A5019513825- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Cardiac pacing and defibrillation studies
- Cardiovascular Disease and Adiposity
- Cardiovascular Effects of Exercise
- Opioid Use Disorder Treatment
- Diabetes Treatment and Management
- Forensic Toxicology and Drug Analysis
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmaceutical Practices and Patient Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Cardiac Imaging and Diagnostics
- Chronic Disease Management Strategies
- Neurotransmitter Receptor Influence on Behavior
- Heart Rate Variability and Autonomic Control
- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- High Altitude and Hypoxia
- Poisoning and overdose treatments
- Coronary Artery Anomalies
University of California, San Francisco
2021-2024
San Francisco General Hospital
2021-2023
ZoneOne Pharma (United States)
2022
University of San Francisco
2021
Johns Hopkins University
2020
University of Minnesota
2012-2017
Mayo Clinic in Arizona
2015-2017
Rigshospitalet
2017
Western University
2017
University of Glasgow
2017
Background: In patients with heart failure and preserved ejection fraction, little is known about the characteristics of, outcomes in, those without diabetes mellitus. Methods: We examined clinical echocardiographic in I-Preserve trial (Irbesartan Heart Failure With Preserved Ejection Fraction) according to history of Cox regression models were used estimate hazard ratios for cardiovascular adjusted predictors, including age, sex, natriuretic peptides, comorbidity. Echocardiographic data...
Reduced heart rate during exercise is common and associated with impaired aerobic capacity in failure preserved ejection fraction (HFpEF), but it remains unknown if restoring exertional through atrial pacing would be beneficial.To determine implanting programming a pacemaker for rate-adaptive improve performance patients HFpEF chronotropic incompetence.Single-center, double-blind, randomized, crossover trial testing the effects of symptomatic incompetence at tertiary referral center (Mayo...
Shortness of breath, chest pain, and palpitations occur as postacute sequelae COVID-19, but whether symptoms are associated with echocardiographic abnormalities, cardiac biomarkers, or markers systemic inflammation remains unknown. In a cross-sectional analysis, we assessed symptoms, performed echocardiograms, measured biomarkers among adults more than 8 weeks after confirmed SARS-CoV-2 infection. We modeled associations between baseline characteristics, findings, using logistic regression....
Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited condition associated with arrhythmias and myocardial dysfunction; however, limited data exist on identifying patients at highest risk. The purpose of the study was to determine whether measures (RV) dysfunction echocardiogram including RV strain were predictive structural disease progression in ARVC. Methods Results A retrospective analysis serial echocardiograms from 40 fulfilling 2010 task force criteria for...
Background Cardiac arrhythmias have been observed among patients hospitalised with acute COVID-19 infection, and palpitations remain a common symptom the much larger outpatient population of survivors in convalescent stage disease. Objective To determine arrhythmia prevalence outpatients after diagnosis. Methods Adults positive test without history were prospectively evaluated 14-day ambulatory electrocardiographic monitoring. Participants instructed to trigger monitor for palpitations....
Atrial fibrillation (AFib) is common in heart failure (HF) with preserved ejection fraction (HFpEF). Current AFib stroke risk prediction models include the presence of HF but do not specifically HFpEF as a factor. Whether history should be used to identify patients who are at has been established.Baseline characteristics and outcomes Irbesartan Heart Failure Preserved Ejection Fraction Trial were analyzed relation AFib. At baseline, 1209 (29.3%) had Of these 557 (13.5%) alone, whereas 670...
Background The Acute Decompensated Heart Failure National Registry (ADHERE) and Get With Guidelines (GWTG) registries have developed simple heart failure (HF) in-hospital mortality risk scores. We hypothesized that HF scores predictive of would perform as well for early postdischarge stratification. Methods Results In this single-center, community-based, retrospective study all consecutive primary hospitalizations (6203 in 3745 patients) from 2000 to 2013, the ADHERE GWTG were calculated...
