A5065871298- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Amino Acid Enzymes and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- Anesthesia and Neurotoxicity Research
- Physiological and biochemical adaptations
- Neurobiology and Insect Physiology Research
- Wnt/β-catenin signaling in development and cancer
- Genetics, Aging, and Longevity in Model Organisms
- Receptor Mechanisms and Signaling
- S100 Proteins and Annexins
- Epigenetics and DNA Methylation
- Neurotransmitter Receptor Influence on Behavior
University of Miami
2022-2024
Neurological Surgery
2022-2024
Loyola University Chicago
2022
University of Florida
2018
The University of Texas at Tyler
2018
University of Tennessee at Knoxville
2018
Sewanee: The University of the South
2018
Pomona College
2018
Abstract Synaptic damage is one of the most prevalent pathophysiological responses to traumatic CNS injury and underlies much associated cognitive dysfunction; however, it poorly understood. The D‐amino acid, D‐serine, serves as primary co‐agonist at synaptic NMDA receptors (NDMARs) a critical mediator NMDAR‐dependent transmission plasticity. In physiological conditions, D‐serine produced released by neurons from enzymatic conversion L‐serine serine racemase (SRR). However, under...
SUMMARY Cognitive losses resulting from severe brain trauma have long been associated with the focal region of tissue damage, leading to devastating functional impairment. For decades, researchers focused on sequelae cellular alterations that exist within perilesional tissues; however, few clinical trials successful. Here, we employed a mouse injury model resulted in expansive synaptic damage regions outside injury. Our findings demonstrate results prolonged increase D-serine release...
Syndecan (Sdc) is a transmembrane heparan sulfate proteoglycan that plays crucial role in axon guidance and synapse formation during CNS development Drosophila melanogaster. To further examine the effect of syndecan on function, Sdc23 mutant D. melanogaster larvae were used to odor preference capacity for learning memory. A series olfaction assays both wild type performed characterize naive responses before adding training period identify associative learning. These results showed prefer...