A5018920924- Aquatic Ecosystems and Phytoplankton Dynamics
- Marine and coastal ecosystems
- Biocrusts and Microbial Ecology
- Neonatal Respiratory Health Research
- Mesenchymal stem cell research
- Marine Toxins and Detection Methods
- Retinal Diseases and Treatments
- Cardiovascular Issues in Pregnancy
- Chemical Analysis and Environmental Impact
- Tissue Engineering and Regenerative Medicine
- Chromosomal and Genetic Variations
- Evolution and Genetic Dynamics
- Atmospheric chemistry and aerosols
- Macrophage Migration Inhibitory Factor
- Cardiac Structural Anomalies and Repair
- Algal biology and biofuel production
- Glaucoma and retinal disorders
- Cancer, Hypoxia, and Metabolism
- Per- and polyfluoroalkyl substances research
- Extraction and Separation Processes
- Cancer and biochemical research
- Retinal Imaging and Analysis
- Retinopathy of Prematurity Studies
- Adrenal and Paraganglionic Tumors
- Microtubule and mitosis dynamics
University of Technology Sydney
2022-2023
UNSW Sydney
2012-2020
Woolcock Institute of Medical Research
2020
Birmingham Women's Hospital
2013
The University of Sydney
2012
Bristol Eye Hospital
2008
University of Bristol
2006-2008
To determine whether single nucleotide polymorphisms (SNPs) in the vascular endothelial growth factor (VEGF) gene are associated with severity of diabetic retinopathy.A case-control study was conducted which 45 individuals type 1 or 2 diabetes proliferative retinopathy (PDR) and 61 without (DWR) were genotyped for 14 SNPs VEGF promoter gene.Three SNP genotypes, -160C, -152A (rs13207351), -116A (rs1570360), showed significant independent associations PDR, as well minihaplotype CAA (P =...
Pheochromocytomas and paragangliomas are notable for a high frequency of inherited cases, many which present as apparently sporadic tumors.The objective this study was to establish comprehensive next generation sequencing (NGS)-based strategy the diagnosis patients with pheochromocytoma paraganglioma by testing simultaneously mutations in MAX, RET, SDHA, SDHB, SDHC, SDHD, SDHAF2, TMEM127, VHL.After methodology assay designed established, it validated on DNA samples known genotype then were...
The hepatotoxin microcystin (MCYST) is produced by a variety of freshwater cyanobacterial species, including Microcystis aeruginosa Interestingly, MCYST-producing M. strains have been shown to outcompete their nontoxic counterparts under iron-limiting conditions. However, the reasons for this are unclear. Here we examined proteomic response PCC 7806 continuous cultures different iron and growth regimes. Iron limitation was correlated with global reduction in levels proteins associated energy...
Photochemical reduction of iron and uptake by Microcystis were investigated in a freshwater medium (pH 8) containing range calcium (Ca) magnesium (Mg) ion concentrations (0.002–20 mM). In the chelator ethylenediaminetetraacetic acid (EDTA), 50-fold increases net photochemical formation rates unchelated ferrous (Fe(II)′) observed as concentration or metal (Me) was increased to exceed EDTA. Kinetic modeling transformation processes indicated that facilitated Fe(II)′ is attributed Me-promoted...
Abstract Background Chronic obstructive pulmonary disease (COPD) is characterized by irreversible lung tissue damage. Novel regenerative strategies are urgently awaited. Cultured mesenchymal stem/stromal cells (MSCs) have shown promising results in experimental models of COPD, but differences between sources may impact on their potential use therapeutic patients. Aim To assess the transcriptome lung-derived MSCs (LMSCs), bone marrow-derived (BM-MSC) and adipose-derived (AD-MSCs) from COPD...
Peripartum cardiomyopathy (PPCM) is a rare form of acute onset heart failure that presents in otherwise healthy pregnant women around the time delivery. While most these respond to early intervention, about 20% progress end-stage symptomatically resembles dilated (DCM). In this study, we examined two independent RNAseq datasets from left ventricle PPCM patients and compared gene expression profiles female DCM non-failing donors. Differential expression, enrichment analysis cellular...
The cyanobacterium Raphidiopsis raciborskii is of environmental and social concern in view its toxicity, bloom-forming characteristics increasingly widespread occurrence. However, while availability macronutrients micronutrients such as N Fe are critically important for the growth metabolism this organism, physiological response toxic non-toxic strains R. to varying availabilities remains unclear. By determining parameters a function availability, we demonstrate that N2 -fixing activity...
Raphidiopsis raciborskii is an invasive bloom-forming cyanobacteria with the flexibility to utilize atmospheric and fixed nitrogen. Since nitrogen-fixation has a high requirement for iron as ezyme cofactor, we hypothesize that availability would determine success of species under nitrogen-fixing conditions. This study compares proteomic response cylindrospermopsin-producing non-toxic strains R. racibroskii reduced concentrations, conditions, examine any strain-specific adaptations might...
Inhalation of coal dusts can invoke tissue damage and proinflammatory effects in the lungs which ultimately lead to disease known as Coal Workers' Pneumoconiosis (CWP). It is unknown if this related amount iron silica found different coals. <b>Methods:</b> We used X-ray Fluorescence combustion techniques determine chemical composition coals from 10 mines. Cytotoxicity was assessed by lactate dehydrogenase (LDH) release cells at 2, 6 24 hours. Human alveolar (A549) bronchial (Calu-3)...
Abstract Background : Chronic obstructive pulmonary disease (COPD) is characterized by irreversible lung tissue damage. Novel regenerative strategies are urgently awaited. Cultured mesenchymal stem/stromal cells (MSCs) have shown promising results in experimental models of COPD, but differences between sources may impact on their potential use therapeutic patients. Aim: To assess the transcriptome lung-derived MSCs (LMSCs), bone marrow-derived (BM-MSC) and adipose-derived (AD-MSCs) from COPD...