A5086113351- Cephalopods and Marine Biology
- Neurobiology and Insect Physiology Research
- Lung Cancer Research Studies
- Advanced Electron Microscopy Techniques and Applications
- Erythrocyte Function and Pathophysiology
- Advanced Fluorescence Microscopy Techniques
- Cell Image Analysis Techniques
- Cancer, Stress, Anesthesia, and Immune Response
- Skin and Cellular Biology Research
- Neuroscience and Neural Engineering
- Connexins and lens biology
- Blood properties and coagulation
- Brain Metastases and Treatment
- Memory and Neural Mechanisms
- Ion channel regulation and function
- Olfactory and Sensory Function Studies
- Ion Channels and Receptors
- Neuroscience and Neuropharmacology Research
- Chemical synthesis and alkaloids
Brigham and Women's Hospital
2023-2024
Howard Hughes Medical Institute
2023
Harvard University
2021-2023
Across mammalian skin, structurally complex and diverse mechanosensory end organs respond to mechanical stimuli enable our perception of dynamic, light touch. How forces act on morphologically dissimilar the skin gate requisite mechanotransduction channel Piezo2 excite neurons is not understood. Here, we report high-resolution reconstructions hair follicle lanceolate complex, Meissner corpuscle, Pacinian corpuscle subcellular distribution within them. all three organs, restricted sensory...
Here, we present the first analysis of connectome a small volume
Neural activity is increasingly recognized as a critical regulator of cancer growth. In the brain, neuronal robustly influences glioma growth both through paracrine mechanisms and electrochemical integration malignant cells into neural circuitry via neuron-to-glioma synapses, while perisynaptic neurotransmitter signaling drives breast brain metastasis Outside CNS, innervation tumors such prostate, breast, pancreatic gastrointestinal cancers by peripheral nerves similarly regulates...
Connectomics is fundamental in propelling our understanding of the nervous system's organization, unearthing cells and wiring diagrams reconstructed from volume electron microscopy (EM) datasets. Such reconstructions, on one hand, have benefited ever more precise automatic segmentation methods, which leverage sophisticated deep learning architectures advanced machine algorithms. On other field neuroscience at large, image processing particular, has manifested a need for user-friendly open...
Specialized mechanosensory end organs within mammalian skin-hair follicle-associated lanceolate complexes, Meissner corpuscles, and Pacinian corpuscles-enable our perception of light, dynamic touch 1 . In each these organs, fast-conducting mechanically sensitive neurons, called Aβ low-threshold mechanoreceptors (Aβ LTMRs), associate with resident glial cells, known as terminal Schwann cells (TSCs) or lamellar to form complex axon ending structures. Lanceolate-forming corpuscle-innervating...
Connectomics is fundamental in propelling our understanding of the nervous system’s organization, unearthing cells and wiring diagrams reconstructed from volume electron microscopy (EM) datasets. Such reconstructions, on one hand, have benefited ever more precise automatic segmentation methods, which leverage sophisticated deep learning architectures advanced machine algorithms. On other field neuroscience at large, image processing particular, has manifested a need for user-friendly open...
Abstract In mammals, the connections between motor neurons and muscle fibers profoundly reorganize in early postnatal period. To better understand this synaptic rewiring we traced out all connectivity muscles at successive ages mouse using serial section scanning electron microscopy a birth Brainbow-based XFP-based fluorescent reconstructions neonatal older respectively. Our data indicate that axons prune about 85% of their branches first two weeks life, while much pruning leaves...
Abstract Neural activity is increasingly recognized as a crucial regulator of cancer growth. In the brain, neuronal robustly influences glioma growth both through paracrine mechanisms and electrochemical integration malignant cells into neural circuitry via neuron-to-glioma synapses. Outside CNS, innervation tumors such prostate, breast, pancreatic, gastrointestinal cancers by peripheral nerves similarly regulates progression. However, extent to which nervous system lung progression, either...
Summary We present the first analysis of connectome vertical lobe (VL) Octopus vulgaris , a brain structure mediating acquisition long-term memory in this behaviorally advanced mollusk. Serial section electron microscopy revealed new types interneurons, cellular components extensive modulatory systems and multiple synaptic motifs. The sensory input to VL is conveyed via ~1,800,000 axons that sparsely innervate two parallel interconnected feedforward networks formed by amacrine interneurons...