Exclusive HCV therapy clinical trials with genotype 6 patients in high prevalence areas have been sparse. We analysed the safety and efficacy of two generic, pangenotypic NS5A/NS5B combination oral DAA regimens, primarily genotypes 3 6, a real-world setting: (a) daclatasvir/sofosbuvir (DCV/SOF) ± ribavirin (RBV) (b) Velpatasvir/sofosbuvir (VEL/SOF RBV). Between December 2015 November 2017, data from 522 were analysed, 311 whom treated DCV/SOF RBV for 12/24 weeks (genotype 3: n = 193, 6: 89)...
Fixed-dose combination of isosorbide dinitrate and hydralazine (FDC-I/H) reduced mortality by 43% death or first hospitalization for heart failure (HF) 37% in the African-American Heart Failure Trial (A-HeFT). Reduction makes it difficult to determine effect on hospitalizations unless analysis adjusts as a competing risk.In A-HeFT, 1050 self-identified black patients with moderate severe HF were randomized FDC-I/H placebo. The effects all 30-day readmission rates analyzed. Deaths risks...
Right ventricular (RV) abnormalities are the most common echocardiographic findings in acute COVID-19.1,2 While RV dysfunction is associated with in-hospital mortality COVID-19,3,4 prognostic implications of dilation alone less clear. Similarly, little known about clinical significance and among patients hospitalized COVID-19 compared other respiratory illnesses, such as bacterial pneumonia. We studied association
Background: The Acute Decompensated Heart Failure National Registry (ADHERE) Classification and Regression Tree (CART) algorithm is an accepted method to assess a heart failure (HF) patient’s risk of inpatient mortality based on the systolic blood pressure (≥115 vs. <115 mmHg), urea nitrogen (BUN; ≥43 <43 mg/dL), creatinine (≥2.75 <2.75 mg/dL) at time admission. Whether ADHERE CART identifies longer term poor outcomes predictive in patients with (EF < 50%) or diastolic ≥ HF...
Water immersion-induced skin wrinkling (WISW) is dependent on intact peripheral sympathetic function. WISW was hypothesized to reflect autonomic function in subjects without neuropathy. We prospectively studied 70 healthy (aged 31 ± 8 years, 63% females) cardiovascular risk factors or neurological disease. All underwent short-term heart rate variability (HRV) studies. Time and frequency domain variables were derived including the HRV index. graded using a previously validated scale of 1-4...
Abstract Background Methamphetamine use has increased dramatically over the past decade and is associated with development of heart failure (HF). However, clinical characteristics outcomes have not been well described. This study aimed to compare among individuals HF who do methamphetamines in a safety-net hospital. Method retrospective matched cohort included all history methamphetamine age, gender-, year-matched controls without within municipal health system from 2001-2019. 1,783 were...
ABSTRACT BACKGROUND Shortness of breath, chest pain, and palpitations occur as post-acute sequelae COVID-19 (PASC), but whether symptoms are associated with echocardiographic abnormalities, cardiac biomarkers, or markers systemic inflammation remains unknown. METHODS In a cross-sectional analysis, we assessed symptoms, performed echocardiograms, measured biomarkers among adults >8 weeks after PCR-confirmed SARS-CoV-2 infection. We modeled associations between baseline characteristics,...
Chagas disease is an endemic protozoan with high prevalence in Latin America. Of those infected, 20–30% will develop chronic cardiomyopathy (CCC) however, prediction using existing clinical criteria remains poor. In this study, we investigated the utility of left ventricular (LV) echocardiographic speckle-tracking global longitudinal strain (GLS) for early detection CCC. 139 asymptomatic T. cruzi seropositive subjects normal heart size and LV ejection fraction (EF) (stage A or B) were...
Background: Chagas disease is an endemic protozoan with high prevalence in Latin America. Of those infected, 20-30% will develop chronic cardiomyopathy (CCC) however, prediction using existing clinical criteria remains poor. In this study, we investigated the utility of left ventricular (LV) echocardiographic speckle-tracking global longitudinal strain (GLS) for early detection CCC.Methods and results: 139 asymptomatic T. cruzi seropositive subjects normal heart size LV ejection fraction...