A predictive model to estimate post-donation glomerular filtration rate (eGFR) and risk of CKD at 1-year was developed from a Toulouse-Rangueil cohort in 2017 showed an excellent correlation the observed eGFR. We retrospectively analyzed all living donor kidney transplants performed single center 1998 2020. Observed eGFR using CKD-EPI formula compared predicted (CKD-EPI, mL/min/1.73 m2) = 31.71+ (0.521 × preoperative eGFR) - (0.314 age). 333 donors were evaluated. good (Pearson r 0.67; p <...

Background The use of kidney donors with hepatitis C virus (HCV) has been arising as a possibility to increase the donor pool. It encompasses both positive and negative viremia, particularly since advent direct antiviral agents that produce sustained virologic response. Methodology We conducted retrospective observational study describe experience our transplantation center in HCV antibody-positive (HCV-Ab+) kidneys. Results performed five transplants HCV-Ab+ donors. median age recipients...

Kidney-pancreas transplantation is the preferable therapeutic option for patients with type 1 diabetes mellitus and end-stage kidney disease. We describe case of a 35-year-old pancreas-kidney transplant recipient dual-graft failure that presents massive hematochezia hemodynamic instability, evolving into hemorrhagic shock. The diagnostic assessment revealed fistula between pseudoaneurysm right common iliac artery adjacent transplanted duodenum segment, rare but life-threatening cause...

Acute interstitial nephritis (AIN) is an important cause of acute kidney injury (AKI) that has been historically associated with the presence urine eosinophils (UE). In more recent studies, this association between AIN and UE grown weaker and, to our knowledge, only one study used biopsy as diagnosis standard. years, new AKI biomarkers, such interleukin-9 tumour necrosis factor-α, have gained interest, yet these are not widely available. To investigate performance screening test in cases...

Monoclonal gammopathy of renal significance (MGRS) is a group pathologies that includes all kidney disorders related to monoclonal protein in patients without diagnostic criteria for B-cell malignancies. There are multiple MGRS-associated disorders, and more still being discovered, which makes this diagnosis challenging. The relationship between gammopathies thrombotic microangiopathy (TMA) growing interest literature. This article describes the case patient with newly diagnosed MGRS,...

Extramammary Paget's disease is a rare cutaneous malignancy affecting areas with high concentration of apocrine glands. The authors present 77-year-old male followed in the General Surgery consultation due to anal pruritus complaints an evolution around 20 years and recent lower gastrointestinal bleeding. A colonoscopy was requested patient observed by Gastroenterology team this context. objective examination showed erythematous-whitish plaque well-defined, slightly exudative verrucous...

Pneumocystis jirovecii (PJ) is an environmental and opportunistic fungus with affinity to the lung tissue and, in particular, type I pneumocytes.Immunocompromised are most affected, pneumonia (PJP) still a significant cause of infection these patients. 1Among solid organ transplant (SOT) recipients, PJP was associated high mortality rates. 2 After universal institution trimethoprim-sulfamethoxazole (TMP-SMX) for prophylaxis SOT recipients during first-year post-transplantation occurrence...

Abstract Background and Aims There is a high-risk of progressive chronic kidney disease (CKD) in patients with neurogenic bladder (NB) early detection estimated glomerular filtration rate (eGFR) reduction essential, preventing delayed diagnosis. Creatinine-based formulas can overestimate eGFR these due to decreased muscle mass. This study aims compare calculated by different equations using serum creatinine (Cr) and/or cystatin C (CysC), children NB, analyse the influence demographic...

Abstract Background and Aims Lupus nephritis is a well know manifestation of systemic lupus erythematosus (SLE) it can progress to end stage kidney disease (ESKD) in 10-30% patients [1]. Several studies have been conducted find out whether proteinuria detected earlier the course associated with worse related outcomes, such as progression chronic [2]. Method We retrospectively reviewed cohort 67 referenced our center diagnosis until 2019. evaluated (g/g) random urine sample measured 12 months...

Abstract Background and Aims In the pediatric population, transplantation remains first-line therapy in patients with end-stage renal disease (ESRD). However, it is not always possible, increasing need for other kidney replacement (KRT) modalities, hemodialysis (HD) has been growing as a modality choice recent years. To provide quality HD treatment, efficient vascular access mandatory, arteriovenous fistula (AVF) advocated best long-term option. its creation technically challenging,...

