A5008266573- High Altitude and Hypoxia
- Neuroscience of respiration and sleep
- Cardiac Arrest and Resuscitation
- Heart Rate Variability and Autonomic Control
- Cardiac, Anesthesia and Surgical Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Travel-related health issues
- Cardiovascular and Diving-Related Complications
- Trauma and Emergency Care Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Respiratory Support and Mechanisms
- Cardiovascular Effects of Exercise
- Disaster Response and Management
- Adipose Tissue and Metabolism
- Cardiac Valve Diseases and Treatments
- Hemodynamic Monitoring and Therapy
- Cardiovascular and exercise physiology
- Sepsis Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Anesthesia and Neurotoxicity Research
- Cardiovascular Syncope and Autonomic Disorders
- Aortic Disease and Treatment Approaches
- Climate Change and Health Impacts
- Trauma Management and Diagnosis
James Cook University Hospital
2012-2022
Medical Defence Union
2011-2022
Leeds Beckett University
2014-2022
South Tees Hospitals NHS Foundation Trust
2017-2022
Royal Victoria Hospital
2020
University of Ulster
2020
Queen Elizabeth Hospital Birmingham
2020
Royal Navy
2007-2019
Defence Equipment and Support
2013-2019
Tees, Esk and Wear Valleys NHS Foundation Trust
2018
Boos, Christopher John, David R. Woods, Andrea Varias, Sheryl Biscocho, Peter Heseltine, and Adrian J. Mellor. High altitude acute mountain sickness changes in circulating endothelin-1, interleukin-6, interleukin-17a. Alt Med Biol. 17:25–31, 2016.—Introduction: Hypoxia induces an inflammatory response, which is enhanced by exercise. (HA) leads to endothelial activation may be proinflammatory. The relationship between activation, inflammation, (AMS) its severity has never been examined....
Military trauma produces predominantly blast and fragmentation injury, commonly resulting in haemorrhagic shock. Injury patterns to limbs are such that the conventional sites for venous cannulation may be unsuitable. The EZ-IO® (Vidacare®, San Antonio) system is one of a number novel products designed intraosseous (IO) access adults or children. In three months combat casualty care Helmand Province, Afghanistan, UK Defence Medical Services used emergency vascular on 26 patients (16 adults;...
Whilst the link between physical factors and risk of high altitude (HA)-related illness acute mountain sickness (AMS) have been extensively explored, influence psychological has less well examined. In this study we aimed to investigate relationship 'anxiety AMS during a progressive ascent very HA.Eighty health adults were assessed at baseline (848m) over 9 consecutive altitudes trek 5140m. HA-related symptoms (Lake Louise [LLS] AMS-C Scores) state anxiety (State-Trait-Anxiety-Score [STAI...
To investigate whether there is a differential response at rest and following exercise to conditions of genuine high altitude (GHA), normobaric hypoxia (NH), hypobaric (HH), normoxia (NN).Markers sympathoadrenal adrenocortical function [plasma normetanephrine (PNORMET), metanephrine (PMET), cortisol], myocardial injury [highly sensitive cardiac troponin T (hscTnT)], [N-terminal brain natriuretic peptide (NT-proBNP)] were evaluated with under NN, 3375 m in the Alps (GHA) equivalent simulated...
Background There has been considerable debate as to whether different modalities of simulated hypoxia induce similar cardiac responses. Materials and Methods This was a prospective observational study 14 healthy subjects aged 22–35 years. Echocardiography performed at rest 15 120 minutes following two hours exercise under normobaric normoxia (NN) PiO2 genuine high altitude (GHA) 3,375m, (NH) hypobaric (HH) simulate the equivalent hypoxic stimulus GHA. Results All completed experiment GHA, 11...
Background: intravenous (IV) drugs are administered widely and under-dosing can result in therapy failure. The aim of this study was to quantify frequency, volume dose drug discarded within administration sets the clinical setting. Methods: residual for 24 different measured under controlled conditions a laboratory. Clinical assessment current practice regarding post-infusion flushing occurred 6 departments one teaching hospital UK over 7 days. Details last infused, (concentration, diluent...
High altitude exposure normally leads to a marked natriuresis and diuresis. Acute mountain sickness is often associated with fluid retention, which an elevated cortisol may contribute. Most investigators report rise in resting ascent, but little data exist regarding the response day trekking. We therefore measured salivary during ascent >5 000 m cohort of between 42–45 subjects following 6-h trek (samples taken 15:30–16:30 h) 15–20 at rest (morning samples 08:00–09:00 h). Morning [nmol/l,...
Boos, Christopher J., Pete Hodkinson, Adrian Mellor, Nicholas P. Green, and David R. Woods. High Alt. Med. Biol. 13:105–111.—This study investigated, for the first time, effects of simulated high altitude, following acute hypobaric hypoxia (HH), on simultaneous assessment large artery stiffness endothelial function its inter-relationship to left ventricular (LV) diastolic function, pulmonary systolic pressure (PASP), estimated PA vascular resistance (PVR). Ten healthy subjects were studied...
