A5027416493- Laser Design and Applications
- Laser-Plasma Interactions and Diagnostics
- Laser-induced spectroscopy and plasma
- Fish Ecology and Management Studies
- Laser-Matter Interactions and Applications
- Fish Biology and Ecology Studies
- Atomic and Molecular Physics
- Hepatitis C virus research
- Solid State Laser Technologies
- Liver Disease Diagnosis and Treatment
- Genetic diversity and population structure
- Fish biology, ecology, and behavior
- High-pressure geophysics and materials
- Laser Material Processing Techniques
- Lipoproteins and Cardiovascular Health
- Systemic Lupus Erythematosus Research
- Advanced X-ray Imaging Techniques
- Identification and Quantification in Food
- Particle accelerators and beam dynamics
- Parasite Biology and Host Interactions
- Nuclear Physics and Applications
- Particle Accelerators and Free-Electron Lasers
- Aquatic Invertebrate Ecology and Behavior
- Advanced Fiber Laser Technologies
- X-ray Spectroscopy and Fluorescence Analysis
Rutherford Appleton Laboratory
2009-2021
Tennessee Temple University
2013-2021
University of Strathclyde
2009-2020
Newcastle upon Tyne Hospitals NHS Foundation Trust
2009-2018
Royal Victoria Infirmary
2008-2016
Saint Louis University
2003-2016
Central Laser Facility
2003-2013
Inova Health System
2013
Science and Technology Facilities Council
2013
California Academy of Sciences
2007-2012
Statins are widely used lipid-lowering drugs that effective in reducing cardiovascular disease risk. Although they generally well tolerated, can cause muscle toxicity, which lead to severe rhabdomyolysis. Research this area has been hampered some extent by the lack of standardized nomenclature and phenotypic definitions. We have numerical descriptive classifications developed an algorithm define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, necrotizing...
Identifying Crohn's disease recurrence in symptomatic patients after ileocaecal resection is difficult. The aim of this study was to evaluate faecal concentrations granulocyte degradation products setting.A postoperative cohort 13 followed prospectively for 1 year with regular calprotectin (FC) and lactoferrin (FL) measurements. A second (median 24 months resection) 104 provided a single stool sample. Faecal measurements were compared symptom diaries, the Harvey Bradshaw Index, endoscopic...
To evaluate the monophyly of Cottus and to identify species groups within genus we generated a data set 1914 base pairs mitochondrial DNA (cytochrome b ATPase 8 6) for 87 individuals representing 36 42 currently recognized genus. Both parsimony Bayesian analyses consistently supported non-monophyly with respect Baikalian sculpins Leptocottus. Analyses also recognition five clades Cottus. These are referred herein as Cottopsis, Uranidea, Baikalian, Cottus, Cephalocottus clades. encompass all...
Hepatitis C virus (HCV) co-opts very-low-density lipoprotein (VLDL) pathways for replication, secretion and entry into hepatocytes associates with apolipoprotein B (apoB) in plasma. Each VLDL contains apoB-100 variable amounts of apolipoproteins E C, cholesterol triglycerides.To determine whether baseline lipid levels predicted treatment outcome.Retrospective analysis was performed 250 chronic hepatitis (CHC) patients who had received anti-viral agents interferon-alpha ribavirin; 165 a...
High altitude exposure normally leads to a marked natriuresis and diuresis. Acute mountain sickness is often associated with fluid retention, which an elevated cortisol may contribute. Most investigators report rise in resting ascent, but little data exist regarding the response day trekking. We therefore measured salivary during ascent >5 000 m cohort of between 42–45 subjects following 6-h trek (samples taken 15:30–16:30 h) 15–20 at rest (morning samples 08:00–09:00 h). Morning [nmol/l,...
Aim Geomorphic evolution of river basins can shape the structure and diversity aquatic communities, but understanding biological significance basin be challenging in semi-arid regions with ephemeral or endorheic conditions complex drainage configurations such as Sierra Madre Occidental (SMO) North America. In this study, we characterized range-wide patterns genetic variation Mexican stoneroller (Campostoma ornatum) to infer how orogenic erosional influences on connectivity have given rise...
High-intensity laser–solid interactions generate relativistic electrons, as well high-energy (multi-MeV) ions and x-rays. The directionality, spectra total number of electrons that escape a target-foil is dependent on the absorption, transport rear-side sheath conditions. Measuring escaping target will aid in improving our understanding these absorption processes rear-surface fields retard accelerate via normal acceleration (TNSA) mechanism. A comprehensive Geant4 study was performed to help...
