A5082715573- Bone health and treatments
- Cytokine Signaling Pathways and Interactions
- Radiopharmaceutical Chemistry and Applications
- Immune cells in cancer
- Bone Metabolism and Diseases
- HER2/EGFR in Cancer Research
- Fibroblast Growth Factor Research
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Adenosine and Purinergic Signaling
- Epigenetics and DNA Methylation
- Chronic Myeloid Leukemia Treatments
- Bone Tissue Engineering Materials
- Estrogen and related hormone effects
- Bone health and osteoporosis research
- MicroRNA in disease regulation
- Multiple Sclerosis Research Studies
- RNA Research and Splicing
- Orthopaedic implants and arthroplasty
- Monoclonal and Polyclonal Antibodies Research
- Reproductive System and Pregnancy
- demographic modeling and climate adaptation
- Immune Response and Inflammation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
University of Turku
2016-2025
University of Eastern Finland
2014-2017
Kazan Federal University
2017
Kazan Institute of Biochemistry and Biophysics
2017
Finland University
2014
Turku University Hospital
2013
Åbo Akademi University
2000-2009
Turku Centre for Biotechnology
2000-2009
Finnish Institute of Occupational Health
2005
The immune system plays a major role in cancer progression. In solid tumors, 5-40 % of the tumor mass consists tumor-associated macrophages (TAMs) and there is usually correlation between number TAMs poor prognosis, depending on type. resemble M2 macrophages. Unlike M1-macrophages which have pro-inflammatory anti-cancer functions, M2-macrophages are immunosuppressive, contribute to matrix-remodeling, hence favor growth. not fully understood breast Macrophage infiltration (CD68) activation...
This overview addresses the recent research developments in role of tumour-associated macrophages (TAM) bone metastasis biology and management breast prostate cancer as well primary lung metastatic osteosarcoma. Immunosuppressive M2-type TAMs have been shown to associate with poor prognosis. Throughout their life cycle, (Macs) can adapt environmental cues influence surroundings by secreting different cytokines enzymes crucial matrix remodelling, infection fighting, immune regulation and/or...
The ErbB1 and ErbB2 receptors are oncogenes with therapeutic significance in human cancer, whereas the transforming potential of related ErbB4 receptor has remained controversial. Here, we have addressed whether four alternatively spliced isoforms differ regulating cellular responses relevant for tumor growth. We show that two necrosis factor-α converting enzyme (TACE)-cleavable (the juxtamembrane [JM]-a isoforms) were overexpressed a subset primary breast cancers together TACE....
The role of the estrogen receptor α (ERα) in bone-forming cells is incompletely understood at present. To examine vivo effects ERα these cells, we generated a mouse strain which gene inactivated osteoblasts via osteocalcin promoter-regulated cyclic recombinase (Cre) activity (ERαΔOB/ΔOB). This enabled micro-computed tomography- and histomorphometry-based analysis ERα-mediated mice, systemic are intact. In female ERαΔOB/ΔOB trabecular cortical bone volumes were significantly reduced (31.5...
Recruitment of vascular smooth muscle cells (SMC) by endothelial (EC) is essential for angiogenesis. Endothelial-derived heparin binding EGF-like growth factor (HB-EGF) was shown to mediate this process signaling via ErbB1 and ErbB2 receptors in SMCs. 1) Analysis ErbB-ligands demonstrated that primary ECs expressed only HB-EGF neuregulin-1. 2) Primary SMCs ErbB2, but not ErbB3 or ErbB4. 3) Consistent with their known receptor specificities, recombinant HB-EGF, neuregulin-1, stimulated...
ABSTRACT Semliki Forest virus (SFV) is a mosquito-transmitted pathogen of small rodents, and infection adult mice with SFV4, neurovirulent strain SFV, leads to lethal encephalitis in few days, whereas infected the avirulent A7(74) remain asymptomatic. In neurons, unable form virions hence does not reach critical threshold neuronal damage. To elucidate molecular mechanisms neurovirulence, we have cloned sequenced entire 11,758-nucleotide genome compared it highly SFV4 virus. We found several...
Human Vγ9Vδ2 T cells recognize in a butyrophilin 3A/CD277-dependent way microbial (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) or endogenous pyrophosphates (isopentenyl [IPP]). Nitrogen-bisphosphonates such as zoledronic acid (ZOL) trigger selective γδ cell activation because they stimulate IPP production monocytes by inhibiting the mevalonate pathway downstream of synthesis. We performed comparative analysis capacity purified monocytes, neutrophils, and CD4 to serve accessory for...