There is evidence suggesting that high altitude (HA) exposure leads to a fall in heart rate variability (HRV) linked the development of acute mountain sickness (AMS). The effects sex on changes HRV at HA and its relationship AMS are unknown.HRV (5-min single-lead ECG) was measured 63 healthy adults (41 men 22 women) 18-56 yr age sea level (SL) during trek 3619, 4600, 5140 m, respectively. main (SL, 3619 4600 m) (men vs their potential interaction were assessed using factorial...
To examine the response of brain natriuretic peptide (BNP) and NT-proBNP to high altitude (HA) both at rest following exercise.We measured BNP Lake Louise (LL) acute mountain sickness (AMS) scores in 20 subjects Kathmandu (Kat; 1300 m), exercise 4270 5150 m.BNP (pg ml(-1) , mean ± SEM) rose significantly from Kat (9.2 2 36.9 6.6, respectively) arrival m after (16.6 4 152 56.1, P=0.008 P<0.001, remained elevated next morning (28.9 9 207.4 65.1, P = 0.004 P<0.001 respectively). At 5150,...
Mellor, Adrian, Christopher Boos, David Holdsworth, Joe Begley, Hall, Andrew Lumley, Anne Burnett, Amanda Hawkins, John O'Hara, Stephen Ball, and Woods. Cardiac biomarkers at high altitude. High Alt Med Biol 15:452–458, 2014.—Background: Classically, such as the natriuretic peptides (NPs) BNP/NT-proBNP are associated with diagnosis of heart failure hs-cTnT acute coronary syndromes. NPs also elevated in pulmonary hypertension. artery systolic pressure (PASP) is a key feature altitude edema...
This study compared the effects of coingesting glucose and fructose on exogenous endogenous substrate oxidation during prolonged exercise at altitude sea level, in men. Seven male British military personnel completed two bouts cycling same relative workload (55% Wmax) for 120 min acute exposure to (3375 m) level (~113 m). In each trial, participants ingested 1.2 g·min−1 (enriched with 13C glucose) 0.6 fructose) directly before every 15 exercise. Indirect calorimetry isotope ratio mass...
Abstract. The impact of lead shot on soils and crops was examined at a clay pigeon shooting site in northern England. Topsoil cores were collected along 300 m transect from the range, numbers pellets per soil core, total ‘plant‐available’(0.5 acetic acid extractable) concentrations, organic matter content, pH cation exchange capacity determined. number oilseed rape plants their stem diameters recorded 1 2 quadrats placed sampling locations. Total ‘plant‐available’ concentrations most but...
There is a widely held belief that strenuous exercise should be avoided on arrival at high altitude (HA) and during acclimatization. Data from chamber studies are contradictory the usually of short duration, therefore differing "real world."We studied 48 trekkers 10-d ascent to 16,827 ft (5129 m) in Cordillera Real area Bolivia. Borg Rating Perceived Exertion (RPE) scores were recorded for hardest perceived exertion day after ascents 12,576, 14,600, (3833, 4450, 5129 m). Heart rate, Spo2,...
Abstract Purpose Circulating acylated ghrelin concentrations are associated with altitude-induced anorexia in laboratory environments, but have never been measured at terrestrial altitude. This study examined time course changes appetite, energy intake, body composition, and constituents during a high-altitude trek. Methods Twelve participants [age: 28(4) years, BMI 23.0(2.1) kg m −2 ] completed 14-day trek the Himalayas. Energy appetite perceptions, circulating acylated, des-acylated, total...
Boos, Christopher John, Adrian Mellor, John Paul O'Hara, Costas Tsakirides, and David Richard Woods. The effects of sex on cardiopulmonary responses to acute normobaric hypoxia. High Alt Med Biol. 17:108-115, 2016.-Acute hypoxia leads a number recognized changes in function, including increase pulmonary artery systolic pressure. However, the comparative between men women have been barely explored.Fourteen young healthy adult Caucasian subjects were studied at sea-level rest then after...
Exposure to high altitude has been shown enhance both glucose and lipid utilization depending on experimental protocol. In addition, low blood levels have reported at altitude. We hypothesized that gradual ascent results in changes healthy young adults.Twenty-five adult volunteers, split into two teams, took part the British Services Dhaulagiri Medical Research Expedition completing 14 d of trekking around circuit Nepal reaching a peak 5300 m day 11 trek. Participants wore blinded continuous...
Summary Heart rate variability ( HRV ) is a useful index of autonomic function and has been linked to the development high altitude HA related illness. However, its assessment at undermined by relative expense limited portability traditional devices which have mandated least minute heart recording. In this study, portable ithlete ™ system, uses 55 s recording, was compared with reference method utilizes 5 min electrocardiograph recording (CheckMyHeart ). The root mean squares successive R‐R...