A5033867833- RNA Interference and Gene Delivery
- Psoriasis: Treatment and Pathogenesis
- Organoboron and organosilicon chemistry
- Renin-Angiotensin System Studies
- Boron Compounds in Chemistry
- Obstructive Sleep Apnea Research
- Virus-based gene therapy research
- Fungal and yeast genetics research
- Autoimmune and Inflammatory Disorders Research
- Cancer Research and Treatments
- Advanced Fluorescence Microscopy Techniques
- Rheumatoid Arthritis Research and Therapies
- Cell Image Analysis Techniques
- TGF-β signaling in diseases
- Neuroscience of respiration and sleep
- Angiogenesis and VEGF in Cancer
- Immunodeficiency and Autoimmune Disorders
- Human Health and Disease
- Temporomandibular Joint Disorders
- Inflammasome and immune disorders
- Protein Degradation and Inhibitors
- Thermoregulation and physiological responses
- Eosinophilic Esophagitis
- Dysphagia Assessment and Management
- bioluminescence and chemiluminescence research
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy
2008-2025
Polish Academy of Sciences
2008-2025
Wroclaw Medical University
2023
Abstract Sleep bruxism (SB) and obstructive sleep apnea (OSA) are co-occurring conditions. The study aimed to evaluate the association of selected single-nucleotide polymorphisms (SNPs) occurring within genes serotonin dopamine pathways in SB OSA investigate relationship between them. group included 100 Caucasian patients. were diagnosed 74 28 patients, respectively. In addition, 125 unrelated healthy blood donors served as randomly controls enable comparison polymorphisms. following SNPs...
Micro- and nanoplastic particles, including common forms like polyethylene polystyrene, have been identified as relevant pollutants, potentially causing health problems in living organisms. The mechanisms at the cellular level largely remain to be elucidated. This study aims visualize nanoplastics bronchial smooth muscle (BSMC) small airway epithelial cells (SAEC), assess impact on mitochondrial metabolism. Healthy asthmatic human BSMC SAEC vitro cultures were stimulated with polystyrene...
Objective Rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic (PsA) belong to inflammatory rheumatic diseases, the group of conditions unknown etiology. However, a strong genetic component in their pathogenesis has been well established. A dysregulation cytokine networks plays an important role development arthritis. Interleukin 33 (IL-33) is recently identified member IL-1 family. To date, significance IL-33 poorly studied. This research aimed investigate potential gene...
Secretion of renin juxtaglomerular cells into bloodstream initiates activation an enzymatic-hormonal cascade known as the RAAS (renin - angiotensin aldosterone system). As a result, blood pressure is increased by means several interrelated mechanisms. Mechanism Zjednoczoaction this system has been for decades, but few previously unknown components were recently added, such ACE-2 and Ang(1-7), their role often seems to be opposite that conventional components. Local tissue systems also have...
Healthcare systems heavily rely on antibiotics to treat bacterial infections, but the widespread presence of multidrug-resistant bacteria puts this strategy in danger. Novel drugs capable overcoming current resistances are needed if our ability infections is be maintained. Boron clusters offer a valuable possibility create new class and expand chemical space beyond conventional carbon-based molecules. In work, we identified two promising structural patterns providing cobalta...
Multiple myeloma (MM) is a plasma-cell malignancy derived from an early precursor of the B-cell lineage characterised by bone-marrow infiltration, lytic bone lesions, and presence monoclonal protein in serum and/or urine. Interferon regulatory factor 4 (IRF4) critical transcriptional regulator development function that required during immune response for lymphocyte activation generation immunoglobulin-secreting plasma cells. Immunomodulatory drugs, derivatives thalidomide, are commonly used...
IL-17A and IL-17F together with their coreceptor (IL-17RA/RC) were reported to play a significant role in the pathogenesis of spondyloarthritis. The group axial spondyloarthritis comprises ankylosing spondylitis (AS), rheumatic disease characterized by chronic inflammation joints spine. This study is aimed at investigating IL-17A, IL-17F, IL-17RA, IL-17RC polymorphisms as potential biomarkers susceptibility, clinical parameters, anti-TNF treatment outcome cohort Polish patients. In total,...
Obstructive sleep apnea (OSA) is frequently associated with a chronic inflammatory state and cardiovascular/metabolic complications. The aim of this study was to evaluate the influence certain comorbidities on panel 45 chemokines cytokines in OSA patients special regard their possible association cardiovascular diseases.This cross-sectional performed 61 newly diagnosed patients. For measurement plasma concentration cytokines, magnetic bead-based multiplex assay for Luminex® platform used.In...
Abstract Inconsistency of the results regarding genetic variability within genes coding for receptor activator nuclear factor κB (RANK) and its ligand (RANKL) in rheumatoid arthritis (RA) prompted us to study RANK RANKL polymorphisms as potential biomarkers associated with disease predisposition response anti-TNF treatment a group Polish patients RA. This enrolled 318 RA 163 controls. (rs8086340, C > G; rs1805034, T) (rs7325635, G A; rs7988338 A) alleles were determined by real-time PCR...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak is a major challenge for clinicians. SARS-CoV-2 infection results in disease 2019 (COVID-19), and it best known its symptoms. It can also result several extrapulmonary manifestations such as neurological complications potentially experienced during the course of COVID-19. association dermatomyositis (DM) with COVID-19 pathogenesis has not been well-studied. This study aimed to present previously healthy 37-year-old...
Background/Aim: Although genetic factors are presumed to account only for a part of the inter-individual variation in lung cancer susceptibility, results conflicting and there no data available regarding Polish population. We, therefore, performed case-control study investigate association seven selected single nucleotide polymorphisms (SNPs), genes coding excision repair cross-complimentary group 1 (ERCC1: rs11615, rs3212986, rs2298881), nuclear factor ĸB (NFKB2: rs7897947, rs12769316),...
Introduction: Lung cancer belongs to the most common carcinoma worldwide and is leading cause of cancer-related death. Bone morphogenetic protein-4 (BMP-4) extracellular signaling molecule involved in many important processes, including cell proliferation mobility, apoptosis angiogenesis. Thrombospondin-1 (TSP-1) matrix proteins. It participates cell-to-cell cell-to-matrix interactions thus plays role tumor microenvironment for development metastasis formation. Aim: To investigate serum...
Healthcare systems heavily rely on antibiotics to treat bacterial infections but widespread of the multidrug-resistant bacteria puts this strategy in danger. Novel drugs capable overcoming current resistances are needed if our ability is be maintained. Boron clusters offer a valuable possibility create new class and expand antibiotic’s chemical space beyond conventional carbon-based molecules. In work, we identified two promising structural patterns providing cobalta...
Articular cartilage lesions negatively affect patients' well-being, causing severe pain and significantly limiting functioning. The purpose of this study was to evaluate the effectiveness a one-stage reconstruction, performed arthroscopically using hyaluronate-based scaffold. Pain reduction functional improvement were assessed. also evaluated if postoperative vitamin D supplementation rehabilitation protocol impact obtained outcomes. A group 29 patients included in retrospective study. All...
Rationale: The shape and membrane dynamics of individual red blood cells (RBCs) are known to play a significant role in their functionality. morphodynamics RBCs optimizes flow properties vessels capillaries, which is important for the balance optimal distribution nutrients tissues. It also crucial pathological contexts because changes can influence vascular microvascular hemodynamics. dysregulate function through modulation oxygen delivery scavenging generation nitric oxide. Therefore, ideal...