this process, library 30,000 small molecules was screened for anthrax lethal toxin. Here we report 4-bromobenzaldehyde N-(2,6-dimethylphenyl)semicarbazone, most...
Stimulation of epidermal growth factor receptor (EGFR) initiates RAS signaling simultaneously with EGFR internalization. Endocytosed is then either recycled or degraded. fate determined in part by the effector RIN1, a guanine nucleotide exchange (GEF) for RAB5 GTPases. degradation was slowed RIN1 silencing, enhanced overexpression and accelerated localization to plasma membrane. also directly activates ABL tyrosine kinases, which regulate actin remodeling, function not previously connected...
PURPOSE Human epidermal growth factor receptor 2 (HER2) is an effective therapeutic target in breast and gastric gastroesophageal junction cancers. However, less known about the prevalence of ERBB2 ( HER2) amplification efficacy HER2-targeted treatment other tumors. PATIENTS AND METHODS We assessed HER2 status among 5,002 patients with advanced disease (excluding cancer) who underwent next-generation sequencing. evaluated clinical benefit therapy by measuring time-dependent overall survival...
574 Background: EMERALD-1 (NCT03778957) met its primary endpoint, demonstrating improved progression-free survival (PFS) in pts with locoregional HCC treated D + B TACE versus placebos (PBO) (stratified Cox proportional hazards hazard ratio [HR], 0.77; 95% confidence interval [CI], 0.61–0.98 [Lencioni R, et al. J Clin Oncol 2024;42(suppl 3). Abs LBA432]). This post hoc analysis assessed outcomes by radiological progression pattern or PBO TACE. Methods: Pts included this received (1500 mg)...
Listeria monocytogenes is a food-borne pathogenic bacterium that invades intestinal epithelial cells through phagocytic pathway relies on the activation of host cell RAB5 GTPases. must subsequently inhibit RAB5, however, in order to escape lysosome-mediated destruction. Relatively little known about upstream regulators during L. entry and phagosome processes cells. Here we identify RIN1, RAS effector RAB5-directed guanine nucleotide exchange factor (GEF), as infection. RIN1 rapidly engaged...
Stimulation of a receptor tyrosine kinase (RTK), such as EGFR, leads to RAS activation followed by RIN1 activation. RIN1, in turn, activates RAB5 family GTPases, well ABL kinases. As expected, expression directly correlates with RAB5-mediated EGFR endocytosis. We previously showed that normal endocytosis and internalized fate also depend on the ability concomitantly activate kinases, consistent established role kinases cytoskeleton remodeling growing evidence plays endocytic processes. Here...
Cell-free DNA (cfDNA) next-generation sequencing is a noninvasive approach for genomic testing. We report the frequency of identifying alterations and their clinical actionability in patients with advanced/metastatic cancer.
11039 Background: The oncology community is embracing social media (SM) platforms like Twitter to gain exposure research, network, and engage in real-time discussions. emergence of SM activity around the ASCO annual meetings has dramatically increased over past 5 years, with factors such as COVID-19 pandemic further accelerating use digital platforms. This growth engagement within previously been presented by totaling quantity tweets a given time frame. Here, we explore impact specific...
Abstract Introduction: Personalized cancer treatment is becoming more tumor agnostic by choosing a based on the genomics rather than type. HER2 an effective therapeutic target with FDA-approved treatments in breast and gastric/gastroesophageal junction (GEJ) cancers; however, less known about efficacy of HER2-targeted other types. Methods: Next-generation sequencing (NGS) was performed 2221 patients (pts) advanced solid tumors CLIA-certified laboratories using multiple platforms for...
Abstract Background: Head and neck squamous cell carcinoma (HNSCC) is the fifth most common cancer. In 2013, there were ∼53,000 newly diagnosed cases ∼11,000 deaths related to HNSCC in USA. Overexpression of EGFR seen 90% HNSCC; but, only ∼10% patients treated with anti-EGFR antibody cetuximab show increased response rates these eventually gain resistance by poorly-characterized mechanisms. We showed an association between EMT inhibitors lung cancers (LC) using a 76-gene signature. AXL was...
Abstract Background: Triple negative breast cancers (TNBCs) account for about 15% of cancer diagnosis in the USA, and occur at a higher percentage among African-American women (about 34%). Although they constitute small percentage, lack targeted therapy these hormone receptor-negative has led to poor prognosis overall survival. The main cause TNBC-associated death is tumor metastasis from primary site distant sites. Characterization drivers EMT, one major could potentially identify...
<div>Abstract<p>Epithelial to mesenchymal transition (EMT) is associated with a wide range of changes in cancer cells, including stemness, chemo- and radio-resistance, metastasis. The mechanistic role upstream mediators EMT has not yet been well characterized. Recently, we showed that non–small cell lung cancers (NSCLC) have undergone overexpress AXL, receptor tyrosine kinase. AXL also overexpressed subset triple-negative breast (TNBC) head neck squamous carcinomas (HNSCC), its...
<div>Abstract<p>The introduction of HER2-targeted therapy for breast and gastric patients with <i>ERBB2</i> (<i>HER2</i>) amplification/overexpression has led to dramatic improvements in oncologic outcomes. In the past 20 years, five therapies have been FDA approved, four approved 8 years. similarly was found improve outcomes HER2-positive cancer. Over decade, next-generation sequencing into clinical practice, our understanding HER2 biology dramatically...
<div>Abstract<p>The introduction of HER2-targeted therapy for breast and gastric patients with <i>ERBB2</i> (<i>HER2</i>) amplification/overexpression has led to dramatic improvements in oncologic outcomes. In the past 20 years, five therapies have been FDA approved, four approved 8 years. similarly was found improve outcomes HER2-positive cancer. Over decade, next-generation sequencing into clinical practice, our understanding HER2 biology dramatically...