Abstract Background and Aims Minimal changes disease (MCD) is responsible for 10-25% of nephrotic syndrome cases in adults. It can have a primary or secondary aetiology, being associated with diseases like infections, atopy even haematological malignancies. There described association between MCD myasthenia gravis (MG) the literature, which we will explore this case report. Clinical Case An autonomous 67 years old female, healthy except overweight develops diplopia dysphagia, diagnosed...

Introduction: The classification of the severity obstructive sleep apnea (OSA) based on Apnea/Hypopnea Index (AHI) does not reflect heterogeneity and prognosis disease. Baveno proposes a new assessment system that includes symptoms comor-bidities. aim our study was to evaluate application in clinical practice explore its association with indices, adherence therapy over 6-months period. Material methods: Prospective including patients diagnosed OSA between January July 2021 conducted....

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease of unknown cause that occurs sporadically, but it can also occur in families and so named as Familial Pulmonary Fibrosis (FPF). Some forms FPF overlaps IPF features, namely the radiological histological pattern usual pneumonia (UIP). Genetic environmental factors commonly play an important role pathogenesis most identified mutations involve telomerase complex. Here, we report rare case male at age 44, whom genetic...

The NELSON study demonstrated a positive association between computed tomography scanning and reduced mortality associated with lung cancer. COPD-LUCSS-DLCO is tool designed to improve screening selection criteria of cancer for chronic obstructive pulmonary disease patients. aim this was examine compare the discriminating value both scores in community-based cohort patients.A retrospective patients followed pulmonology consultation period 10 years (2009-2019) conducted. score were calculated...

Hemophilia A is a congenital deficiency of blood coagulation factor VIII (fVIII) that causes prolonged bleeding time. Dialysis in these patients can be challenging and several aspects must considered, namely the patient's will characteristics, dialysis modality, access, hypocoagulation need for fVIII infusion.

Genome-wide association studies (GWASs) have revealed numerous loci associated with breast cancer risk, yet the precise causal variants, their impact on molecular mechanisms, and affected genes often remain elusive. We hypothesised that specific variants exert influence by affecting cis-regulatory alternative splice elements. An analysis of splicing quantitative trait (sQTL) in healthy tissue from female individuals identified multiple linked to alterations ratios. Through colocalisation...

O presente trabalho trata-se de uma revisão literatura. A malária é provocada por protozoários do gênero Plasmodium, que são disseminados mosquitos da espécie Anopheles, especialmente o Anopheles darlingi no Brasil. ciclo vida parasita consiste em invadir os glóbulos vermelhos após a transmissão pelo mosquito, levando à infecção. enfermidade representa um sério desafio saúde pública, particularmente na Amazônia, abriga maior parte dos casos Brasil devido às condições ambientais propícias....

<b>Introduction:</b> Influenza A (IA), B (IB) and Respiratory Syncytial Virus (RSV) have been recognized as a major cause of acute respiratory tract infection. <b>Objectives:</b> To analyse clinical demographic characteristics outcomes IA, IB RSV infections in adults hospitalized patients pulmonology ward during the 17/18 flu-season. <b>Methods:</b> Retrospective analysis records with or confirmed <b>Results:</b> total 121 nasopharyngeal swabs were performed, which 57% positive (69/121). IA...

<b>Introduction:</b> Pulmonary hypertension (PH) is a severe complication of COPD and often presents with non-specific symptoms. Red cell distribution width (RDW) measure red blood size heterogeneity that can be elevated in situations increased destruction. <b>Objectives:</b> The aim this study was to investigate whether RDW might predictor PH patients. <b>Methods:</b> This cohort retrospectively enrolled 93 patients COPD, including 30 cases 63 without PH. values were obtained within days...

Asthma is a chronic disease with clinical variations throughout its course. Periods of symptom aggravation can occur the need to escalate therapy. Nevertheless, further investigation should be considered when atypical manifestations appear or worsening symptoms occurs. Proximal tracheal/bronchial obstruction mimic observed in patients asthma. Primary benign tracheal tumors are rare, but constitute cause for such symptoms. We present case report patient asthma and lesion.

Introduction. Several biological agents for the treatment of severe asthma have been approved self-administration on an outpatient basis in last years. However, data impact home administration outcomes such as control and quality life real-life settings are sparse. Being this knowledge crucial clinical practice, study aimed to assess patients who transitioned from day hospital therapy administration. Methods. A single-center prospective analysis 33 treated with biologics asthma, switched was...

Computed tomographic (CT) phenotypic patterns of chronic obstructive pulmonary disease (COPD) identify different clinical features disease. The impact these variables on the physiological response to exercise has been focus a great deal research as it allows more individualized approaches. aim our study was evaluate relationships between CT phenotyping subjects with COPD and ventilatory during cardiopulmonary testing (CPET). Subjects were classified into four phenotypes based metrics...

Introduction: Malignant pleural effusion (MPE) is a common manifestation in patients with advanced lung cancer. The LENT score was developed as risk stratification system to predict the survival of these patients. However, following discovery molecular markers and new era personalized therapy, prognostic estimation became challenging exercise. aim this study evaluate performance predicting MPE EGFR ALK mutated adenocarcinoma. Methods: A retrospective single-center from adenocarcinoma...

Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)

Abstract Background and Aims Minimal change disease (MCD) is the main cause of nephrotic syndrome in pediatric age it responsible for 10-25% cases adults. It characterized by minimal glomerular abnormalities light microscopy, usually without immunoglobulins or complement deposits immunofluorescence (IF). There a subgroup patients that presents with IgM deposition IF, which has been described as more aggressive disease, frequent relapses [1], dependence steroids [2] worse outcomes. Method...

Adult Onset Still's Disease (AOSD) is a rare, systemic inflammatory disease.Its main manifestations consist of fever, arthralgias and evanescent rash the diagnosis essentially clinical.The authors present case 43-year-old woman admitted to Emergency Department because odynophagia arthralgia for about 2 weeks.Complementary diagnostic tests showed elevation C-Reactive Protein (CRP) leukocytosis.After exhaustive investigation, AOSD was made.The intend alert importance inclusion this pathology...