A5032048203- Adenosine and Purinergic Signaling
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Reproductive System and Pregnancy
- Peptidase Inhibition and Analysis
- Cytomegalovirus and herpesvirus research
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Mesenchymal stem cell research
- Neonatal Respiratory Health Research
- Drug Transport and Resistance Mechanisms
- Immunotherapy and Immune Responses
- Viral-associated cancers and disorders
- Polyomavirus and related diseases
- Pregnancy and Medication Impact
- Cancer-related gene regulation
- Circular RNAs in diseases
- Immune cells in cancer
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Macrophage Migration Inhibitory Factor
Universidad Nacional Autónoma de México
2018-2025
Universidad de Zaragoza
2024
In recent years, immunomodulatory mechanisms of mesenchymal stem/stromal cells (MSCs) from bone marrow and other "classic" sources have been described. However, the phenotypic functional properties tumor MSCs are poorly understood. The aim this study was to analyze immunosuppressive capacity cervical cancer-derived (CeCa-MSCs) on effector T lymphocytes through purinergic pathway.We determined expression activity membrane-associated ectonucleotidases CD39 CD73 CeCa-MSCs normal tissue-derived...
The presence of TGF-β in the tumor microenvironment cervical cancer (CC) is important for progression. In this study, we analyzed effect on expression ectonucleotidases CD39 and CD73, which are involved generation adenosine (Ado), CC cells extracellular vesicles (EVs) secreted by these cells. Treatment HeLa CaSki 72 h with recombinant human increased CD73 20 30% 40 100%, respectively. addition SB505124, an inhibitor TGF-β1 receptor, or GW4869, exosome formation release, reduced release both...
The present study provides evidence showing that adenosine (Ado) increases the expression of programmed death ligand 1 (PD-L1) in cervical cancer (CeCa) cells by interacting with A2AR/A2BR and TGF-β1 acts an autocrine manner to induce PD-L1 expression, enhancing immunosuppressive effects CeCa on activated T lymphocytes (ATLs) CD8+ cytotoxic (CTLs) specific for antigenic peptides derived from E6 E7 proteins HPV-16. Interestingly, addition antagonists ZM241385 MRS1754, which are A2AR A2BR,...
Abstract Mesenchymal stromal cells (MSCs) together with malignant present in the tumor microenvironment (TME), participate suppression of antitumor immune response through production immunosuppressive factors, such as transforming growth factor beta 1 (TGF‐β1). In previous studies, we reported that adenosine (Ado), generated by adenosinergic activity cervical cancer (CeCa) cells, induces TGF‐β1 interacting A 2A R/A 2B R. study, provide evidence Ado MSCs derived from CeCa tumors (CeCa‐MSCs)...
Recently, a link between the biological activity of CD73 and tumorigenicity in solid tumors has been proposed. We previously reported that generation adenosine (Ado) by cervical cancer (CC) cells induces transforming growth factor-beta 1 (TGF-β1) production to maintain expression. In present study, we analyzed participation TGF-β1 expression development protumoral characteristics CaSki CC cultured as tumorspheres (CaSki-T) monolayers (CaSki-M). Compared with those CaSki-M cells, Ado ability...
The development of cervical cancer (CeCa) is associated with high-risk human papilloma virus (HR-HPV) infections, mainly HPV-16, which present in more than 50% cases. presence immunosuppressive factors the early stages disease also strongly linked to CeCa progression. In this context, it unknown whether ectonucleotidases CD39 and CD73, are involved production adenosine (Ado) that suppresses specific antitumor immune response, precursor lesions CeCa. pilot study, we analyzed CD73 their...
Recently, a link between the biological activity of CD73 in solid tumors and multidrug resistance protein (MRP) has been proposed. Cisplatin (CP) is most widely used anticancer agent to treat advanced recurrent cervical cancer (CC). However, protein-1 (MRP1) overexpressed approximately 85% these strongly associated with cisplatin (CPR). In this study, we examine involvement interaction adenosine (ADO) its receptors (ARs) MRP1 expression CC cells. We found that ADO positively modulates cells...
Persistent infection with high-risk human papillomavirus (HR-HPV) is the main factor in development of cervical cancer (CC). The presence immunosuppressive factors plays an important role this type cancer. To determine whether CD39 and CD73, which participate production adenosine (Ado), are involved progression CC, we compared concentrations hydrolytic activity these ectonucleotidases platelet-free plasma (PFP) samples between patients low-grade squamous intraepithelial lesions (LSILs) (...