The relationship of plasma calcium levels to changes in specific gravity, total protein, and albumin induced by venous stasis was investigated. Factors were derived for adjusting results offset the effects variation protein concentration thus make them increased discriminatory value clinician. validity an existing gravity correction has been substantiated, but a more exact adjustment 0.23 mg/100 ml every 0.001 change is proposed. We recommend automated laboratories that factor based on be...

Hypoxia inducible factor (HIF) is a heterodimeric transcription composed of an oxygen-regulated α subunit and constitutively expressed β that serves as the master regulator cellular response to low oxygen concentrations. The HIF senses responds hypoxia by significantly altering reprogramming cells enable adaptation hypoxic microenvironment. Given central role played in survival growth tumors hypoxia, inhibition this potential therapeutic approach for treating variety cancers. Here, we report...

To determine whether single nucleotide polymorphisms (SNPs) in the vascular endothelial growth factor (VEGF) gene are associated with severity of diabetic retinopathy.A case-control study was conducted which 45 individuals type 1 or 2 diabetes proliferative retinopathy (PDR) and 61 without (DWR) were genotyped for 14 SNPs VEGF promoter gene.Three SNP genotypes, -160C, -152A (rs13207351), -116A (rs1570360), showed significant independent associations PDR, as well minihaplotype CAA (P =...

<h3>Background</h3> The UK Newborn Screening Programme Centre recommends that a blood spot thyroid stimulating hormone (TSH) cut-off of 10 mU/l is used to detect congenital hypothyroidism (CHT). As the value varies from 5 mU/l, we examined implications altering this threshold. <h3>Methods</h3> Our regional TSH 6 mU/l. Positive or suspected cases were defined as &gt;6 throughout study period (1 April 2005 1 March 2007). All term infants (&gt;35 weeks) whose first was 6–20 had second measured....

Equine pituitary pars intermedia dysfunction (PPID) is a common and serious condition that gives rise to Cushing's disease. In the older horse, it results in hyperadrenocorticism disrupted energy metabolism, severity of which varies with time year. To gain insight into mechanism its pathogenesis, 24-h profiles for peripheral plasma melatonin, serotonin, dopamine cortisol concentrations were determined at winter summer solstices, autumn spring equinoxes six horses diagnosed disease matched...

SUMMARY Long‐acting somatostatin analogues may be of benefit in certain hypersecretory endocrine and gastrointestinal disorders. The 24 h hormonal metabolic profiles six normal male subjects receiving a twice daily subcutaneous injection one such analogue SMS 201–995, 50 μg, has been compared to that obtained following placebo injection. Spontaneous daytime peaks GH secretion were delayed until 1400 201–995 but nocturnal total unaffected. rise thyrotrophin was abolished by thyroid function...

<h3>Background:</h3> Revised UK neonatal screening guidelines recommend that a second blood sample for assay of thyroid stimulating hormone (TSH) be taken when preterm infants reach postmenstrual age 36 weeks. <h3>Objective:</h3> To examine the results regional programme to see whether rise in TSH concentration was observed some between first around 5 days after delivery and at <h3>Methods:</h3> Whole-blood concentrations born over 2-year period (April 2005 March 2007) were assessed, number...

SUMMARY The interaction between the inhibitory effect on growth hormone secretion of a 75 g oral glucose load and stimulatory human pancreatic releasing factor 1–44 (hpGRF 1–44, 10 μg i.v.) has been studied in six normal subjects. hpGRF alone induced rise concentrations (maximum mean ± SEM, 16–5 1.7 mU/1 15 min after injection) while levels were suppressed by (&amp; &lt; 1 ‐5 from 45 to 135 ingestion). When was injected 60 glucose, response attenuated (maximum, 6.7±1.4 at min, P&lt;005)....

High altitude exposure normally leads to a marked natriuresis and diuresis. Acute mountain sickness is often associated with fluid retention, which an elevated cortisol may contribute. Most investigators report rise in resting ascent, but little data exist regarding the response day trekking. We therefore measured salivary during ascent >5 000 m cohort of between 42–45 subjects following 6-h trek (samples taken 15:30–16:30 h) 15–20 at rest (morning samples 08:00–09:00 h). Morning [nmol/l,...

Abstract Renal Fanconi syndrome (RFS) is a generalised disorder of the proximal convoluted tubule. Many genes have been associated with RFS including those that cause systemic disorders such as cystinosis, well isolated RFS. We discuss case 10‐year‐old female who presented leg pain and raised creatinine on screening blood test. Her mother has required kidney transplant in her thirties. Further investigations confirmed daughter. Exome sequencing was performed affected mother, child,...

