Abstract Background Schizophrenia is a disorder characterized by positive and negative symptoms impairments in cognitive functions (1). Current medications treatment are mostly effective on the of disease; but has limited effectiveness Two main hypotheses for schizophrenia pathophysiology increased dopaminergic transmission decreased glutamatergic brain (2). However, can nor fully explained these Several other mechanisms also targeted to explore such as alteration gamma-amino butyric acid...

Pregabalin (PGB) is a compound used in the treatment of epilepsy, anxiety, and neuropathic pain. Experimental data also indicate that PGB can reduce inflammatory We aimed to investigate anti-inflammatory effects on carrageenan (CAR)-induced paw edema its tumor necrosis factor-α (TNF-α) interleukine-1β (IL-1β) acting as acute phase cytokines inflammation, cytokine IL-10, rats.Single doses 30, 50, 100 mg/kg indomethacin (INDO) 5 groups saline control group were injected once intraperitoneally...

In this study, the aim is to observe changes induced by dehydroepiandrosterone (DHEA) and resveratrol (RES) in diminished ovarian follicles that was 4-vinylcyclohexenediepoxide (VCD).Twenty four Wistar albino female rats were divided into 3 groups: control, DHEA RES. Unilateral oophorectomy performed control group remove right ovary of 4 left rats. After administration 160 mg/kg VCD, remaining ovaries removed. Following same VCD treatment, RES groups, 60 20 given for 45 days respectively...

Gabapentin, a third-generation antiepileptic drug, is structural analogue of γ-aminobutyric acid, which an important mediator central nervous system. There clinical data indicating its effectiveness in the treatment psychiatric illnesses such as bipolar disorder and anxiety disorders.We aimed to investigate antidepressant anxiolytic-like effects mechanisms gabapentin rats.Female Spraque-Dawley rats weighing 250±20 g were used. A total 13 groups formed, each containing 8 rats: (5, 10, 20, 40...

Cisplatin is a widely used antineoplastic agent in the treatment of various cancers. Peripheral neuropathy well-known side effect cisplatin and has potential to result limiting and/or reducing dose, decreasing quality life. Thus, effective treatments are needed. Agmatine an endogenous neuromodulator that been shown exert antiallodynic effects animal studies. The first aim this study was investigate vitro agmatine on cisplatin-induced neurotoxicity. Primary cultures dorsal root ganglia (DRG)...

BACKGROUND: Galangin, a fl avonoid compound with acetylcholinesterase inhibitory activity, may improve cognitive functions by enhancing cholinergic transmission.OBJECTIVES: We aimed to investigate the effects of galangin on spatial memory impairment in rats.METHODS: The (50 and 100 mg/kg) reference anti-dementia drug donepezil (1mg/ kg) administrations were examined induced muscarinic receptor antagonist scopolamine or nicotinic mecamylamine Morris water maze (MWM) test.Hippocampal...

Background: Calcium homeostasis is considered to be important in antineoplastic as well neurotoxic adverse effects of cisplatin.Aims: This study aimed investigate the role Ca 2+ cisplatin neurotoxicity cultured rat dorsal root ganglia (DRG) cells.Study Design: Cell culture study.Methods: DRG cells prepared from 1-day old Sprague-Dawley rats were used determine (10-600 μM) neurotoxicity.The incubated with plus nimodipine (1-3 μM), dizocilpine (MK-801) or thapsigargin (100-300 nM).Toxicity...

Acetylcholinesterase inhibitors are the focus of interest in management schizophrenia. We aimed to investigate effects acute galangin administration, a flavonoid compound with acetylcholinesterase inhibiting activity, on schizophrenia-associated cognitive deficits rats and schizophrenia models mice.Apomorphine-induced prepulse inhibition (PPI) disruption for functions, nicotinic, muscarinic, serotonergic mechanism involvement, brain acetylcholine levels were investigated Wistar rats....

Background: Chemerin is a novel chemoattractant adipokine expressed in cardiovascular system, and its receptor has been detected the epicardial adipose tissue. Aims:To determine effects of chemerin on cardiac parameters gene expressions isolated perfused rat heart.Study Design: Animal experiment. Methods:The hearts were retrogradely with Langendorff technique to measure parameters.The experimental groups acutely treated 10, 100, 1000 nM doses chemerin.Another group was given 10 μM L-nitric...

Intracellular calcium contributes to the development of affective disorders. Also, channel inhibitors influence activity many neurotransmitters and exert antidepressant anxiolytic properties.The aim this study was examine effects sertraline on anxiety depressive behaviors role nimodipine, a antagonist, these effects.Forced swimming elevated plus maze tests were used assess depression respectively in rats. Sertraline (10 mg/kg) administered repeatedly for 7 days both alone combination with...

Objective: It was suggested that prostaglandins which are synthesized by cyclooxygenase (COX) enzymes contribute to the actions of angiotensin-converting enzyme (ACE) inhibition and angiotensin AT1 receptor antagonism there is an interaction between ACE signaling pathway COX enzymes.We aim investigate role in effects losartan, II (Ang II) antagonist or lisinopril, inhibitor, on contractions rat thoracic aorta isolated tissue bath.Materials Methods: Responses losartan (10 -6 , 10 -5 -4 M),...

