In this paper, we present the design and fabrication of a novel chip-on-tip catheter, which uses microcamera optical fibres to capture in vivo images beating porcine heart thanks saline flush clear blood field. Here, demonstrate medical utility mechanical robustness catheter platform system, could be used for other diagnostic techniques, surgical guidance, clinical navigation. We also discuss some challenges system requirements associated with developing miniature prototype such study...

In vivo tissue imaging is an essential tool for medical diagnosis, surgical guidance, and treatment. However, specular reflections caused by glossy surfaces can significantly degrade image quality hinder the accuracy of systems. this work, we further miniaturisation reflection reduction techniques using micro cameras, which have potential to act as intra-operative supportive tools clinicians. order remove these reflections, two small form factor camera probes, handheld at 10 mm footprint...

Significance: Gas in scattering media absorption spectroscopy (GASMAS) enables noninvasive gas sensing the body. It is developing as a tool for diagnosis and monitoring of respiratory conditions neonates. Phantom models with relevant features to clinical translation GASMAS technology are necessary understand technical challenges potential applications this technique. State-of-the-art phantoms designed purpose have focused on optical properties anthropomorphic geometry thorax, contributing...

Capillary electrochromatography (CEC) is a separation technique that hybridizes liquid chromatography (LC) and capillary electrophoresis (CE). The selectivity offered by LC stationary phase results in rapid separations, high efficiency, selectivity, minimal analyte buffer consumption. Chip-based CE CEC techniques are also gaining interest, as the microchip can provide precise on-chip control over experiment. Capacitively coupled contactless conductivity detection (C4D) offers electrode...

Abstract Objective, reliable, accurate and cost‐effective methods for real‐time needle localization within the body are needed many different clinical applications. Electrical impedance (EI) is a technique used to identify biological tissues has potential provide during medical procedures. We have developed integrated with an sensor enable tip measurement tissue identification. This paper details device performance as it traversed test media, gelatine lard, at constant speeds provides...

This work reports on the development of an electrochemical sensor for on-line caffeine detection using screen printed graphite electrodes. The effects solution pH and pre-treatment procedures electrode performance have been discussed, as well modification surface increased sensitivity. Successful determination in soft drink samples is described. results indicate potential sensors to compare compete with current off-line methods analysis, such HPLC, allowing both a reduction time cost product...

Abstract Cell‐based biosensors treat living cells as sensing elements and are able to detect the functional information of biologically active analytes. Monitoring cytotoxicity with high sensitivity, rapidity at low cost is great interest in fields clinical diagnostics, environmental monitoring, food safety security. This research investigates behaviour different cell types on nanostructured architectures. The development cell‐based assays using bioimpedance devices has potential screening...

Chronic-pain (CP) affects at least 10% of the world's population, and costs our society $1T. There is currently no effective approach to treating CP. To this end, there an urgent need in pain-research community enable monitoring pain-related biomarkers, e.g. circulating DNAs, cytokines, endocannabinoids, over a long-period time (> 3 months). Here, we show how implant incorporated with photonic nanomaterials known as upconversion nanoparticles (UCNP) are particularly suited for such purposes....

Fetal hypoxic brain injury is the deprivation of oxygen during labour and associated with up to 60% mortality. The gold standard fetal monitoring labour, cardio tocograph (CTG) blood sampling are poor at diagnosing hypoxia continuously non-invasively. Our research towards developing a non-invasive, continuous assessment system using long wavelength near-infrared spectroscopy through fiber optic based reflectance. Lactate key biomarker for determination in babies birth. For successful...

Cardiovascular imaging with camera-on-tip endoscopes has the potential to provide physiologically relevant data on tissue state and device placement that can improve clinical outcomes. In this work, we review unmet need for image-based in vivo cardiovascular diagnostics guidance minimally invasive procedures. We present a 7 Fr endoscope fibre-coupled multispectral illumination includes methods blood-filled field of view (FOV). demonstrate be navigated from femoral artery cardiac regions such...

Abstract Our research is concentrated on development of a ‘smart’ needle which will improve the safety ultrasound-guided peripheral nerve block (USgPNB) by providing clinician with bioimpedance data to identify type tissue tip in contact with. This paper outlines feasibility study performed determine electrical number different types and extent they can be differentiated from each other based this variable factor. All cells have properties results characteristic profiles. A macro-needle was...