Next generation intense, short-pulse laser facilities require new high repetition rate diagnostics for the detection of ionizing radiation. We have designed a scintillator-based ion beam profiler capable measuring transverse profile number discrete energy ranges. The optical response and emission characteristics four common plastic scintillators has been investigated range proton energies fluxes. scintillator light output (for 1 MeV > E<sub>p</sub> < 28 MeV) was found to non-linear...
Campostoma are ubiquitous across North America, yet relationships among members of the genus poorly understood. Here we present phylogenetic hypotheses based on analyses DNA sequence data from mitochondrial cytochrome b gene. All consistently recovered nine clades comparable topological structure. Differentiation did not follow currently accepted taxonomic boundaries, and was consistent with previously hypothesized recognized species subspecies. Rather, corresponded to broad geographic...
Abstract A high power laser was used to accelerate electrons in a laser-driven wakefield accelerator. The energy were then generate an x-ray beam by passing them through converter target. This bremsstrahlung source characterised and perform penetrative imaging of industrially relevant samples. photon spectrum had critical excess 100 MeV size smaller than the resolution diagnostic ( <?CDATA $\lesssim$?> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll">...
An introduced population of Etheostoma blennioides (greenside darter) in the Susquehanna River drainage has rapidly expanded its range since discovery late 1960s. Geochronology collection data provides evidence for explosive dispersal and long-range movement patterns. We discuss current status distribution E. drainage, suggest that other Mid-Atlantic Slope drainages with low native-darter diversity are at risk similar colonization events. Although long-term effect these invasive populations...
To appraise conservation status of the Yaqui catfish Ictalurus pricei, we reviewed literature and unpublished records on a captive stock, examined voucher specimens at museums, re-sampled historical localities in Yaqui, Mayo, Fuerte river basins, surveyed rivers further south. A total 72 native was collected Fuerte, Sinaloa, Culiacán, San Lorenzo basins. No Mayo Basin. Distribution appears restricted to all which now harbor nonnative blue (I. furcatus) channel punctatus) catfishes. The black...
Insights into the generation of diversity in both plants and animals have relied heavily on studying speciation adaptive radiations. Russia's Lake Baikal has facilitated a putative radiation cottid fishes (sculpins), some which are highly specialized to inhabit novel niches created by lake's unique geology ecology. Here, we test evolutionary relationships morphological adaptation piece this radiation: genus, Cottocomephorus, morphologically derived benthopelagic genus three described...
Three new species of Percina are described from upland drainages the Mobile Basin. Two three narrowly distributed: P. kusha, Bridled Darter, is currently known only Conasauga River drainage in Georgia and Tennessee Etowah Georgia, both tributaries Coosa River, sipsi, Bankhead which restricted to Sipsey Fork Black Warrior northwestern Alabama. The third species, smithvanizi, Muscadine occurs above Fall Line Tallapoosa eastern Alabama western Georgia. In a molecular analysis using...
Astra Gemini is a dual-beam petawatt Ti:sapphire laser at the Rutherford Appleton Laboratory in U.K. We report measurements characterising beam quality, pulse energy, and duration of first line.
We present details of a refurbishment and development programme that we have undertaken on the Vulcan Nd:Glass laser system to improve delivery its two target areas. For area petawatt in addition replacing gratings compressor chamber installed new diagnostic line for improved pulse length measurement commissioned high energy seed contrast. In west replaced grating short focal spot quality. Both areas been re-commissioned their parameters measured showing has below 500fs focused size 4μm beam...
With the development of high-intensity and high-repetition rate laser systems, it has become crucial to be able detect characterize in real time high-energy byproducts (mainly electrons photons) laser-generated plasma. A novel multi-purpose scintillator-based electromagnetic calorimeter focused on particle photon measurements capable working a shot-by-shot basis at is being developed ELI Beamlines center. Preliminary tests this device under electron irradiation from conventional laser-driven...
Cottus caeruleomentum (Blue Ridge Sculpin) is described from the Elk, Susquehanna, Bush, Patapsco, Patuxent, Potomac, Nanticoke, James, and Roanoke drainages of middle Atlantic eastern United States. The new species a member bairdi group with following characters: sexual dimorphism in breeding features, two-spotted first dorsal fin, chin uniformly pigmented, saddles moderate to wide, incomplete lateral line, preopercular spines slight moderate, palatine teeth weak postpectoral prickling...
Percina burtoni (Percidae: subgenus Percina), Blotchside Logperch, historically occupied much of the Tennessee and Cumberland River drainages, but is now restricted to highly fragmented populations where they occur at low densities. Widespread impoundment subsequent river alteration over past 60 years has eliminated many reduced potential for dispersal gene flow between extant populations. We examined genetic variation two mitochondrial genes, cytochrome b ND2, from 74 individuals in ten...