Background/aim: Cisplatin (CIS) is an effective antineoplastic agent used in the treatment of several cancer types. Peripheral neuropathy a major dose-limiting side-effect CIS therapy. Cannabinoids may alleviate this painful side effect. This study investigated analgesic effects anandamide (AN) on CIS-induced peripheral neuropathy, vitro AN neurotoxicity, and contribution nitric oxide (NO) Materials methods: experimental animal study. Primary dorsal root ganglion (DRG) cultures were prepared...

Safe and effective drugs are still lacking for many pain therapies. In recent years, growing interest has been devoted thus on herbal as an option to identify new killers. Based this, extensive researches carried out Verbascum L. genus due its therapeutic potency inflammation therapy. this study, among species, the antinociceptive effect of exuberans Hub.-Mor., contributions nitrergic, serotonergic, or opioidergic pathways well antiinflammatory acitivity were investigated.Tail clip, tail...

We aimed to investigate the effects and mechanisms of action p-nonylphenol(p-NP) on uterine contractility in rats. The tissues female Sprague Dawley rats diestrus were bathed isolated organ bath. vehicle alone (0.1% ethanol), positive control 17-β-E₂ (10⁻⁵ M) p-NP (10⁻⁹ M, 10⁻⁸ 10⁻⁷ 10⁻⁶ spontaneous KCl-induced studied. Also, combination with actinomycin D (gene transcription inhibitor), cycloheximide (10⁻⁴ (protein...

In this study, novel condensed 1,4-dihydropyridines bearing cyclopentanone (1–21) or tetrahydrothiophene-1,1-dioxide ring (22–42) with various ester substituents were synthesized via a modified Hantzsch reaction and their calcium channel modulator activities investigated on isolated rat ileum thoracic aorta. The introduction of fused to the 1,4-dihydropyridine nucleus methyl, ethyl allyl moieties group led more active modulators.

Pregabalin, a drug used in epilepsy, anxiety, neuropathic pain is reported to have analgesic effects inflammatory pain. We aimed investigate whether pregabalin gastric side and compare with non steroidal antiinflammatory (NSAID) rats. The of on antioxidant levels, which are suggested protect against mucosal damage were also studied. Pregabalin 30, 50, 100 mg/kg, indomethacin 5 mg/kg (reference-NSAID), saline (control group) administered orally for 10 days. At the end day treatment, rats...

Besides its approval as an adjunctive anticonvulsant, gabapentin was reported to be effective in neuropathic and inflammatory pain.Antihyperalgesic effect of may related possible antiinflammatory activity.We aimed examine the chronic administration on response rats.Experiments were performed with permission Local Ethical Committee Eskisehir Osmangazi University for Animal Experimentation (03.03.2011/192).Male Spraque-Dawley rats (200-250g) randomly divided into control (saline), 10, 30,...

Nicotinic acetylcholine (nACh) receptors evoke convulsive seizures both in nicotine intoxication and human epileptic disorders (e.g., autosomal dominant nocturnal frontal lobe epilepsy [ADNFLE]).Here, we performed behavioral immunohistochemical studies to elucidate the mechanisms of nicotineinduced seizures.Nicotine at high doses (4 mg/kg, i.p.) evoked seizures, which was antagonized by non-selective (mecamylamine) α7-selective (methyllycaconitine) nACh receptor antagonists.Nicotine-induced...

Objectives: Des-Arg9-bradykinin and bradykinin-potentiating peptide C (BPPC) may contribute to the regulation of cardiovascular function. Therefore, we studied effects these peptides on coronary perfusion pressure (CPP), heart rate, left ventricular developed (LVDP) maximum rate increase (+dP/dtmax). Methods: The isolated rat hearts were perfused with modified Krebs-Henseleit solution. Results: Infusion 10, 100 1000 nM decreased CPP (−13.6, −14.8 −19.0%), LVDP (−16.5, −21.0 −30.7%) +dP/dtmax...

Objective: The aim of this study was to examine the effects chronic administration ziprasidone, an atypical antipsychotic drug, on experimental models psychosis and role nimodipine, a dihydropyridine calcium channel blocker, these in mice.Methods: Experimental were studied mice. Amphetamine-induced hyperlocomotion, haloperidol- induced catalepsy, apomorphine-induced climbing tests used as psychosis. One 10mg/kg doses ziprasidone given mice i.p. for 10 days. Nimodipine single injection at...

Objective: Agmatine is an endogenous cationic amin and have been reported several neurotherapeutic effects through α2-adrenoceptors, imidazoline binding sites, inhibition of NMDA receptors nitric oxide (NO) synthase. NO was to act as a neuromodulator neurotransmitter in central nervous system has proconvulsant/anticonvulsant activities convulsion models. We aimed compare the anticonvulsant agmatine, sodium valproate, gabapentin phenytoin, investigate role drugs. Material Methods: Epilepsy...