A5001161332- Coronary Interventions and Diagnostics
- Elasticity and Material Modeling
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Imaging and Diagnostics
- Acute Ischemic Stroke Management
- Cardiovascular Health and Disease Prevention
- Protease and Inhibitor Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Blood properties and coagulation
- Ultrasound Imaging and Elastography
- Acute Myocardial Infarction Research
- Peripheral Artery Disease Management
- Cellular Mechanics and Interactions
- Congenital Heart Disease Studies
- Lipoproteins and Cardiovascular Health
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Valve Diseases and Treatments
- Connective tissue disorders research
- Thermography and Photoacoustic Techniques
- Wireless Power Transfer Systems
- Advanced Surface Polishing Techniques
- Infrared Thermography in Medicine
- Probabilistic and Robust Engineering Design
- Ultrasound and Hyperthermia Applications
- Mathematical Biology Tumor Growth
Erasmus MC
2015-2025
Delft University of Technology
2020-2025
Erasmus University Rotterdam
2011-2023
Rensselaer Polytechnic Institute
2015-2016
Mechanical properties of thromboemboli play an important role in the efficacy endovascular thrombectomy (EVT) for acute ischemic stroke. However, very limited data on mechanical human stroke thrombi are available. We aimed to mechanically characterize retrieved with EVT, and assess relationship between thrombus composition stiffness.Forty-one from 19 patients who underwent EVT July October 2019 were analyzed, directly after EVT. performed unconfined compression experiments determined tangent...
Rupture of the cap a vulnerable plaque present in coronary vessel may cause myocardial infarction and death. Cap rupture occurs when peak stress exceeds strength. The mechanical within depends on morphology material characteristics components. A parametric study was conducted to assess effect intima stiffness stress. Models with idealized geometries based histology images human arteries were generated by varying geometric features. constructed multi-layer models contained adventitia, media,...
The fibrous cap of an atherosclerotic plaque may be prone to rupture if the occurring stresses exceed strength cap. Rupture can cause acute thrombosis and subsequent ischaemic stroke or myocardial infarction. A reliable prediction probability is essential for appropriate treatment atherosclerosis. Biomechanical models, which compute strain, are promising provide a more risk prediction. However, these models require knowledge local biomechanical properties tissue. For this purpose, we...
Atherosclerotic plaque rupture is the primary trigger of fatal cardiovascular events. Fibrillar collagen in atherosclerotic plaques and their directionality are anticipated to play a crucial role rupture. This study aimed assessing 3D fiber orientations architecture for first time. Seven carotid were imaged ex-vivo with state-of-the-art Diffusion Tensor Imaging (DTI) technique, using high magnetic field (9.4 Tesla) MRI scanner. A spin-echo sequence uni-polar diffusion sensitizing pulsed...
Endovascular thrombectomy procedures are significantly influenced by the mechanical response of thrombi to multi-axial loading imposed during retrieval. Compression tests commonly used determine compressive ex vivo thrombus and clot analogue stiffness. However, there is a shortage data in tension. This study compares tensile analogues made from blood healthy human donors range compositions. Citrated whole was collected six donors. Contracted non-contracted fibrin clots, clots reconstructed...
Atherosclerotic plaque rupture in carotid arteries is a major cause of cerebrovascular events. Plaque the mechanical failure heterogeneous fibrous tissue. Local characterization tissue's properties and collagen architecture are great importance to have insights for clinical event prevention. Previous studies were limited average global structural characterization, did not provide necessary local information. In this study, we assessed tissue, by analyzing 30 tissue strips from 18 plaques....
Many cardiovascular events are triggered by fibrous cap rupture of an atherosclerotic plaque in arteries. However, rupture, including the impact cap's structural components, is poorly understood. To obtain better mechanistic insights a biologically and mechanically controlled environment, we previously developed tissue-engineered model. In current study, characterized (local) mechanical properties these analogs. Twenty-four collagenous analogs were cultured. The imaged with multiphoton...