Abstract Background and Aims Minimal change disease (MCD) is the main cause of nephrotic syndrome in pediatric age it responsible for 10-25% cases adults. It characterized by minimal glomerular abnormalities light microscopy, usually without immunoglobulins or complement deposits immunofluorescence (IF). There a subgroup patients that presents with IgM deposition IF, which has been described as more aggressive disease, frequent relapses [1], dependence steroids [2] worse outcomes. Method...

Abstract Background and Aims Hepatocyte nuclear factor 1β (HNF1β)-associated disorder is a rare entity that may present with wide range of clinical phenotypes. Genetic transmission autosomal dominant, penetrance incomplete, expression variable, which can contribute to different presentations, raising difficulties reach the diagnosis. The most common findings are renal cysts, responsible for kidney function decline, as well diabetes mellitus, among other possible organs’ manifestations such...

Abstract BACKGROUND AND AIMS Living donor kidney transplantation (LDKT) provides the best outcomes of all renal replacement modalities, including survival and quality life. Studies on association between pre-donation estimated glomerular filtration rate (eGFR) graft have yielded inconsistent results. Two eGFR thresholds are generally used to accept or deny a (respectively, ≥90 &amp;lt;60 mL/min/1.73 m2), with 60–89 m2 as an intermediate range in which decision is based other factors. In this...

Abstract BACKGROUND AND AIMS Kidney transplantation (KT) improves survival and quality of life patients with end-stage renal disease. However, there is still an unbalance between supply demand for kidneys. To increase the number available grafts reduce waiting list transplantation, recruitment older living donors has expanded. This approach remains controversial several reasons, including impact kidney function decline on long-term graft recipient survival. We aimed to evaluate donor (LD)...

Abstract BACKGROUND AND AIMS Living donor kidney transplantation (LDKT) is the best treatment for end-stage disease and associated with better recipient outcomes than deceased transplantation. donors (LKD), however, seem to be at increased risk of chronic (CKD), which mandates a careful selection reduce chances selecting developing CKD. A predictive model estimate 1-year post-donation estimated glomerular filtration rate (eGFR) CKD was developed from Toulouse-Rangueil cohort in 2017 [1] has...

In most cases, the atypical hemolytic uremic syndrome (aHUS) is a genetic disease resulting from defects in regulation of complement cascade, which conditions development thrombotic microangiopathy. Clinically, aHUS presents with acute kidney injury, thrombocytopenia, and microangiopathic anemia, frequent renal extrarenal phenomena. Early diagnosis treatment are essential. Plasmapheresis an alternative being frequently used considering high cost eculizumab, despite its lower clinical...

Older to older living kidney transplantation is an acceptable alternative avoid dialysis, improve quality of life and maintain favorable long-term outcomes patients with end-stage disease. However, the management these complex acceptance donors recipients remains controversial. The usually have several comorbidities that may complicate postoperative course increase risk We present a clinical case between donor recipient, both over 70 years old, who evolved stage 3 chronic disease, without...

Introduction: As the obesity epidemic worsen, kidney transplant (KT) candidates are also more obese as well their potential living and deceased donors (DD). Increased scarcity of organs makes it necessary to adjust acceptance criteria has led (LD) that were previously declined. Many studies found donor recipient significantly related a decreased graft patient survival on both DD transplant. We aimed investigate impact body mass index (BMI) in cohort recipients (LKT). Methods: This is...

Background: Living donor kidney transplantation (LDKT) is the best treatment for end-stage disease (ESKD). Long term follow-up data of donors are reassuring but some will develop chronic (CKD) and, rarely, ESKD. Precise tools to define these risks lacking.A predictive model estimate 1-year post-donation glomerular filtration rate (eGFR) and risk CKD was developed from a Toulouse-Rangueil cohort in 2017[1] has been shown have good correlation observed eGFR[2, 3].We aimed externally validate...

Pneumocystis jirovecii (PJ) opportunistic infections occur in immunocompromised patients impacting significantly hospitalizations and mortality. Trimethoprim-sulfamethoxazole (TMP-SMX) is universally used as prophylaxis of pneumonia (PJP) therefore, this infection rare condition solid organ transplant (SOT) recipients. We present a case 46-years-old male, who received an ABO-incompatible with prior desensitization protocol plasmapheresis, rituximab, anti-CMV immunoglobulin. IgG anti-B title...