A5080336020- Inflammasome and immune disorders
- Bacteriophages and microbial interactions
- Escherichia coli research studies
- Gastrointestinal motility and disorders
- Infant Nutrition and Health
- Immune Cell Function and Interaction
- Cell death mechanisms and regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Burkholderia infections and melioidosis
- Sodium Intake and Health
- Inflammatory Bowel Disease
- Glycosylation and Glycoproteins Research
- Erythrocyte Function and Pathophysiology
- Immune cells in cancer
University of North Carolina at Chapel Hill
2015-2022
Abstract The Western diet is characterized by high protein, sugar, fat, and low fiber intake, widely believed to contribute the incidence pathogenesis of inflammatory bowel disease (IBD). However, sodium chloride salt content, a defining feature processed foods, has not been considered as possible environmental factor that might drive IBD. We set out bridge this gap. examined murine models colitis on either (HSD) or diet. demonstrate an HSD exacerbates pathology in IL-10–deficient model...
Abstract Our lab has shown that inflammasome-triggered pyroptosis ejects microbes from replication niches in macrophages, exposing them to neutrophil killing. Because bona fide intracellular pathogens must evade vivo, the role of defense primarily been observed deprived evasion strategies. To identify naturally occurring bacteria are cleared via pyroptosis, we considered specific chronic granulomatous disease (CGD), a killing deficiency. We hypothesize subset these may be detected by...