Accumulating evidence highlights the existence of distinct morphological subtypes intracranial carotid arteriosclerosis. So far, little is known on prevalence these and subsequent stroke risk in general population. We determined arteriosclerosis assessed associated with subtypes.Between 2003 2006, 2391 stroke-free participants (mean age 69.6, 51.7% women) from population-based Rotterdam Study underwent noncontrast computed tomography to visualize calcification arteries as a proxy for...
Heart attacks are often caused by rupture of caps atherosclerotic plaques in coronary arteries. Cap occurs when cap stress exceeds strength. We investigated the effects plaque morphology and material properties on stress. Histological data from 77 lesions were obtained segmented. In these patient-specific cross sections, peak stresses computed using finite element analyses. The analyses 2D, assumed isotropic behavior, ignored residual stresses. To represent wide spread properties, we applied...
Atherosclerotic plaque rupture in carotid arteries is a major source of cerebrovascular events. Calcifications are highly prevalent plaques, but their role remains poorly understood. This work studied the morphometric features calcifications plaques and effect on stress distribution fibrous tissue at calcification interface, as potential clinical events.A comprehensive analysis 65 histology cross-sections from 16 was performed to identify morphology (size shape) location calcifications,...
Biomechanical models are used extensively to study risk factors, such as peak stresses, for vulnerable atherosclerotic plaque rupture. Typically, 3D patient-specific arterial reconstructed by interpolating between cross sectional contour data which have a certain axial sampling, or image, resolution. The influence of the sampling resolution on computed well comparison with 2D simulations, is quantified in this study. A set histological four human coronary arteries was were high (HS) and low...
Optical coherence elastography (OCE), a functional extension of optical tomography (OCT), visualizes tissue strain to deduce the tissue’s biomechanical properties. In this study, we demonstrate intravascular OCE using 1.1 mm motorized catheter and 1.6 MHz Fourier domain mode-locked OCT system. We induced an intraluminal pressure change by varying infusion rate from proximal end catheter. analysed pixel-matched phase between two different frames yield radial strain. Imaging experiments were...
Biomechanical models have the potential to predict plaque rupture. For reliable models, correct material properties of components are a prerequisite. This study presents new technique, where high resolution ultrasound displacement imaging and inverse finite element (FE) modeling is combined, estimate components. Iliac arteries with plaques were excised from 6 atherosclerotic pigs subjected an inflation test pressures ranging 10 120 mmHg. The imaged frequency 40 MHz ultrasound. Deformation...
Atherosclerotic plaque rupture is recognized as the primary cause of cardiac and cerebral ischaemic events. High structural stresses have been shown to strongly correlate with rupture. Plaque can be computed finite-element (FE) models. Current FE models employ homogeneous material properties for heterogeneous atherosclerotic intima. This study aimed evaluate influence intima heterogeneity on stress computations. Two-dimensional were constructed from histological images human coronaries (n =...
This paper explores energy dissipation in ex vivo liver tissue during radiofrequency current excitation with application electrosurgery. Tissue surface temperature for monopolar electrode configuration is measured using infrared thermometry. The experimental results are fitted to a finite-element model transient heat transfer taking into account storage and conduction order extract information about "apparent" specific heat, which encompasses phase change. average apparent determined low...
Plaque rupture in atherosclerotic carotid arteries is a main cause of ischemic stroke and it correlated with high plaque stresses. Hence, analyzing stress patterns essential for specific risk assessment. However, the critical information multicomponent material properties still lacking greatly. This work aims to characterize component-wise human under (almost) physiological loading conditions. An inverse finite element modeling (iFEM) framework was developed fibrous intima vessel wall 13...
In this paper, we report the development of a technique to characterize layer-specific nonlinear material properties soft tissue in situ with potential for vivo testing. A elastography robotic arm system comprising robotically manipulated 30 MHz high-resolution ultrasound probe, custom designed compression head, and load cells has been developed perform imaging on target measure reaction forces. multilayer finite element model is iteratively optimized identify coefficients each layer....