Macrophage metabolism is closely linked to their phenotype and function, which why there growing interest in studying the metabolic reprogramming of macrophages. Bioactive glass (BG) S53P4 a bioactive material used especially bone applications. Additionally, BG has been shown affect macrophages, but mechanisms through possible immunomodulatory effects are conveyed remain unclear. According results presented here, lipopolysaccharide (LPS) induced suppression oxidative phosphorylation rescued...
Giant panda's evolutionary adaptation for using bamboo as food has been demonstrated by the morphology premolars, and anatomy function of temporomandibular joint. Pandas feed on leaves, limbs stem containing phytoliths. We characterized phytoliths two species in order to determine which parts could contain wear-causing explain panda feeding behavior remove cortex before eating. Two (Phyllostachys aureosulcata Phyllostachys bissetii) were their inorganic content, morphological chemical...
Bone homeostasis is maintained by the coupled actions of hematopoietic bone-resorbing osteoclasts (OCs) and mesenchymal bone-forming osteoblasts (OBs). Here we identify early B cell factor 1 (Ebf1) transcriptional coregulator Zfp521 as components machinery that regulates bone through coordinated effects in both lineages. Deletion OBs led to impaired formation increased OB-dependent osteoclastogenesis (OC-genesis), deletion cells revealed a strong cell-autonomous role for OC progenitors. In...
Accelerated fetal myocardial growth with altered cardiac function is a well-documented complication of human diabetic pregnancy, but its pathophysiology still largely unknown. Our aim was to explore the mechanisms remodeling and cardiovascular hemodynamics in rat model maternal pregestational streptozotocin-induced hyperglycemia. The hyperglycemic group comprised 107 fetuses (10 dams) control 219 (20 dams). Fetal assessed serially by Doppler ultrasonography. thoracic area ratio, newborn...
Tumour stromal macrophages differentiate to tumour-associated (TAMs) with characteristics of immunosuppressive M2-type macrophages, having a central role in promoting tumour vascularisation, cancer cell dissemination and suppressing anti-cancer immune responses. Bisphosphonates (BPs) are group drugs commonly used as anti-resorptive agents. Further, nitrogen containing BPs like Zoledronate (ZOL), known cause unspecific inflammatory reactions hence the hypothesis that its use could modulate...
Material-induced ossification is suggested as a suitable approach to heal large bone defects. Fiber-reinforced composite–bioactive glasses (FRC-BGs) display properties that could enhance the of calvarial Here, we analyzed healing processes FRC-BG implant in vivo from perspective material-induced ossification. Histological analysis implant, which was removed 5 months after insertion, showed formation viable, noninflammatory mesenchymal tissue with newly-formed mineralized woven bone, well...
Different biomaterials have been clinically used as bone filling materials, although the mechanisms behind biological effects are incompletely understood. To address this, we compared of five different biomaterials: two bioactive glasses (45S5 and S53P4), hydroxyapatite (HAP), carbonated apatite (CAP), alumina on in vitro migration viability pre-osteoblastic cells. In addition, studied biomaterials' calcium release cell migration, differentiation. We found differences between materials...
Neuropeptide Y (NPY) co-localized with noradrenaline in central and sympathetic nervous systems seems to play a role the control of energy metabolism. In this study, aim was elucidate effects pathophysiological mechanisms increased NPY catecholaminergic neurones on accumulation body adiposity.Transgenic mice overexpressing under dopamine-beta-hydroxylase promoter (OE-NPY(DβH) ) wild-type were followed for weight gain fat content. Food intake, expenditure, physical activity, temperature,...
We previously identified 2 Finnish families with dominantly inherited, low-turnover osteoporosis caused by mutations in WNT1 or PLS3.This prospective, longitudinal, uncontrolled study was undertaken to evaluate whether these patients respond teriparatide.We recruited 6 adults (median age, 54 years); 3 a missense mutation, c.652T>G, and PLS3 splice c.73-24T>A, receive teriparatide 20 μg daily for 24 months. Five had used bisphosphonates.Outcome measures included lumbar spine hip bone mineral...
The active role of chemokines in the central nervous system (CNS) during pathogenesis experimental autoimmune encephalomyelitis (EAE) has been clearly established. In this study expression pattern several and cytokines was elucidated using reverse transcription-PCR immunohistochemistry a recently established EAE model BALB / c mouse that is characterized by CNS infiltration polymorphonuclear neutrophils. Elevated mRNA levels MIP-1α, MIP-2 MCP-1 were detected diseased mice, whereas no...
Abstract The association of hormonal contraception with increased risk inflammatory bowel disease (IBD) observed in females suggests involvement ovarian hormones, such as estradiol, and the estrogen receptors progression intestinal inflammation. Here, we investigated effects prophylactic SERM2 estradiol supplementation dextran sulfate sodium‐induced colitis using mice intact ovaries ovariectomized (OVX) female mice. We found that graded score was threefold reduced OVX mice, compared to...