A5059697200- Nuclear Physics and Applications
- Nuclear physics research studies
- Atomic and Molecular Physics
- Mass Spectrometry Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Particle accelerators and beam dynamics
- Quantum Chromodynamics and Particle Interactions
- Advanced Chemical Physics Studies
- Particle physics theoretical and experimental studies
- Nuclear reactor physics and engineering
- Radioactive element chemistry and processing
- Advanced X-ray Imaging Techniques
- Radioactive Decay and Measurement Techniques
- Nuclear Materials and Properties
- X-ray Spectroscopy and Fluorescence Analysis
- Crystallography and Radiation Phenomena
- Agriculture, Plant Science, Crop Management
- Radiation Therapy and Dosimetry
- Medical Imaging and Pathology Studies
- Ion-surface interactions and analysis
- Radioactive contamination and transfer
- Wheat and Barley Genetics and Pathology
- Analytical chemistry methods development
- Laser Design and Applications
TRIUMF
2015-2024
Simon Fraser University
2018-2024
University of Liverpool
2023
University of British Columbia
2020
Oregon State University
2013
Johannes Gutenberg University Mainz
2002-2012
Stanford Synchrotron Radiation Lightsource
1988
Stanford University
1988
SLAC National Accelerator Laboratory
1988
The shape of exotic even-mass 182–190Pb isotopes was probed by measurement optical isotope shifts providing mean square charge radii (δ⟨r2⟩). experiment carried out at the isolde (cern) on-line mass separator, using in-source laser spectroscopy. Small deviations from spherical droplet model are observed, but when compared to calculations, those explained high sensitivity δ⟨r2⟩ beyond mean-field correlations and small admixtures intruder configurations in ground state. data support...
Until recently, ground-state nuclear moments of the heaviest nuclei could only be inferred from spectroscopy, where model assumptions are required. Laser spectroscopy in combination with modern atomic structure calculations is now able to probe these directly, a comprehensive and nuclear-model-independent way. Here we report on unique access differential mean-square charge radii ^{252,253,254}No, therefore changes size shape. State-of-the-art density functional describe well region heavy...
One of the most important atomic properties governing an element's chemical behavior is energy required to remove its least-bound electron, referred as first ionization potential. For heaviest elements, this fundamental quantity strongly influenced by relativistic effects which lead unique properties. Laser spectroscopy on atom-at-a-time scale was developed and applied probe optical spectrum neutral nobelium near threshold. The potential determined here with a very high precision from...
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The atomic level structure of the element fermium was investigated for first time using a sample 2.7x10(10) atoms isotope 255Fm with half-life 20.1 h. were evaporated from filament and stored in argon buffer gas an optical cell. Atomic levels sought by method resonance ionization spectroscopy excimer-dye-laser combination. Two found at wave numbers (25 099.8+/-0.2) 111.8+/-0.2) cm(-1). Partial transition rates to 5f(12)7s(2) (3)H(e)(6) ground state have been determined their saturation...
Effective use of the decay chain in targeted internal radioimmunotherapy requires retention both and progeny isotopes at target site. Imaging-based pharmacokinetic tests these pharmaceuticals must therefore separately yet simultaneously image multiple that may not be colocalized despite being part same chain. This work presents feasibility studies demonstrating ability a microSPECT/CT scanner equipped with high energy collimator to two components chain: (218 keV) (440 keV). Image quality...
Modern experiments at isotope separator on-line (ISOL) facilities like ISAC TRIUMF often depend critically on the purity of delivered rare beams. Therefore, highly selective ion sources are essential. This article presents development and successful operation an guide laser source (IG-LIS) for production beams free isobaric contamination. Thermionic ions from hot ISOL target suppressed by electrostatic potential barrier, while neutral radio nuclides effusing out resonantly ionized radiation...
Actinium-225 (225Ac, t1/2 = 9.9 d) is a promising candidate radionuclide for use in targeted alpha therapy (TAT), though the currently limited global supply has hindered development of suitable Ac-chelating ligand and 225Ac-radiopharmaceuticals towards clinic. We at TRIUMF have leveraged our Isotope Separation On-Line (ISOL) facility to produce 225Ac resulting radioactivity screen number potential 225Ac-radiopharmaceutical compounds.MBq quantities parent radium-225 (225Ra, 14.8 were produced...
Terbium radioisotopes (149Tb, 152Tb, 155Tb, 161Tb) offer a unique class of radionuclides which encompass all four medicinally relevant nuclear decay modalities (α, β+, γ, β-/e-), and show high potential for the development element-matched theranostic radiopharmaceuticals. The goal this study was to design, synthesise, evaluate suitability crown-TATE as new peptide-conjugate radiolabelling [155Tb]Tb3+ [161Tb]Tb3+, assess imaging pharmacokinetic properties each radiotracer in tumour-bearing...
Truly table-top sized radiation sources based on compact laser-plasma accelerators require and strong focusing devices efficient short-period undulators. Complementing our recent theoretical work the feasibility of a FEL, we here present design successful experimental characterizations 5 mm period length undulator miniature quadrupole magnets with field gradients order $500\text{ }\text{ }\mathrm{T}/\mathrm{m}$.
TRIUMF has a long history of medical isotope production. For more than 40 years, the Life Sciences Division at produced isotopes for Positron Emission Tomography (PET) local hospitals. Recently, division taken on challenge to expand facility's repertoire imaging treatment. At smallest cyclotron with energy 13 MeV, radiometals are being in liquid target which is typically used PET This effort makes available early stage research and preclinical trials. beam 24 we produce 99mTc from 100Mo...
Superior bifunctional chelating ligands, which can sequester both α-emitting radionuclides (225Ac, 213Bi) and their diagnostic companions (155Tb, 111In), remain a formidable challenge to translating targeted alpha therapy, with complementary imaging, the clinic. H4noneupaX, ligand an unusual diametrically opposed arrangement of pendant donor groups, has been developed this end. H4noneunpaX preferentially complexes Ln3+ An3+ ions, forming thermodynamically stable (pLa = 17.8, pLu 21.3)...
At the ISAC facility at TRIUMF radioactive ions are produced by bombarding solid targets with up to 100 μA of 500 MeV protons. The reaction products have diffuse out hot target into an ion source. Normally, singly charged extracted. They can be transported either directly experiments or via ECR charge state breeder a post accelerator. Several different types sources used in order deliver large variety rare isotope beams. those surface sources, forced electron beam arc discharge (FEBIAD) and...
The application of quadrupole devices with high field gradients and small apertures requires precise control over higher order multipole components. We present a new scheme for performance tuning, which allows the illumination most device aperture because reduction Consequently, size can be minimized to match beam achieving up $500\text{ }\text{ }\mathrm{T}\text{ }{\mathrm{m}}^{\ensuremath{-}1}$ at good imaging quality. characterization method based on Hall probe measurement Fourier analysis...