Abstract Objectives This study investigated the effects of H 2 S donor sodium hydrosulfide (NaHS) on demyelination and behavioral deficits in a cuprizone (CPZ)-induced experimental rat model MS. Methods The rats were fed chow pellets supplemented with 1% CPZ for 5 weeks, NaHS (50 100 μmol/kg) was administered during last weeks. For assessment, grip strength, passive avoidance, rota rod elevated plus maze tests performed. Nuclear factor kappa-B (NF-κB) interleukin-1 beta (IL-1β) measured to...

Introduction: The implantation of mesenchymal stem cells (MSCs) has been shown to exert benefits for the survival zone-of-stasis. However, clinical experience indicates importance selecting right source and type cells. Therefore, we planned current study perform a quantitative comparison MSCs isolated from three different sources provide information useful in selection optimal see whether critical mechanisms are conserved between populations. Methods: protective effects derived bone marrow,...

Introduction Burns are dynamic wounds that may present a progressive expansion of necrosis into the initially viable zone stasis. Therefore, salvage this is major subject focus in burn research. The beneficial effects mesenchymal stem cells (MSCs) on survival stasis have been previously documented. However, many gaps still exist our knowledge regarding underlying protective mechanisms. Hence, study was designed to evaluate pathophysiological basis MSCs prevention wound progression. Methods...

The objective of this study was to determine whether there are changes in primary, primordial, and growing follicles after dehydroepiandrosterone (DHEA) administration rats that have diminished ovarian reserve (DOR) due 4-vinylcyclohexene diepoxide (VCD) application, examine the mechanism probable effect DHEA on folliculogenesis. Two groups Wistar were used. In Group A unilateral oophorectomy (eight rats) carried out day-0. remaining ovary removed by relaparotomy VCD (160 mg/kg,...

Cyclophosphamide (CP) is a drug used for treatment of many malignant diseases. However, it can cause serious side effects such as hemorrhagic cystitis and male infertility. Hydrogen sulfide (H2S) gaseous mediator suggested to have antioxidant, antiinflammatory, antiapoptotic effects. In this study, dose-dependent H2S donor sodium hydrosulfide (NaHS) on cyclophosphamide-induced testicular dysfunction were investigated in rats.Rats divided into 5 groups (n = 8): control, CP, NaHS25 μmol/kg,...

Abstract Aim To investigate whether recombinant klotho given concomitantly with cisplatin is effective in preventing cisplatin‐induced ovarian damage. Methods Thirty‐two adult female mice were divided into four groups. Saline was to the first group, second mouse third and + fourth group. The removed tissues examined groups compared histologically immunohistochemical examination for antimullerian hormone (AMH), superoxide dismutase (SOD) catalase expression done. Glutathione peroxidase (GPx)...

Successful limb replantation must be based not only on the viability of amputated part but also satisfactory long-term functional recovery. Once vascular, skeletal, and soft-tissue problems have been taken care of, nerve recovery becomes ultimate limiting factor. Unfortunately, regeneration after is impaired by several consequences. The authors tested hypothesis that bone marrow mesenchymal stem cells could improve outcomes in an experimental model replantation.Twenty rats underwent total...

Background: Cyclophosphamide (CP) is a well-known alkylating anticancer agent used in the treatment of various malignant and non-malignant tumors. CP may also cause variety adverse effects, including reproductive toxicity. Amifostine known as cytoprotective drug having antioxidant properties. Objective: To evaluate possible beneficial effects amifostine on testicular toxicity induced by rats. Materials Methods: A total 35 Sprague-Dawley rats were this experimental study. The group animals...

In this study, the aim is to observe changes induced by dehydroepiandrosterone (DHEA) and resveratrol (RES) in diminished ovarian follicles that was 4-vinylcyclohexenediepoxide (VCD).Twenty four Wistar albino female rats were divided into 3 groups: control, DHEA RES. Unilateral oophorectomy performed control group remove right ovary of 4 left rats. After administration 160 mg/kg VCD, remaining ovaries removed. Following same VCD treatment, RES groups, 60 20 given for 45 days respectively...