We propose a handheld single photon avalanche diode (SPAD) micro-camera probe for wide-field in-vivo fluorescence lifetime imaging (FLIm) applications. The presented includes novel 3D stacked 1.4 mm × SPAD array, an integrated excitation light source, and optics. spatial temporal performance of the system was characterised using USAF test target range beads.

A novel Microchip Capillary Electrophoresis (MCE) device, for use with Capacitively Coupled Contactless Conductivity Detection (C4D) technique incorporating a 200 nm gold deposited pick-up electrodes on Pyrex glass wafer is described. The PDMS (Polydimethylsiloxane) microchip was fabricated by the transfer print from an etched silicon through conventional lithography method. sealed 100 urn-thick bio-glass, coupled cell. fully 3d-printed cartridge encloses all essential parts, including chip...

This novel capillary electrophoresis microchip, or also known as μTAS (micro total analysis system) was designed to separate complex aqueous based compounds, similar commercial CE & microchip (capillary electrophoresis) systems, but more compact. system can be potentially used for mobile/portable chemical equipment. Un-doped silicon wafer ultra-thin borofloat glass (Pyrex) wafers have been fabricate the device. Double-L injection feature, micro pillars column, bypass separation channel...

Bioimpedance is the opposition to flow of an applied electrical current through biological tissues1. Our research group designed and fabricated bipolar micro-sensors on tip a silicone probe, capable measuring tissue impedance. It known that bioimpedance cultured cancer cells differs substantially from healthy cell lines. We hypothesised in surgically excised human would be significantly different surrounding tissue. To test this hypothesis, we study evaluate diseased breast specimens. This...

The paper is presenting the development of a sensor system dedicated to monitor environment eukaryotic cells culture acting as biosensors for toxins detection. we are containing pH, and temperature sensors integrated into microfluidic channels. have role characterize living conditions (temperature pH) monitoring cell biochip 24 h day providing data acquisition Labview based. continuous 46 pH has been performed will be presented. These stored interpretation decision. characteristics on-line...

Abstract A gold dual‐microelectrode probe patterned on a silicon substrate for bio‐impedance measurement was fabricated, characterised and tested different types of tissues. The aim this study is to fabricate device capable using bioimpedance discriminate tissue types. This proof concept the meat gel/lard phantom which mimics fat muscle. initial results demonstrated that had excellent electrochemical recording potential. data derived differentiation between biological Bio‐impedance may...

Abstract Gold nanopillars have been successfully fabricated on top of interdigitated gold electrodes deposited a Pyrex substrate and these were used for cytotoxicity monitoring immortalized cells through the electrochemical impedance spectroscopy technique. These via contact metal deposition. E-beam lithography was to define pattern with dimensions 150nm diameter 500nm distance between their edges in honeycomb-like structure. together a, relatively, low aspect ratio ( ~50niτi tall) chosen...

Intra-partum hypoxia is the principal cause of death for every 2 in 10000 infants. Monitoring during child-birth will not only prevent infant mortality, but also help cerebral palsy 10-20% surviving babies. Current monitoring techniques either use an indirect biomarker (heart-rate cardiotocograph) or measure downstream biomarkers intermittently and invasively (fetal blood sampling). For complete fetal wellbeing monitoring, a continuous non-invasive assessment multiple needed birth. To...

Surgical guidance and diagnostics by diffuse optical imaging using micro camera technology at the tip endoscopic probes have potential to act as intra-operative supportive tools for clinicians. Micro need address undesirable specular reflections in order be clinically relevant. In this work we overcome caused glossy uneven tissue surface. We adapt compare two techniques miniaturised designed view tissue. Two are developed different modalities remove these surface reflections, with...

Surgical guidance and diagnostics by diffuse optical imaging using micro camera technology at the tip endoscopic probes have potential to act as intra-operative supportive tools for clinicians. Micro need address undesirable specular reflections in order be clinically relevant. In this work we overcome caused glossy uneven tissue surface. We adapt compare two techniques miniaturised designed view tissue. Two are developed different modalities remove these surface reflections, with...