A5010530875- Cytomegalovirus and herpesvirus research
- HIV Research and Treatment
- Fetal and Pediatric Neurological Disorders
- Herpesvirus Infections and Treatments
- Respiratory viral infections research
- Neonatal and Maternal Infections
- Toxoplasma gondii Research Studies
- Hepatitis B Virus Studies
- Parvovirus B19 Infection Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Down syndrome and intellectual disability research
- Long-Term Effects of COVID-19
- Prenatal Screening and Diagnostics
- RNA regulation and disease
- Legionella and Acanthamoeba research
- Influenza Virus Research Studies
Prince of Wales Hospital
2017-2024
UNSW Sydney
2018-2024
New South Wales Department of Health
2020-2024
Human cytomegalovirus (CMV) infection is the leading non-genetic aetiology of congenital malformation in developed countries, causing significant fetal neurological injury. This study investigated potential CMV pathogenetic mechanisms neural using vitro human cerebral organoids. Cerebral organoids were permissive to replication, and dysregulated cellular pluripotency differentiation pathways. Aberrant expression dual-specificity tyrosine phosphorylation-regulated kinases (DYRK), sonic...
Human cytomegalovirus (HCMV) infection is shaped by a tightly regulated interplay between viral and cellular proteins. Distinct kinase activities, such as the cyclin-dependent ortholog (vCDK) pUL97 CDK7 are both crucial for efficient replication. Previously, we reported that kinases, vCDK/pUL97 CDK7, interact with cyclin H, thereby achieving an enhanced level of activity overall functionality in Here provide variety novel results, generated on methodologically extended basis, present concept...
For 27 years, national prospective data on selected rare childhood diseases have been collected monthly by the Australian Paediatric Surveillance Unit (APSU) from paediatricians and other clinical specialists who report cases in children aged up to 16 years. We here annual results of APSU surveillance 2020 for ten communicable complications diseases, namely: acute flaccid paralysis (AFP); congenital cytomegalovirus (CMV) infection; neonatal herpes simplex virus (HSV) perinatal exposure human...
Human cytomegalovirus (CMV) infection is the leading non-genetic cause of congenital malformation in developed countries, causing significant fetal injury, and some cases death. The pathogenetic mechanisms through which this host-specific virus infects then damages both placenta brain are currently ill-defined. We investigated CMV modulation key signaling pathway proteins for these organs including dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) Sonic Hedgehog (SHH) using...