The protective and/or therapeutic potential of tadalafil (TDL) on cyclophosphamide (CP)-induced hemorrhagic cystitis (HC) and testicular dysfunction in rats was evaluated.The animals except from the control group were divided into four groups treated with saline, or 1, 5 10 mg/kg TDL orally (CP, TDL1, TDL5 TDL10 groups, respectively) before after CP injection. Body organ weights, sperm count, cGMP, nitric oxide (NO), IL-6 IL-10 levels serum bladder tissue, testosterone (T), LH FSH...

Cyclophosphamide is a commonly used anticancer and immunosuppressive agent; however, hepatotoxicity one of its severe toxicities. Hydrogen sulfide gaseous signaling molecule that plays crucial regulatory roles in various physiological functions. This study aimed to evaluate the hepatoprotective effect hydrogen against cyclo phosp hamid e-ind uced hepatic damage rats.Hepatotoxicity was induced by single intraperitoneal administration cyclophosphamide (200 mg/kg). Sprague-Dawley rats were...

Objective:The aim of the present study was to investigate possible beneficial effects resveratrol in mice subjected vinyl cyclohexene dieposide (VCD) -induced testicular toxicity. Material and methods:A total thirty-six Swiss albino male aged 28-days were used study.The composed two stages where which received or did not receive VCD (320 mg/kg/day) administered resveratrol.The animals assigned into control resveratrol-treated groups first stage VCD-and VCD+resveratrol-treated second stage.At...

Alkylphenols have xenoestrogenic activity, which mimic the action of physiological estrogens and these mimicking activities are mainly mediated by nongenomic pathway. Nongenomic pathway plays a pivotal role in breast, endometrial ovarian cancers’ growth development. In this study, various alkylphenol derivatives were prepared screened for their anti-uterotrophic uterotrophic activity. Among compounds, 2-hydroxy-5-nonanoylbenzamide (compound 1b) showed 93.99% inhibitory activity test...

Journal Article The Notch Signaling System Is Involved in the Regulation of Reparative Angiogenesis Zone Stasis Get access Ozan Luay Abbas, MD, MD *Department Plastic, Reconstructive and Aesthetic Surgery, Ahi Evran University, Kirşehir, Turkey 1Address correspondence to Department Faculty Medicine, 40100 Turkey. E-mail: ozanluay@hotmail.com. Search for other works by this author on: Oxford Academic Google Scholar Orhan Özatik, †Department Histology Embryology, Yunus Kasim Terzi, PhD, PhD...

Intracellular calcium contributes to the development of affective disorders. Also, channel inhibitors influence activity many neurotransmitters and exert antidepressant anxiolytic properties.The aim this study was examine effects sertraline on anxiety depressive behaviors role nimodipine, a antagonist, these effects.Forced swimming elevated plus maze tests were used assess depression respectively in rats. Sertraline (10 mg/kg) administered repeatedly for 7 days both alone combination with...

Objectives: This study investigates the estrogen-like effects of resveratrol (RES) in female rats. Materials and Methods:In this two-step on estrogenlike activity RES, immature rats (21 days old) were used first step pubertal (28 with primary ovarian failure (POF) induced by 4-vinylcyclohexene diepoxide (VCD) second step.Possible agonistic and/or antagonistic RES investigated using several parameters including ratios uterine/body weights (UBW), uterine dry/wet (UDWW) body weight increase...

To examine the effects of cisplatin on uterine histology and implantation molecules possible protective role recombinant Klotho administration receptivity in mice exposed to cisplatin.This study was conducted using thirty-two adult female assigned four groups with 8 each group. Saline given 1st group, 2nd mouse 3rd group plus 4th Uterine tissues were examined for damage histologically immunobiologically markers HOXA13 alphaVBeta3 integrin.Apoptosis, degeneration, decrease thickness absence...

Objective: It was suggested that prostaglandins which are synthesized by cyclooxygenase (COX) enzymes contribute to the actions of angiotensin-converting enzyme (ACE) inhibition and angiotensin AT1 receptor antagonism there is an interaction between ACE signaling pathway COX enzymes.We aim investigate role in effects losartan, II (Ang II) antagonist or lisinopril, inhibitor, on contractions rat thoracic aorta isolated tissue bath.Materials Methods: Responses losartan (10 -6 , 10 -5 -4 M),...