SUMMARY Cell culture methods were used to assess whether human pituitary adenomas secreting GH and associated with clinical acromegaly also secreted the structurally unrelated glycoprotein hormone α‐subunit. Thirty‐two tumours, together peri‐adenomatous tissue from two of them three normal pituitaries studied. Anterior hormones measured by radioimmunoassay included PRL, TSH, LH, FSH, ACTH, as well Normal tissues all assayed. All 32 tumours ranging 241 5556 ng/2 × 10 5 cells/24 h 12 (37·5%)...

SUMMARY The growth hormone (GH) response of seven obese subjects to a 4 h continuous infusion human pancreatic GH‐releasing factor, 0·3 μg/kg/h, has been compared with that obtained in sex and age matched controls. pattern was normal the but peak GH levels (mean ± SEM: 13·8 1·9 30·9 4·7 mU/l, P &lt; 0·01) integrated 27·1 3·6 62·0 9·7 mU/l/h, were reduced subjects. There negative correlation between percentage ideal body weight ( r =−0·80, 0·05), no significant somatomedin‐C =+ 0·72; = 0·07)....

Growth hormone (GH) is important in diabetes view of its anti-insulin actions and relation to the long-term complications disease. The suppression GH secretion diabetics has theoretical possible therapeutic interest. Native somatostatin multiple actions, including inhibition insulin, glucagon, thyroid-stimulating (TSH), various gut hormones. It also inhibitory effects on gastrointestinal motility, exocrine secretion, nutrient absorption, splanchnic blood flow. Its use limited by a duration...

The effect of GH-releasing factor(1-44)(GRF) alone, or together with somatostatin (SRIF), dopamine (DA), vasoactive intestinal peptide (VIP) cycloheximide was studied in a total ten human somatotrophinomas using static cell culture system. Growth hormone-releasing factor (2.0 X 10(-8) mol/l) significantly (P less than 0.05) stimulated GH release from nine out tumours over 4-h incubations, and dose-related 10(-10) -2.0 observed five thus studied. Repeated GRF mol/l)-mediated seen during 96%...

Alternative splicing of the last exon (exon 8) vascular endothelial growth factor (VEGF) pre-mRNA is a key element in balance pro- and anti-angiogenic VEGF isoforms exudative age-related macular degeneration (exAMD) proliferative diabetic retinopathy (PDR). Three factors, SRp40, ASF/SF2, SRp55 are predicted to control alternative by binding exonic splice enhancers (ESE) 8. This pilot study examines whether there an association between angiogenic eye disease polymorphisms, sequence variations...

The importance of magnetic cleanliness and inflight compensation to account for fluctuations in field is a recognized concern within the space industry. Their effects must be considered, minimized, where necessary compensated throughout development any spacecraft, their subsystems, while flight. This just as true context laser interferometer antenna pathfinder mission, sensitive gravitational wave telemetry systems are vulnerable disturbances. In collaboration with Science Technology...

Journal Article Hypoadrenalism in patients with pulmonary tuberculosis Tanzania: an undiagnosed complication? Get access F. Mugusi, Mugusi 1Department of Medicine, Muhimbili Medical Centre, University Dar es Salaam, Tanzania Search for other works by this author on: Oxford Academic PubMed Google Scholar A.B.M. Swai, Swai S.J. Turner, Turner 2Supra-Regional Assay Laboratory, Royal Victoria Infirmary, Newcastle upon Tyne, UK K.G.M.M. Alberti, Alberti 3Department Address correspondence:...

The interaction between the stimulatory effects of hpGRF 1-44 and inhibitory somatostatin on GH release have been investigated in six normal male subjects receiving continuous 4 h infusions these peptides alone combination. 0.3 microgram/kg/h produced a peak response 27.0 +/- 7.6 mU/l (mean SEM). Somatostatin 1.0 markedly inhibited to with mean levels less than 4.0 during infusion, though rebound rise 26.1 9.0 was observed at end infusion period. 0.2 lesser degree (peak 11.7 2.5 mU/l)...

SUMMARY The 24‐h hormonal and metabolic profiles obtained in five non‐insulin‐dependent diabetics receiving twice daily s.c. injections of the long‐acting somatostatin analogue SMS 201–995 (50 μg) have been compared with those following placebo injection. Injections were given 30 min before breakfast evening meal. GH secretion was not suppressed by administered this manner. Despite suppression serum insulin levels meal, blood glucose similar during two study periods no evidence worsening...

Fifty nine children of short stature exercised for 10 minutes on a non-motorised treadmill. In 49 growth hormone concentration greater than 15 mU/l was reached, effectively excluding deficiency. the failed to reach mU/l; deficiency confirmed in seven by subsequent insulin tolerance test. The optimal time blood sampling five after end exercise. It possible use test very young and children.