A5077672453- Pharmacogenetics and Drug Metabolism
- Pharmaceutical studies and practices
- Lipoproteins and Cardiovascular Health
- Biosimilars and Bioanalytical Methods
- Hormonal Regulation and Hypertension
- Drug-Induced Adverse Reactions
- Cardiac electrophysiology and arrhythmias
- Kawasaki Disease and Coronary Complications
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Economics and Policy
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Statistical Methods in Clinical Trials
- Viral gastroenteritis research and epidemiology
- Inhalation and Respiratory Drug Delivery
- BRCA gene mutations in cancer
- Thermal Regulation in Medicine
- Atrial Fibrillation Management and Outcomes
- Viral Infections and Immunology Research
- Palliative Care and End-of-Life Issues
- Family and Disability Support Research
- Child Nutrition and Feeding Issues
- Health Sciences Research and Education
- Genomics and Rare Diseases
- Long-Term Effects of COVID-19
Aintree University Hospitals NHS Foundation Trust
2024-2025
University of Liverpool
2013-2025
Royal Liverpool University Hospital
2023
Royal Liverpool and Broadgreen University Hospital NHS Trust
2014-2019
Derbyshire Community Health Services NHS Foundation Trust
2012
Statins are widely used lipid-lowering drugs that effective in reducing cardiovascular disease risk. Although they generally well tolerated, can cause muscle toxicity, which lead to severe rhabdomyolysis. Research this area has been hampered some extent by the lack of standardized nomenclature and phenotypic definitions. We have numerical descriptive classifications developed an algorithm define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, necrotizing...
Warfarin is the most widely used oral anticoagulant worldwide, but it has a narrow therapeutic index which necessitates constant monitoring of anticoagulation response. Previous genome-wide studies have focused on identifying factors explaining variance in stable dose, not explored initial patient response to warfarin, and wider range clinical biochemical affecting both dosing with warfarin.A prospective cohort 711 patients starting warfarin was followed up for 6 months analyses focusing...
Warfarin is a widely used oral anticoagulant. Determining the correct dose required to maintain international normalised ratio (INR) within therapeutic range can be challenging. In previous trial, we showed that dosing algorithm incorporating point-of-care genotyping information ('POCT-GGD' approach) led improved anticoagulation control. To determine whether this approach could translate into clinical practice, undertook an implementation project using matched cohort design.At three clinics...
Abstract Background Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are life-threatening reactions that cause blistering of the skin mucous membranes. Survivors can experience long term physical psychological complications. The ‘My SJS Passport’ was co-produced by Patient Public Involvement group research team at Wolfson Centre for Personalised Medicine to improve care experiences survivors. Objectives aim study implement in a real-world setting evaluation those with...
In this prospective cohort study, we have undertaken a comprehensive evaluation of clinical parameters along with variation in 29 genes (including CYP2C9 and VKORC1) to identify factors determining interindividual variability warfarin response.
High-potency statin therapy is recommended in the secondary prevention of cardiovascular disease but discontinuation, dose reduction, switching, and/or nonadherence occur practice.To determine prevalence and predictors deviation from high-potency use early after a non-ST elevation acute coronary syndrome (NSTE-ACS) its association with subsequent major adverse events (MACE) all-cause mortality (ACM).A total 1005 patients UK-based prospective NSTE-ACS cohort study discharged on (atorvastatin...
Aim: Although several genetic and nongenetic factors are associated with warfarin dose, approximately 40% of variability remains unexplained. An as yet unexplored factor is medication adherence. Here, we investigate the influence adherence on response to pharmacogenetic analyses association. Patients & methods: A total 311 patients starting were followed-up prospectively, was measured at 1, 8 26 weeks. The association between tested, additional proportion in explained by assessed. Results:...
Research is part of the remit NHS and consequently many patients participate in research studies. Clinical nurses have a vital role research, since they care for who studies act as patient advocates during research. However, nursing students are rarely provided with an opportunity to undertake placement. They therefore limited understanding what being participant involves patients. This article describes type carried out trust northwest England, how placements were set up that beneficial...
Abstract Background Biobanking biospecimens and consent are common practice in paediatric research. We need to explore children young people’s (CYP) knowledge perspectives around the use of biobanking. This will ensure meaningful informed can be obtained improve current procedures. Methods designed a survey, co-production with CYP, collecting demographic data, views on biobanking, using three scenarios: 1) prospective consent, 2) deferred 3) reconsent assent at age capacity. The survey was...
Changing established clinical practices in healthcare systems, such as the UK National Health Service (NHS), can be a challenge.Introducing innovation into practice or disrupting pathways has potential to deliver more efficient and higher quality health service.However, with research findings typically taking around 17 years translate practice, NHS recognized need speed up innovation, highlighted long-term plan [1].The transformation of service delivery through requires clear for effective...
Autism is a neurodevelopmental condition affecting three main areas: social communication, interaction and restricted patterns of behaviour, interests activities. The Diagnostic Statistical Manual Mental Disorders, 4th edition (DSM IV) requires six or more clinical manifestations across the areas.1 In International Classification Disease, version 10 (ICD-10) childhood autism under umbrella heading ‘pervasive developmental disorders’. Here diagnosis includes same areas, which should be seen...
Background UK patients of all ages can contribute to the Medicines and Healthcare Regulatory Agency (MHRA) Yellow Card scheme (YCS), reporting suspected adverse drug reactions (ADRs). Children’s young people’s (CYPs) contribution to, awareness of, YCS is not known. Methods Suspected ADR reports received by MHRA from 01/01/2008 29/11/2018 were examined. Prospective data CYP parents in paediatric outpatients collected as part QUestionnaire study about Adverse Drug ReAcTions In Children...